742
Participants
Start Date
May 31, 2008
Primary Completion Date
March 31, 2012
Study Completion Date
April 30, 2012
macitentan (ACT-064992)
Tablet, 3 mg dosage, once daily
macitentan (ACT-064992)
Tablet, 10 mg dosage, once daily
placebo
Matching placebo, once daily
Specialized Hospital for Active Treatment of Cardio-Vascular Diseases / Department of Pediatric Cardiology, Sofia
Netcare Milpark Hospital,Center for Chest Disease, Johannesburg
St. Vincent's Hospital, Darlinghurst, NSW
The Alfred Hospital, Melbourne, VIC
Royal Brisbane Hospital, Sunshine Coast
Block 4, Vergelegen Medi-Clinic, Somerset West
Tread Research, Parow
Ramathibodi Hospital, Mahidol University, Cardiology Unit, Department of Medicine,, Bangkok
Siriraj Hospital/ Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok
University Children's Hospital (UNIVERZITETSKA DEČJA KLINIKA), Belgrade
University Clinical Center of Serbia / Institute for Lung Diseases and Tuberculosis, Belgrade
"Zemun Clinical Hospital (Kliničko-bolnički centar Zemun ) / Department of Cardiology", Belgrade
'Instituto Nacional de Cardiología (INC) Ignacio Chávez, Mexico City
Hospital Juan Canalejo Servicio de Neumología, A Coruña
Hospital 12 Octubre/ Cardiology department Planta 5a., Madrid
University of Maryland School of Medicine, Baltimore
Sentara Hospital T/A Sentara Cardiovascular Research Institute, Norfolk
Hospital Clínico Virgen de la Victoria / Pneumology Unit,, Málaga
Emory University Hospital - McKelvey Center for Lung Transplantation & Pulmonary Vascular Disease, Atlanta
Pulmonary & Critical Care of Atlanta, Atlanta
Hopital Haut-Leveque - Maison du Haut-Leveque, Pessac
Hôpital Arnaud de Villeneuve Service des Maladies Respiratoires, Montpellier
Lady Davis Carmel Medical Center / Department of Cardiovascular Medicine, Pulmonary Division, Haifa
Hospital Montecelo, Servicio de Neumología, Pontevedra
Srinagarind Hospital/Division of Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen
Taichung Veterans General Hospital / Division of Allergy, Immunology and Rheumatology, Taichung
Ohio State University, Columbus
Dnipropetrovsk State Medical Academy / Regional Diagnostic Center, Department of electrophysiologic researches and anaesthesiologic aid, Dnipro
Rabin Medical Center - Belinson campus - Pulmonary Institute, Petach - Tikvah
"Institutul de Pneumologie Marius Nasta / I. Clinica de Pneumoftiziologie", Bucharest
Institut Jantung Negara (National Heart Institute), Kuala Lumpur
The pulmonary institute Sheba Medical centre, Tel Litwinsky
Washington University School of Medicine, St Louis
Unidad de Investigación Clinica en Medicina, SC, Monterrey Nuevo León
Sourasky Medical Center - Division of Pulmonary Medicine and Allergy, Tel Aviv
University of Kansas Medical Center, Kansas City
University of Texas Medical Center - St. Paul University, Dallas
Pulmonary Institute, Kaplan Medical Center, Rehovot
Baylor College of Medicine and the Methodist Hospital, Houston
Danylo Halytskyi Lviv State Medical University, Lviv
Arizona Pulmonary Specialists, Pheonix
Hôpital Antoine Béclère / Service de Pneumologie, Clamart
Universitätsklinikum Regensburg / Innere Medizin II, Regensburg
Beijing Anzhen Hospital of the Capital University of Medical Sciences, Cardiology Department, Beijing
Peking Union Medcical College Hospital, Rheumatology Department, Beijing
Chinese PLA General Hospital (301 Hospital), Cardiology Department, Beijing
