Biomaterial for soft tissue healing
Total Trials
188
As Lead Sponsor
143
As Collaborator
45
Total Enrollment
35,480
NCT00517153
Miglustat in Niemann-Pick Type C Disease
Phase: Phase 2
Role: Lead Sponsor
Start: Jan 31, 2002
Completion: Jan 31, 2008
NCT00070590
Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma
Phase: Phase 2/3
Start: Jul 31, 2003
Completion: Sep 30, 2005
NCT00082186
The Effect of Tracleer® on Male Fertility
Phase: Phase 4
Completion: Nov 30, 2007
NCT00071461
Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis
Start: Aug 31, 2003
Completion: May 31, 2010
NCT00317486
Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology
Start: Sep 30, 2003
Completion: Apr 30, 2005
NCT00077584
Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma
Phase: Phase 3
Start: Oct 31, 2003
Completion: May 31, 2005
NCT00367770
BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Physiology
Start: Jan 31, 2004
Completion: Dec 31, 2005
NCT00091715
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
Start: Apr 30, 2004
Completion: Feb 28, 2011
NCT00086463
Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH)
Start: Jun 30, 2004
Completion: Jan 31, 2006
NCT00319696
Bosentan in Digital Ulcers
Start: Jul 8, 2004
Completion: Jan 22, 2009
NCT00319033
Open-label Study With Bosentan in Interstitial Lung Disease
Start: Jul 31, 2004
Completion: Feb 28, 2006
NCT00418847
Pharmacokinetics and Tolerability of Zavesca® (Miglustat) In Patients With Juvenile GM2 Gangliosidosis
Role: Collaborator
Completion: Apr 30, 2009
NCT00672022
Pharmacokinetics, Safety and Tolerability of Zavesca (Miglustat) in Patients With Infantile Onset Gangliosidosis: Single and Steady State Oral Doses
Completion: Aug 31, 2007
NCT00266162
Bosentan in Treatment of Pulmonary Arterial Hypertension
Start: Aug 31, 2004
Completion: Feb 29, 2008
NCT00109681
Inhaled Iloprost in Adults With Abnormal Pulmonary Pressure and Associated With Idiopathic Pulmonary Fibrosis
Start: Apr 30, 2005
Completion: Oct 31, 2006
NCT00319267
Bosentan in Children With Pulmonary Arterial Hypertension
Start: May 31, 2005
Completion: Feb 28, 2007
NCT00319020
Bosentan in Children With Pulmonary Arterial Hypertension Extension Study
Start: Aug 23, 2005
Completion: Oct 28, 2011
NCT01009177
Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC)
Start: Sep 30, 2005
NCT00313222
Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension
Start: Oct 31, 2005
Completion: Mar 31, 2007
NCT00319111
Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Start: Jan 31, 2006
NCT00302211
"The VISION Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension"
Start: Feb 1, 2006
Completion: Jul 1, 2008
NCT00319046
Clinical Study to Evaluate the Long Term Efficacy, Safety and Tolerability of Miglustat in Patients With Stable Type 1 Gaucher Disease
Completion: Jul 1, 2010
NCT00310830
Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH)
Start: Mar 31, 2006
NCT00360087
A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study
Completion: Dec 31, 2007
NCT00370214
REVEAL Registry™: Registry to Evaluate Early And Long-term PAH Disease Management
Phase: N/A
Completion: Dec 31, 2012
NCT00313196
Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH)
Start: Apr 30, 2006
NCT00303459
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)
Start: May 31, 2006
Completion: Dec 31, 2013
NCT00595049
Pulmonary Artery Remodelling With Bosentan
Completion: Jun 30, 2010
NCT00453414
Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension
Start: Jul 31, 2006
NCT00432978
Effect of Bosentan on Exercise Capacity at High Altitude
Phase: Phase 1
NCT00467896
"The Power 15 Study: Safety Study of Inhalation of Ventavis With the Power Disc-15 Setting"
Start: Sep 30, 2006
Completion: Jun 30, 2011
NCT00377455
Placebo Controlled Trial of Bosentan in Scleroderma Patients
Completion: Mar 31, 2010
NCT00391443
BUILD 3: Bosentan Use in Interstitial Lung Disease
Start: Feb 28, 2007
Completion: Jul 31, 2010
NCT00433329
Combination Therapy in Pulmonary Arterial Hypertension
Start: Mar 31, 2007
Completion: Aug 31, 2010
NCT00543413
A Study to Determine the Effectiveness and Tolerability of MK8141 in Patients With High Blood Pressure (MK-8141-006)
Start: Oct 31, 2007
Completion: Jun 30, 2008
NCT00625469
Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan
Completion: Dec 31, 2009
NCT00537602
