A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or Interventional Treatment

PHASE3TerminatedINTERVENTIONAL
Enrollment

128

Participants

Timeline

Start Date

January 23, 2019

Primary Completion Date

June 7, 2022

Study Completion Date

June 7, 2022

Conditions
Chronic Thromboembolic Pulmonary Hypertension
Interventions
DRUG

Selexipag

oral tablets containing 200 µg of selexipag. Depending on the iMTD, participants will receive 1 to 8 tablets at each administration

DRUG

Placebo

Oral tablets without active compound

Trial Locations (162)

100

National Taiwan University Hospital, Taipei

704

National Cheng Kung University Hospital, Tainan City

813

Kaohsiung Veterans General Hospital, Kaohsiung City

1070

ULB Hôpital Erasme, Brussels

1083

Semmelweis Egyetem,Pulmonológiai Klinika, Budapest

1090

Medical University Vienna, Vienna

1096

Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály, Budapest

1392

National Cardiology Hospital, Sofia

1750

University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD, Sofia

2010

St Vincent's hospital, Darlinghurst

2100

Rigshospitalet Kardiologisk Klinisk, Copenhagen

2145

Westmead Hospital, Westmead

3000

UZ Leuven, Leuven

3004

The Alfred Hospital, Melbourne

3080

Seoul National University Hospital, Seoul

4020

Ordensklinikum Linz GmbH Elisabethinen, Linz

4032

Queensland Lung Transplant Service, Chermside

Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum, Debrecen

5000

Royal Adelaide Hospital, Adelaide

5800

UMHAT 'Heart and Brain Center for Excellence', Pleven

6100

Hacettepe University Medical Faculty, Ankara

6500

Ankara University Medical Faculty, Ankara

6720

Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet és rendelő, Szeged

7000

Pulmonary Arterial Hypertension Clinic, Hobart

7624

Pecsi Tudomanyegyetem Klinikai Kozpont, Pécs

8035

Hosp. Univ. Vall D Hebron, Barcelona

8091

Universitatsspital Zurich, Zurich

8200

Århus Universitetshospital, Skejby, Hjertemedicinsk Afdeling B, Aarhus

10400

Ramathibodi Hospital Mahidol University, Bangkok

10990

Hospital Pulau Pinang, George Town

14000

Instituto Nacional de Cardiologia Dr. Ignacio Chavez, Mexico City

15212

Allegheny, Pittsburgh

15213

University of Pittsburgh Medical Center, Pittsburgh

17475

Universität Greifswald - Klinik Für Innere Medizin Bereich Pneumologie/Infektiologie, Greifswald

20246

Universitätsklinikum Hamburg-Eppendorf - Pneumologie, Hamburg

21201

University of Maryland, Baltimore

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27710

Duke University Medical Center, Durham

28041

Hosp. Univ. 12 de Octubre, Madrid

30309

Piedmont Healthcare, Atlanta

30322

Emory University, Atlanta

30625

Medizinische Hochschule Hannover Zentrum Innere Medizin Klinik für Pneumologie, Hanover

32259

Mayo Clinic in Florida, Jacksonville

34093

Istanbul University Istanbul Medical Faculty, Istanbul

34096

Istanbul University Cerrahpasa Medical Faculty, Istanbul

34149

Ospedale di Cattinara - Struttura complessa di Pneumologia, Trieste

34865

Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi, Kartal Istanbul

34899

Marmara University Medical Faculty, Istanbul

35100

Ege University Medical Faculty, Izmir

35392

Universitätsklinikum Giessen Medizinische Klinik Und Poliklinik Ii, Pneumologie, Giessen

39011

Hosp. Univ. Marques de Valdecilla, Santander

40002

Srinagarind Hospital, Khon Kaen University, Khon Kaen

40138

Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna

40447

China Medical University Hospital, Taichung

41013

Hosp. Virgen Del Rocio, Seville

43000

Hospital Serdang, Kajang

44160

CICUM San Miguel, Guadalajara

44195

Cleveland Clinic, Cleveland

45267

University of Cincinnati Medical Center, Cincinnati

46026

Hosp. Univ. I Politecni La Fe, Valencia

48109

University of Michigan, Ann Arbor

48912

Sparrow Clinical Research Institute, Lansing

49059

CE 'Dnipropetrovsk Regional Clinical Center of Cardiology and Cardiosurgery', Dnipro

49241

Pusan National University Hospital, Busan

50400

Institut Jantung Negara (National Heart Institute), Kuala Lumpur

53211

Medical College of Wisconsin Froedtert Hospital, Milwaukee

53215

Aurora Saint Lukes Medical Center, Milwaukee

55905

Mayo Clinic, Rochester

60453

Advocate Christ Medical Center, Oak Lawn

60611

Northwestern University Feinberg School of Medicine, Chicago

60637

University of Chicago Hospitals - Chicago, Chicago

63110

Washington University in St. Louis, St Louis

64718

Unidad de Investigacion Clinica en Medicina S.C. (UDICEM), Monterrey

66421

Universitätskliniken des Saarlandes / Medizinische Klinik und Poliklinik, Innere Medizin V, Homburg/Saar

68198

University of Nebraska Medical Center, Omaha

69126

Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg

75093

Baylor Scott & White Research Institute at The Heart Hospital Baylor Plano, Plano

