136
Participants
Start Date
March 30, 2017
Primary Completion Date
March 26, 2020
Study Completion Date
March 26, 2020
Ponesimod
One tablet of ponesimod 20 mg administered orally once daily in the morning from Day 15 to EOT. To reduce the first-dose effect of ponesimod, an uptitration scheme will be implemented from Day 1 to Day 14 (with dose strength increasing from 2 mg to 20 mg).
Placebo
One tablet of matching placebo administered orally once daily in the morning
MS Ambulanz Maida, Vienna
Medizinische Universität Wien, Universitätsklinik für Neurologie, Vienna
Hospital universitair Brussels_neurology department, Brussels
"Multiprofile Hospital for Active Treatment of Neurology and Psychiatry - Sveti Naum EAD - Neurology Clinic for Movement Disorders", Sofia
Uzsoki utcai Kórház, Neurológiai Osztály, Budapest
"University Multiprofile Hospital for Active Treatment - Alexandrovska EAD, Neurology Clinic", Sofia
"University Multiprofile Hospital for Active Treatment Sv. Ivan Rilski EAD, Neurology Clinic", Sofia
Pest Megyei Flór Ferenc Kórház, Neurológia és Stroke ambulancia, Kistarcsa
Valeomed EGÉSZSÉGÜGYI KÖZPONT, Esztergom
Glostrup Hospital, Neurologisk afdelning, Glostrup Municipality
Austin Health - Neuro-Immunology Clinical Research, Education and Support Service, Heidelberg
Hospital - Revalidatie & MS Centrum Overpelt_Neurology Department, Overpelt
Univeritätsspital Basel Neurologie, Neurologische Klinik und Poliklinik, Basel
Ospedale Regionale di Lugano - Civico e Italiano, Neurologia, Lugano, Lugano
Hospital - Universitair Gent __Neurology Department, Ghent
Aalborg Universitetshospital, Skleroseklinikken Neurologisk afdelning, Aalborg
NYU Langone Medical Center - MS Comprehensive Care Center, New York
Azienda Ospedaliero Universitaria San Luigi Gonzaga - Centro Sclerosi Multipla CRESM, Orbassano
Naval Hospital of Athens - Neurology Dpt, Athens
401 Military Hospital of Athens - Neurology Dept, Athens
Aeginition Hospital - Neurology Department, Athens
Unidad de Investigacion en Salud de Chihuahua SC, Médica Sur, Unidad de Neurociencias, Tlalpan
Medical Center of Athens - Neurology Dpt, Marousi
Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) - Neurology Department 2, Santiago de Compostela
AOU San Martino di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DINOGMI), Genova
Hospital Santa Caterina - Neurology Department, Salt
Universitätsmedizin Greifswald - Körperschaft des öffentlichen Rechts - Klinik und Poliklinik für Neurologie, Greifswald
Hospital of the University of Pennsylvania, Philadelphia
Thomas Jefferson University Hospital - Dpt Neurology MS Center, Philadelphia
Istituto Neurologico Carlo Besta, UOC Neurologia 4, Neuroimmunologia e Malattie Neuromuscolari, Centro Sclerosi Multipla, Milan
CHU de Dijon - Hôpital François Miterrand, Service de Neurologie, Dijon
Gemeinschaftspraxis Dr. med. Joachim Springub / Wolfgang Schwarz, Studienzentrum Nord-West (Study Center), Westerstede
Hosp Gregorio Marañón, Neurology, Madrid
Hospital Clinico San Carlos, Neurology, Madrid
Hôpital Universitaire Carémeau, Service de Neurologie, Nîmes
Hosp Virgen de la Arrixaca, Neurology, El Palmar
Medizinische Hochschule Hannover, Neurologie, Hanover
Unidad de Investigación de Salud en Chihuahua, Chihuahua City
Neurology Assoc of Ormond Beach - CNS Trials, Ormond Beach
Neurology Associates - MS Center of Greater Orlando, Maitland
The MS Center of Vero Beach, Vero Beach
Suncoast Neuroscience Associates, Inc, St. Petersburg
Bradenton Research Center, Bradenton
Hopital Gui de Chauliac - CHU Montpellier, Montpellier
Hosp Pontchaillou, Dept Cardiology, Rennes
UAB Dpt of Neurology, Birmingham
Universitätsklinikum Giessen Klinik und Poliklinik für Neurologie, Giessen
Advanced Neuroscience Institute, Franklin
Hospital Universitario Virgen Macarena - Neurofisiology Department, Seville
Centro de Neurologia Avanzada, Neurology, Seville
OhioHealth Research Institute, Columbus
Desarrollo Ético en Investigación Clínica S.C ., Guadalajara
Riverhills Healthcare, Inc., Cincinnati
Fort Wayne Neurological Center - North Office, Fort Wayne
Universitätsklinikum Münster, Klinik für Allgemeine Neurologie, Münster