Miglustat / OGT 918 in the Treatment of Cystic Fibrosis
Start: Nov 30, 2007
Completion: Mar 31, 2008
NCT01357109
Effect of Bosentan on Endothelial Function in Patients With Type 2 Diabetes
Completion: Jan 31, 2011
NCT00777985
Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea
Start: Dec 31, 2007
Completion: Jan 31, 2012
NCT00909337
Early Therapy of Pulmonary Arterial Hypertension
Start: Jan 31, 2008
NCT00631475
Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443
Start: Apr 30, 2008
NCT00993408
Study of ACT-293987 (NS-304) in Pulmonary Arterial Hypertension (PAH)
Completion: Jun 30, 2009
NCT00581607
Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary Hypertension
NCT00637065
Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study
NCT00660179
Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
Start: May 31, 2008
Completion: Apr 30, 2012
NCT00709956
Iloprost Power 15 in Pulmonary Arterial Hypertension
Start: Jul 31, 2008
Completion: Aug 31, 2009
NCT00723554
Iloprost Power Disc-15 in Pulmonary Arterial Hypertension
Completion: Apr 30, 2011
NCT00708565
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
Completion: Oct 31, 2008
NCT00742092
Miglustat in Cystic Fibrosis
Start: Aug 31, 2008
Completion: Dec 31, 2008
NCT00709098
Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial Hypertension
Start: Sep 30, 2008
NCT00667823
Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension
Start: Oct 17, 2008
Completion: Dec 7, 2020
NCT00706082
Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc)
Start: Oct 31, 2008
Completion: Mar 31, 2012
NCT00852670
ACT-128800 in Psoriasis
Completion: Sep 30, 2009
NCT00815347
Bosentan for Poorly Controlled Asthma
Start: Dec 31, 2008
Completion: Sep 30, 2010
NCT00638131
Bosentan Use in Patients With Diabetic Nephropathy
Start: Jan 31, 2009
NCT02223832
Study to Evaluate the Pharmacokinetics, Tolerability, and Safety of ACT-128800 in Japanese and Caucasian Healthy Male and Female Subjects
Start: Feb 28, 2009
NCT00902603
Ventavis® Registry Protocol
Start: Mar 31, 2009
Completion: Feb 28, 2014
NCT02126956
Mass Balance, Pharmacokinetics, and Metabolism of 14C-labeled ACT-128800 Administered to Healthy Male Subjects
NCT00864201
A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
Start: Apr 30, 2009
Completion: Apr 30, 2010
NCT00903331
Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study
Start: May 31, 2009
Completion: Aug 31, 2011
NCT00981591
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
Phase: Phase 1/2
Start: Sep 30, 2009
Completion: Mar 31, 2013
NCT01006265
Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of ACT-128800 in Patients With Relapsing-remitting Multiple Sclerosis
Start: Oct 1, 2009
Completion: Jul 1, 2011
NCT01106014
Selexipag (ACT-293987) in Pulmonary Arterial Hypertension
Start: Dec 1, 2009
Completion: Oct 1, 2014
NCT01247116
First-line Bosentan and Sildenafil Combination Therapy for Pulmonary Arterial Hypertension
Start: Dec 31, 2009
Completion: Dec 31, 2015
NCT01105091
Epoprostenol for Injection in Pulmonary Arterial Hypertension
Start: Mar 31, 2010
Completion: Jul 31, 2011
NCT02029482
Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-128800 in Healthy Subjects
Start: Apr 30, 2010
NCT01779609
ET-blockade and Exercise-induced Vascular Adaptations in T2DM
NCT01093326
Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis
Start: May 12, 2010
Completion: Sep 6, 2023
NCT01105117
Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401
Start: May 31, 2010
Completion: Dec 31, 2011
NCT00989911
Endothelin Blockade in Patients With Single Ventricle Physiology
NCT01112306
ACT-293987 in Pulmonary Arterial Hypertension
Start: Jul 7, 2010
Completion: Aug 26, 2021
NCT01209533
Inhaled Iloprost in Mild Asthma
Phase: Early Phase 1
Start: Sep 30, 2010
NCT01208090
ACT-128800 in Patients With Moderate to Severe Chronic Plaque Psoriasis
Start: Oct 31, 2010
Completion: Nov 30, 2012
NCT01317134
Endothelial Function in Patients With Pulmonary Arterial Hypertension
Completion: Jul 31, 2016
NCT01241383
Effect of Bosentan in Scleroderma Renal Crisis
Start: Dec 31, 2010
Completion: Jun 30, 2016
NCT01222702
Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD)
Start: Jan 25, 2011
Completion: Nov 12, 2012
NCT01377090
Digital Ulceration
Start: Jan 31, 2011
Completion: Aug 31, 2012
NCT01292551
Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.