75390

University of Texas Southwestern Medical Center, Dallas

77030

Houston Methodist Hospital, Houston

79000

Lviv Regional Clinical Hospital, Lviv

80045

University of Colorado Anschutz Medical Campus, Aurora

80120

South Denver Cardiology Associates PC, Littleton

80907

Colorado Springs Pulmonary Consultants, Colorado Springs

84132

University of Utah Cardiovascular Center, Salt Lake City

84175

Intermountain Medical Center, Murray

87131

University of New Mexico Clinical & Translational Science Center, Albuquerque

89503

St. Mary's Cardiology, Reno

90033

University of Southern California, Keck School of Medicine, Los Angeles

92037

University of California San Diego Medical Center, La Jolla

97074

Klinikum Würzburg Mitte gGmbH Standort Missioklinik, Würzburg

100730

Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC), Beijing

110000

The General Hospital of Northern Theater Command, Shenyang

110022

Shengjing Hospital Of China Medical University, Shenyang

119049

Moscow City Clinical Hospital #1 n.a. N.I.Pirogov, Moscow

121309

Moscow City Clinical Hospital No.51, Moscow

121552

National Medical Research Center of Cardiology of MoH of Russian Federation, Moscow

197341

National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation, Saint Petersburg

300052

Tianjin Medical University General Hospital, Tianjin

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

630055

E.Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk

650002

Cardiovascular Pathology Research Institute of Siberian Branch of RAMS, Kemerovo

664049

Irkutsk Regional Clinical Hospital, Irkutsk

4941492

Rabin Medical Center Beilinson Campus, Petah Tikva

5265601

The Chaim Sheba Medical Center, Tel Litwinsky

19140-5103

Temple University Hospital, Philadelphia

C1039AAO

Sanatorio de la Trinidad Mitre, Buenos Aires

C1426ABP

Centro Médico Dra. De Salvo, Buenos Aires

1199ABB

Hospital Italiano de Buenos Aires, Caba

C1048AAN

Sanatorio Ramon Cereijo, Caba

C1093AAS

Instituto de Cardiología y Cirugía Cardiovascular - Fundación Favaloro, Caba

C1155AHD

Hospital General de Agudos Dr Cosme Argerich, CABA

C1280AEB

Hospital Britanico de Buenos Aires, CABA

30130-100

Universidade Federal De Minas Gerais - Hospital das Clínicas, Belo Horizonte

30441-070

Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa, Belo Horizonte

18618-686

Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu), Botucatu

60840-285

Secretaria da Saude do Estado do Ceara - Hospital Doutor Carlos Alberto Studart Gomes, Fortaleza

74605-020

Universidade Federal de Goias - Hospital das Clinicas da UFG, Goiânia

90020-090

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90035-003

Hospital das Clinicas de Porto Alegre, Porto Alegre

90610-000

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre

09060-870

Fundacao do ABC - Centro Universitario FMABC, Santo André

04037-003

SPDM - Associacao Paulista para o Desenvolvimento da Medicina - Hospital Sao Paulo, São Paulo

05403-000

Hospital Das Clinicas Da Faculdade De Medicina Da USP, São Paulo

T1Y 6J4

University Of Calgary - Peter Lougheed Centre, Calgary

V5Z 1M9

Vancouver General Hospital, Vancouver

N6A 5W9

London Health Sciences Centre - Victoria Hospital, London

H3T 1E2

Jewish General Hospital, Montreal

G1V 4G5

Institut Universitaire De Cardiologie Et De Pneumologie De Québec, Québec

030001

Shanxi Cardiovascular Hospital, Taiyuan

128 08

General University Hospital II.department of Internal Medicine-cardiology and angiology, Prague

01307

Universitätsklinikum Carl Gustav Carus Medizinische Klinik und Poliklinik 1-Pneumologie, Dresden

04103

Universitätsklinikum Leipzig Medizinischen Klinik und Poliklinik I, Abteilung für Pneumologie, Leipzig

00161

Policlinico Umberto I, Roma

1081 HV

VUMC Amsterdam, Amsterdam

3435 CM

St. Antonius Ziekenhuis Nieuwegein, Nieuwegein

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

31-202

Krakowski Szpital Specjalistyczny im Jana Pawla II, Krakow

20-718

Wojewodzki Szpital Specjalistyczny im. Stefana Kardynala Wyszynskiego SPZOZ, Lublin

05-400

NZOZ Europejskie Centrum Zdrowia Otwock, Otwock

61-848

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznan

70-111

Samodzielny Publiczny Szpital Kliniczny nr 2 PUM, Szczecin

02-005

Warszawski Uniwersytet Medyczny, Szpital Kliniczny Dzieciątka Jezus, Warsaw

51-124

Wojewodzki Szpital Specjalist, Osrodek Badawczo-Rozwojowy, Wroclaw

2801-951

Hospital Garcia de Orta, Almada

3000-075

Hospitais da universidade de Coimbra, Coimbra

1649-028

Centro Hospitalar de Lisboa Norte, Lisbon

4099-001

Hospital Geral de Santo Antonio, Porto

833 48

Narodny ustav srdcovych a cievnych chorob, Bratislava

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08036

Hosp Clinic de Barcelona, Barcelona

901 85

Norrlands Universitetssjukhus, Umeå

751 85

Uppsala Akademiska Sjukhuset, Kardiologkliniken, Uppsala

02000

SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine, Kyiv

03038

SI 'National Institute of Phtisiology and Pulmonology n.a. F.G. Yanovsky of NAMS of Ukraine', Kyiv

CB2 0AY

Papworth Hospital NHS Trust, Cambridge

G81 4DY

National Waiting Times Centre Board Golden Jubilee National Hospital, Glasgow

NW3 2QG

Royal Free Hospital, London

SW3 6NP

Royal Brompton Hospital, London

W12 0HS

Hammersmith Hospital, London

S10 2RX

Sheffield Teaching Hospitals NHS Foundation Trust Royal Hallamshire Hospital, Sheffield

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