Henry Ford Health System - Neurology, Detroit
Università degli Studi di Firenze - Azienda Ospedaliero Universitaria Careggi - CTO - SOD Neurologia 2, Florence
Azienda Ospedaliera Universitaria Senese - Dipartimento di Scienze Neurologiche e neurosensoriali - UOSA Neurologia Sperimentale, Siena
Hôpital Central - CHU Nancy, Département Neurologie, Nancy
General Hospital of Thessaloniki, Thessaloniki
Medizinzentrum Siegerland Weidenau, Siegen
CHRU de Lille - Hôpital Roger Salengro, Service de Neurologie, Lille
Zentrum für klinische Forschung Dr. med. Irma Schöll, Bad Homburg
Hosp Gabriel Montpied, Dept Neurology, Clermont-Ferrand
Axis Heilsa S. de R.L. de C.V. (Althian), Nuevo León
University of Kansas Med Center, Kansas City
MidAmerica Neuroscience Research Foundation/Rowe Neurology, Lenexa
Neurology and Neuromuscular Center, Oklahoma City
Hosp Charles Nicolle Dept Neurology, Rouen
Neurology Center of San Antonio, San Antonio
CHI POISSY-Saint Germay en Laye_Service de Neurologie et Réeducation, Poissy
University of Colorado Hospital, Aurora
"Azienda Ospedaliera Universitaria (AOU) Federico II - Centro Regionale Per la Sclerosi Multipla c/o Clinica Neurologica II - Dipartimento di Scienze", Napoli
AOU Università degli Studi della Campania L. Vanvitelli - I° Policlinico - DAI di Medicina Interna e Specialistica CS, Centro Sclerosi Multipla, Napoli
Mountain View Clinical Research, Inc, Denver
IRCCS NEUROMED - Istituto Neurologico Mediterraneo - Unità Operativa di Neurologia I, Pozzilli
Univ of New Mexico - Health Sciences Center, Albuquerque
NeuroPoint GmbH, Gesellschaft für vorbeugende Gesundheitspflege, Ulm
Fondazione Istituto San Raffaele , Unità Operativa di Neurologia, Cefalù
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance
Centre Hospitalier Sud Francilien - Service de Neurologie, Corbeil-Essonnes
SC3 Research - Pasadena, Pasadena
Care Access Research - Santa Clarita, Santa Clarita
Hôpital Avicenne, Service de Neurologie, Bobigny
Neuro-Pain Medical Center, Fresno
Helios Klinikum Erfurt, Erfurt
Moscow State Budgetary Healthcare Institution Filatov City Clinical Hospital No.15 of Moscow Health Department, Moscow
Neuro-Clinic, LLC, Moscow
Moscow State Budgetary Healthcare Institution Pirogov City Clinical Hospital No. 1 of Moscow Health Department, Moscow
Moscow State Budgetary Healthcare Institution City Clinical Hospital No. 24 of Moscow Health Department, Moscow
Center of Professional Therapy, LLC, Krasnodar
State Budgetary Healthcare Institution Regional Clinical Hospital No 3, Chelyabinsk
Associated Neurologists, Danbury
University of Alberta, Edmonton
Fakultní nemocnice u sv. Anny Brno, RS Centrum, Brno
Fakultní nemocnice Hradec Králové, Neurologická klinika, Hradec Králové
Nemocnice Jihlava, Neurologické oddělení, Jihlava
Pardubicka krajska nemocnice, MS Centrum, Pardubice
Krajská zdravotní a.s. - Nemonice Teplice o.z., RS Centrum, Teplice
Neurologische Klinik und Poliklinik - Universitätsklinikum Carl Gustav Carus, Zentrum für klinische Neurowissenschaften, Dresden
AFL Arzneimittelforschung Leipzig GmbH, Leipzig
Azienda Ospedaliera S. Andrea di Roma - Unità Operativa Complessa di Neurologia, Roma
Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Neurologii i Oddziat Udarowy, Bialystok
B&B Robert Bonek, Pawel Bochniak S.C, Bydgoszcz
COPERNICUS - Podmiot Leczniczy Sp. z o.o., Gdansk
Centrum Terapii SM, Katowice
Neuro-Medic Janusz Zbrojkiewicz Poradnia Weilospecjalistyczna, Katowice
Centrum Kompleksowej Rehabilitacji, Konstancin-Jeziorna
Centrum Opieki Zdrowotnej Orkan - Med., Ksawerów
Instytut Psychiatrii i Neurologii, II Klinika Neurologiczna, Warsaw
WroMedica, J. Bielicka A. Strzałkowska SC, Wroclaw
Centro Hospitalar de Lisboa Central, Lisbon
Hospital de Santa Maria - Neurology Department, Lisbon
Centro Hospitalar de São João, E.P.E. - Hospital de São João - Neurology Department, Porto
Hospital Santa Creu I Sant Pau - Neurology Dpt, Barcelona
Queen Square MS Centre / NMR research Unit UCL Institute of Neurology, London
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford
Royal Hallamshire Hospital, Sheffield
University Hospitals of North Midlands NHS Trust, Stoke-on-Trent
Lead Sponsor
Actelion
INDUSTRY