"Federal State Institution Scientific Research Institute of Pulmonology of Roszdrav", Moscow
G B Pant Hospital & Maulana Azad Medical College, Delhi
"State Health Care Institution of Moscow City Clinical Hospital #1 named after N. I. Pirogov", Moscow
"Federal State Institution Russian Cardiology Scientific and Production Complex of Rosmedtechnology", Moscow
National University Hospital/ The Heart Institute, Singapore
Singapore General Hospital, Singapore
"Federal State Institution Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov of Rosmedtechnology", Saint Petersburg
Renji Hospital, Rheumatology Dept, Shanghai
Zhongshan Hospital Fudan University, Cardiology Dept, Shanghai
Renji Hospital, Cardiology Dept, Shanghai
Shanghai Pulmonary Hospital, Dept of Pulmonary Circulation, Shanghai
Jiangsu Province Hospital - Pneumology Department, Nanjing
Vitebsk Regional Clinical Hospital, Vitebsk
Republican reserach - Pratical Centre of Cardilogy, Minsk
Minsk Regional Clinical Hospital, Minsk
Life Care Institute of Medical Science & Research, Ahmedabad, Ahmedabad
P D Hinduja National Hospital and Medical Research Centre/ Pulmunory Medicine, Mumbai
Care Hospital, Hyderabad
Guangdong General Hospital, Cardiology Department, Guangzhou
Sverdlovsk Regional Clinical Hospital # 1/ Cardiology Department (2nd Therapy Department), Yekaterinburg
"State Institution Scientific Research Institute of Cardiology of Tomsk Scientific Center of RAMS, Siberian branch", Tomsk
Tomsk Regional Clinical Hospital / Pulmonology Unit, Tomsk
"Municipal Health Care Institution Kemerovo Cardiology Dispensary", Kemerovo
University of Alabama at Birmingham, Birmingham
GLVA Healthcare Center, Los Angeles
University of California, San Diego, San Diego
Santa Barbara Cottage Hospital, Santa Barbara
Liu Center for Pulmonary Hypertension, Torrance
University of Colorado Health Sciences Center, Denver
Mayo Clinic, Jacksonville, Jacksonville
Southeastern Lung Care, Decatur
University of Chicago Hospitals, Chicago
University of Iowa, Iowa City
Kentuckiana Pulmonary Associate, PLLC, Louisville
Medical Center of Louisiana at New Orleans, New Orleans
Boston University School of Medicine, Boston
Pulmonary/Critical Care Division/Tufts New England Medical Center, Boston
University of Michigan, Ann Arbor
University of NJ - Robert Wood Johnson Medical School, New Brunswick
Columbia University Medical Center - Pediatric Cardiology, New York
Duke University Medical Center, Durham
University of Cincinnati Ohio Heart Health Center, Cincinnati
Vanderbilt University Medical Center, Nashville
Dept. of Pulmonary Medicine - Latter Day Saints Hospital, Salt Lake City
Comprehensive Cardiovascular Care Group, Milwaukee
Hospital Britanico, Buenos Aires
Sanatorio MITRE, Buenos Aires
SANATORIO OTAMENDI y MIROLI, Buenos Aires
Instituto Cardiologia Corrientes, Corrientes
Htal Italiano Cordoba, Córdoba
Htla privado de Cordoba, Córdoba
'Hospital Italiano - Garibaldi de Rosario, Santa Fe
Medical University of Vienna/ Department of Internal Medicine II, Division of Cardiology, Vienna
University Hospital Gasthuisberg / Kliniekhoofd, Interne Geneeskunde - I.G. Pneumologie, Leuven
London Health Sciences Centre / Victoria Hospital, London
L'Hopital Laval, Saint-Foy
Peter Lougheed Centre, Calgary
Toronto General Hospital, Toronto
'Pontificia Universidad Catolica de Chile, Santiago
Hospital del Torax, Santiago
Hospital San Juan de Dios, Santiago
Fundación Clínica Shaio, Bogotá
'Fundacion Cardiovascular de Colombia, Floridablanca, Santander