Start: Feb 28, 2011
NCT01223352
Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension
Start: Mar 8, 2011
Completion: Aug 19, 2013
NCT01338415
FUTURE 3 Study Extension
Completion: May 29, 2020
NCT01395732
Bosentan in Systemic Sclerosis
Start: Mar 31, 2011
NCT01431716
Epoprostenol for Injection (EFI/ACT-385781A) - Pulmonary Arterial Hypertension
Completion: Jul 31, 2012
NCT01274481
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
NCT01389206
Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program
Start: Jun 1, 2011
Completion: Apr 10, 2018
NCT01470144
Epoprostenol for Injection in Patients With Pulmonary Arterial Hypertension
Completion: Jul 1, 2015
NCT01319045
Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart Disease
Start: Jun 30, 2011
Completion: May 31, 2013
NCT01346930
Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis
Start: Jul 31, 2011
Completion: Aug 31, 2016
NCT01378845
Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on Hands
Completion: Sep 30, 2015
NCT02050802
Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects
Start: Aug 31, 2011
Completion: Nov 30, 2011
NCT02136888
Study of the Electrocardiographic Effects of Ponesimod in Healthy Male and Female Subjects
Completion: Feb 29, 2012
NCT01659411
Adult Congenital Heart Disease Registry (QuERI)
Start: Dec 1, 2011
Completion: May 16, 2018
NCT01389856
Persistent Pulmonary Hypertension of the Newborn
Start: Dec 31, 2011
Completion: Jan 31, 2014
NCT01474109
Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients
Completion: Nov 30, 2013
NCT01474122
NCT01499251
Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Patients With Recurrent Glioblastoma
Start: Jan 31, 2012
Completion: Apr 30, 2016
NCT01437878
Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Disease (COPD)
Start: Mar 31, 2012
NCT01508780
Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral Bosentan
Start: May 31, 2012
NCT02206204
Study of Selexipag and Its Metabolite ACT-333679 on Cardiac Repolarization in Healthy Male and Female Subjects
Start: Jun 30, 2012
NCT01623492
Eisenmenger Quality Enhancement Research Initiative
Start: Jul 1, 2012
Completion: Apr 17, 2018
NCT02053181
Study to Investigate the Pharmacokinetics and Safety of Cadazolid in Patients With Clostridium Difficile Infection
Start: Aug 31, 2012
Completion: Sep 30, 2012
NCT02206295
Study in Healthy Male Subjects to Demonstrate Bioequivalence of 1600 μg Selexipag Administered as Eight Tablets of 200 μg or as Single Tablet of 1600 μg
Start: Sep 30, 2012
NCT01976533
Eisenmenger Syndrome in the Nordic Countries
Start: Oct 31, 2012
Completion: Oct 31, 2016
NCT01822028
Two Period / Two Treatment Cross-over to Assess the Effect of Florastor® on Gastrointestinal Tolerability, Safety, and PK in Healthy Subjects Receiving Zavesca®
Start: Mar 31, 2013
Completion: Aug 31, 2013
NCT01841762
Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument
Start: Apr 1, 2013
Completion: Nov 1, 2015
NCT01743001
Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome
Start: May 21, 2013
Completion: Dec 1, 2016
NCT01847014
Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument
Start: Sep 1, 2013
Completion: Nov 30, 2017
NCT01739400
Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome
Start: Sep 10, 2013
Completion: Jan 12, 2018
NCT01983683
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea
Start: Dec 12, 2013
Completion: May 2, 2017
NCT02002351
Prospective Study on Rehabilitation Patients With Pulmonary Hypertension and Other Pulmonary Diseases
Start: Dec 31, 2013
Completion: Mar 31, 2016
NCT02081690
A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain
Start: Mar 1, 2014
NCT01987895
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea
Start: Mar 27, 2014
Completion: Mar 24, 2017
NCT02126943
OPsumit USers Registry
Start: Apr 30, 2014
Completion: Apr 24, 2020
NCT02570737
Latin American Pulmonary Hypertension Registry
Completion: Apr 30, 2019
NCT02112487
Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH
Start: Jun 23, 2014
Completion: Sep 19, 2018
NCT02070991
Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction
Start: Jul 1, 2014
NCT02021292
Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Start: Aug 20, 2014
Completion: Sep 28, 2016
NCT02068235
Study to Investigate the Absolute Bioavailability of a Single Oral Dose of Ponesimod in Healthy Male Subjects
Start: Aug 31, 2014
Completion: Nov 30, 2014
NCT02260557
