158
Participants
Start Date
August 31, 2003
Primary Completion Date
September 30, 2005
Study Completion Date
May 31, 2010
bosentan
"Initial dose: 62.5 mg b.i.d. for 4 weeks.~* Target dose: - body weight \> 40 kg (90 lb): 125 mg b.i.d., (if the initial dose is well tolerated).~* body weight \< 40 kg (90 lb): 62.5 mg b.i.d."
Placebo
"Initial dose: 62.5 mg b.i.d. for 4 weeks.~* Target dose: - body weight \> 40 kg (90 lb): 125 mg b.i.d., (if the initial dose is well tolerated).~* body weight \< 40 kg (90 lb): 62.5 mg b.i.d."
University of Pittsburgh, Pittsburgh
University of Pennsylvania, Philadelphia
Jackson Memorial Hospital, Miami
University of Alabama at Birmingham - Pulmonary Division, Birmingham
Vanderbilt University Medical Center, Nashville
Médecine Spécialisée Aigüe - CHU Grenoble, Grenoble
University of Michigan Health System - Division of Pulmonary & Critical Care Medicine, Ann Arbor
University of Iowa Hospitals & Clinics - Department of Internal Medicine, Iowa City
University of Wisconsin Hospitals & Clinics - Section of Pulmonary and Critical Care Medicine, Madison
Mayo Medical School - Mayo Clinic, Rochester
Hôpital Louis Pradel, Lyon
Baylor College of Medicine, Houston
National Jewish Medical and Research Center, Denver
David Geffen School of Medicine at UCLA - Division of Pulmonary and Critical Care Medicine, Los Angeles
UCSD Medical Center, San Diego
University of California - Ambulatory Care Center, San Francisco
University of Washington - Division of Pulmonary & Critical Care Medicine, Seattle
Yale University School of Medicine, New Haven
University of British Columbia - St. Paul's Hospital, Vancouver
Rosedale Medical Center, Toronto
Notre-Dame Hospital - Clinique du Thorax, Montreal
Hôpital Avicenne - Université de Paris, Bobigny
Abt. Pneumologie Medizinische Klinik Universitätsklinikum Freiburg, Freiburg im Breisgau
Klinik Löwenstein gGmbH, Löwenstein
Medizinische Klinik und Poliklinik I Klinikum der Universität München, München
Sheba Medical Center, Tel Litwinsky
Section of Respiratory Diseases - Policlinico Le Scotte - Siena University, Siena
Inselspital, Bern
Royal Brompton Hospital, London
Lead Sponsor
Actelion
INDUSTRY