Unfallkrankenhaus Berlin, Klinik für Innere Medizin, Berlin
Prince of Wales Hospital/ Division of Rheumatology, Department of Medicine & Therapeutics, Hong Kong
Queen Mary Hospital / Division of Cardiology, Department of Medicine, Hong Kong
University of Szeged Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of General Medicine, II. Internal Medicine Clinic, Cardiology Center, Szeged
Hospital Alberto Sabogal Sologuren - EsSALUD, Lima
IInstituto de Enfermedades Respiratorias, Clinica San Gabriel, Lima
National Taiwan University Hospital/ Thoracic Surgical Division, Surgical Department, Taipei
Chiang Mai Hospital / Division of Rheumatology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai
Istanbul University Cardiology Institure, Istanbul
Maine Medical Center, Portland
Fundacion Favaloro, Buenos Aires
Vancouver General Hospital, Vancouver
Clinical Hospital Center, Rijeka
Universität zu Köln, Medizinische Klinik III, Abteilung Kardiologie, Cologne
Medizinische Klinik und Poliklinik I Universitätsklinikum Carl Gustav Carus, Dresden
Universitätsklinikums Gießen und Marburg GmbH / Medizinische Klinik und Poliklinik II, Innere Med., Giessen
Universität Greifswald / Klinik für Innere Medizin B,, Greifswald
Universitätsklinikum Hamburg-Eppendorf / Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Hamburg
Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg
Universitätskliniken des Saarlandes / Medizinische Klinik und Poliklinik, Innere Medizin V, Homburg/Saar
Universtätsklinik Leipzig, Leipzig
Klinikum der Johannes Gutenberg-Universität / II. Medizinische Klinik und Poliklinik, Mainz
Medizinische Klinik und Poliklinik I der Ludwig-Maximilians-Universität München / Klinikum Großhadern, Schwerpunkt Pneumologie, Munich
Gottsegen György Országos Kardiológiai Intézet (Hungarian Institute of Cardiology), Budapest
Semmelweis University, Pulmonolgy Clinic, Budapest
King Edward VII Memorial Hospital (KEM) Hospital, Mumbai
Deenanath Mangeshkar Hospital and Research Centre, Pune
Policlinico Umberto I, Cardiologia, Roma
St. Antonius ziekenhuis, Nieuwegein
Aker University Dept of Cardilogy, Oslo
Klinika Chorob Serca i Naczyn Instytut Kardiologii Collegium Medicum UJ, Krakow
Klinika Chorób Wewnętrznych Klatki Piersiowej, Warsaw
III Katedra i Oddział Kliniczny Kardiologii Slaskiego Uniwersytetu Medycznego, Zabrze
Institutul de boli cardiovasculare / Clinica de Cardiologie, Bucharest
State Educational Institution of High Professional Education, Saint Petersburg
"Municipal Health Care Institution Clinical Hospital of Emergency Care named after N.V. Soloviov", Yaroslavl
National Institute of Cardiovascular Diseases (Národný ústav srdcových a cievnych chorôb, a.s. - NÚSCH) / Department of Heart Transplantation, Bratislava
Slovak Medical University (Slovenská zdravotnícka univerzita) / Faculty of Medical Speciality Studies (Fakulta zdravotníckych špecializačných štúdií), Department of Cardiology and Angiology, Bratislava
Chris Hani Baragwanath Hospital, Department of Cardiology, Johannesburg
Hospital Universitario Vall d'Hebron, Pneumology Unit, Planta Baja Hospital General, Barcelona
Hospital Clínico I Provincial, Servicio de Neumología., Barcelona
University Hospital in Lund, Heart and Lung Division, Lund
Servicio de Medicina Interna, Unidad de Hipertensión Pulmonar, Uppsala
Royal Free Hospital, London
Lead Sponsor
Actelion
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