Effects of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis
Start: Oct 31, 2014
Completion: Jun 30, 2015
NCT02254954
Clinical Study on Macitentan, RT and TMZ Concurrent Therapy Followed by Maintenance Macitentan and TMZ in Newly Diagnosed Glioblastoma
Start: Jan 8, 2015
Completion: Sep 29, 2016
NCT02309463
Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension
Start: Jan 31, 2015
Completion: Feb 28, 2017
NCT02882425
Absolute Bioavailability of a Single Oral Dose of Selexipag in Healthy Subjects
Completion: Apr 30, 2015
NCT02060721
Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Start: Feb 3, 2015
Completion: Mar 21, 2022
NCT02325362
Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del Mutation
Start: Mar 17, 2015
Completion: Apr 3, 2017
NCT02310672
REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension
Start: Jun 1, 2015
Completion: Sep 10, 2019
NCT02425644
Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
Start: Jun 4, 2015
Completion: May 16, 2019
NCT02382016
PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial
Start: Jun 23, 2015
Completion: Oct 31, 2018
NCT02480335
The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis
Start: Jun 26, 2015
Completion: Jul 30, 2018
NCT02520934
Miglustat on Gaucher Disease Type IIIB
Start: Jul 31, 2015
Completion: Dec 31, 2019
NCT02651272
Macitentan in Pulmonary Hypertension of Sickle Cell Disease
Completion: Dec 18, 2019
NCT02476864
Comparison of the Pharmacokinetic Properties of Two Tablet Formulations of Macitentan in Healthy Adults
Start: Aug 31, 2015
NCT02968901
Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA)
Start: Sep 1, 2015
Completion: Sep 10, 2018
NCT02471183
Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial Hypertension
Start: Oct 12, 2015
Completion: Dec 5, 2016
NCT02554903
Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation
Start: Mar 28, 2016
Completion: Mar 13, 2020
NCT02558231
The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension
Start: May 1, 2016
Completion: Apr 20, 2020
NCT02745860
Comparison of Two Dose Strengths of Selexipag in Healthy Adults
Start: Jun 30, 2016
NCT02770222
A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects
NCT02791815
Potential Pharmacokinetic Interaction Between Selexipag and Midazolam in Healthy Male Subjects
Start: Jul 31, 2016
Completion: Sep 30, 2016
NCT02461134
Clinical Study to Investigate the Biological Activity, Safety, Tolerability, and Pharmacokinetics of Ponesimod in Subjects With Symptomatic Chronic GVHD
Start: Sep 29, 2016
Completion: Mar 3, 2017
NCT02881749
Low Dose Total Skin Electron Beam Treatment (TSEBT) Followed by Maintenance Valchlor for Patients With Mycosis Fungoides
Start: Sep 30, 2016
Completion: Not specified
NCT03278002
A Registry for Patients Taking Uptravi
Start: Nov 1, 2016
Completion: Sep 21, 2021
NCT03078244
Protocol for a Multicentre Survey of Patients With Treatment Resistant Hypertension
Start: Nov 30, 2016
Completion: Aug 31, 2017
NCT02907177
Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®)
Start: Mar 30, 2017
Completion: Mar 26, 2020
NCT03105479
Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD)
Start: Apr 14, 2017
NCT05610631
Pulmonary Hypertension Registry Switzerland
Start: Jun 1, 2017
Completion: Dec 31, 2027
NCT03232073
Long-term Extension to Study AC-058B301 to Investigate Safety, Tolerability and Disease Control of Ponesimod 20 mg in Patients With Relapsing Multiple Sclerosis
Start: Jul 5, 2017
Completion: Jan 16, 2024
NCT03153111
A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Start: Jul 11, 2017
Completion: Mar 12, 2021
NCT03044314
Outpatient Vasodilator Assessment Using Iloprost in Pulmonary Hypertension
Start: Jul 21, 2017
Completion: May 19, 2020
NCT03197688
Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States
Start: Aug 3, 2017
Completion: Sep 6, 2018
NCT03215966
A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administration of the Reference Tablets of Macitentan and Tadalafil in Healthy Subjects
Start: Aug 7, 2017
Completion: Sep 24, 2017
NCT03153137
Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects
Start: Aug 14, 2017
Completion: Jul 26, 2021
NCT02932410
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)
Start: Oct 24, 2017
Completion: Nov 30, 2025
NCT03359291
Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of Healthy Male Subjects
Start: Nov 3, 2017
Completion: Dec 4, 2017
NCT03078907
Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.
Start: Nov 8, 2017
Completion: Feb 10, 2020
NCT03187678
Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertension
Start: Dec 4, 2017
Completion: May 29, 2018
NCT03389321
Clinical Study to Investigate Effect of Macitentan on Riociguat Pharmacokinetics
Start: Jan 9, 2018
Completion: Feb 6, 2018
NCT03496506
A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects
Start: Mar 5, 2018
Completion: May 18, 2018
NCT03417141
Valchlor in the Treatment of Lichen Planopilaris
Start: Apr 1, 2018
Completion: Aug 30, 2019
NCT03422328
A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.
Start: Apr 5, 2018
Completion: Dec 27, 2023
NCT03492177
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
Start: Jul 23, 2018
Completion: Dec 31, 2026
NCT03288818
Low Dose Total Skin Electron Beam Radiation Therapy and Mechlorethamine Hydrochloride Gel in Treating Patients With Mycosis Fungoides
Start: Aug 31, 2018
Completion: Dec 31, 2021
NCT04554160
Arrhythmias in Pulmonary Hypertension Assessed by Continuous Long-term Cardiac Monitoring
Start: Sep 24, 2018
Completion: Nov 1, 2024
NCT03714815
A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Start: Dec 7, 2018
Completion: Oct 12, 2021
NCT03809650
A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).
Start: Jan 8, 2019
Completion: Jun 29, 2020
NCT03689244
A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or Interventional Treatment
Start: Jan 23, 2019
Completion: Jun 7, 2022
NCT04729777
Assessment of Cardiac Function Using Combined Cardiovascular Magnetic Resonance and Cardiopulmonary Exercise Testing (CMR-CPET)
Start: Mar 1, 2019
Completion: Oct 1, 2021
NCT03775421
An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients.
Start: Apr 11, 2019
Completion: Jan 18, 2022
NCT03904693
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)
Start: Jul 29, 2019
Completion: Sep 27, 2024
NCT04211272
A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants
Start: Jan 14, 2020
Completion: Apr 19, 2021
NCT04175600
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
Start: Jan 16, 2020
Completion: Oct 1, 2027
NCT04266756
A Study of Selexipag in Healthy Male Participant
Start: Jan 23, 2020
Completion: Aug 14, 2020
NCT03910621
Safety and Efficacy of Miglustat in Chinese NPC Patients
Start: Apr 2, 2020
Completion: Mar 25, 2022
NCT04273945
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
Start: Jun 30, 2020
Completion: Feb 20, 2029
NCT04271475
A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension
Start: Jul 7, 2020
Completion: Dec 21, 2023
NCT04480723
A Study for the Identification of Biomarker Signatures for Diagnosis of Pulmonary Hypertension (PH) in Participants at Low or Intermediate Probability of PH Undergoing Cardiac Magnetic Resonance Imaging
Start: Dec 11, 2020
Completion: May 18, 2022
NCT05421949
Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAH
Start: Feb 19, 2021
Completion: Aug 30, 2022
NCT03942211
A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag
Start: Feb 26, 2021
Completion: Apr 19, 2023
NCT04565990
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Completion: Oct 5, 2021
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Completion: Dec 20, 2022
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