Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension

PHASE3CompletedINTERVENTIONAL
Enrollment

550

Participants

Timeline

Start Date

October 17, 2008

Primary Completion Date

December 7, 2020

Study Completion Date

December 7, 2020

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Macitentan

Tablet, oral administration, 10 mg dose once daily

Trial Locations (158)

31

Clinica Medica Cayetano Heredia, Lima

32

Instituto de Enfermedades Respiratorias, Lima

100

National Taiwan University Hospital/ Thoracic Surgical Division, Surgical Department, Taipei

1090

Medical University of Vienna/ Department of Internal Medicine II, Division of Cardiology, Vienna

1096

Gottsegen György Országos Kardiológiai Intézet (Hungarian Institute of Cardiology), Budapest

1125

"Semmelweis Egyetem, Pulmonológiai Klinika", Budapest

1309

Mhat Nat Card Hosp - Pediatric Clinic, Sofia

2010

St. Vincent's Hospital, Darlinghurst

2013

Chris Hani Baragwanath Hospital, Department of Cardiology, Johannesburg

2193

Netcare Milpark Hospital,Center for Chest Disease, Johannesburg

3000

University Hospital Gasthuisberg, Leuven

3004

The Alfred Hospital, Melbourne

4558

Royal Brisbane Hospital, Sunshine Coast

6720

University of Szeged Albert Szent-Gyorgyi Medical & Pharmaceutical Center, Szeged

7130

Block 4, Vergelegen Medi-Clinic, Somerset West

7505

Tread Research, Cape Town

7624

University of Pecs, Medical School/Heart Institute and 1st Department of Internal Medicine, Pécs

10032

Columbia University Medical Center - Pediatric Cardiology, New York

10400

Ramathibodi Hospital, Mahidol University, Cardiology Unit, Department of Medicine,, Bangkok

10700

Siriraj Hospital, Mahidol University, Bangkok

11000

University Children's Hospital (UNIVERZITETSKA DECJA KLINKIKA), Belgrade

University Clinical Center of Serbia/ Institute for Lung Diseases and Tuberculosis, Belgrade

11080

Zemun Clinical Hospital (Klinicko-bolnicki centar Zemun) / Department of Cardiology, Belgrade

12683

Unfallkrankenhaus Berlin, Klinik für Innere Medizin, Berlin

14080

Instituto Nacional de Cardiología (INC) Ignacio Chávez, Mexico City

15212

Allegheny General Hospital, Pittsburgh

17475

Universität Greifswald / Klinik für Innere Medizin B,, Greifswald

20246

Universitätsklinikum Hamburg-Eppendorf / Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Hamburg

30030

Atlanta Institute for Medical Research, Decatur

30322

Emory University Hospital - McKelvey Center for Lung Transplantation & Pulmonary Vascular Disease, Atlanta

30625

Medizinische Hochschule Hannover / Klinik für Pneumologie, Hanover

31096

Rambam Health Care Campus / Division of Medicine, Institute of Pulmonology, Haifa

32259

Mayo Clinic, Jacksonville, Jacksonville

32610

University of Florida - Division of Pulmonology, Gainesville

33604

Hopital Haut-Leveque-Maison du Haut-Leveque, Pessac

34295

Hopital Arnaud de Villeneuve Service des Maladies Respiratoires, Montpellier

34362

Lady Davis Carmel Medical Center / Department of Cardiovascular Medicine, Pulmonary Division, Haifa

35392

Universitätsklinikums Gießen und Marburg GmbH / Medizinische Klinik und Poliklinik II, Innere Med. / Pneumologie, Giessen

37232

Vanderbilt University Medical Center, Nashville

40002

Srinagarind Hospital/Division of Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen

40202

Kentuckiana Pulmonary Associate, PLLC, Louisville

40705

Taichung Veterans General Hospital, Taichung

43210

Ohio State University, Div. of Pul. & Critical Care, Columbus

45122

Universitätsklinikum Essen, Klinik für Kardiologie , Zentrum für Innere Medizin, Essen

48109

University of Michigan, Ann Arbor

48201

Harper Univ. Hospital/ Wayne State University, Detroit

49060

Dnipropetrovsk State Medical Academy / Regional Diagnostic Center, Department of electrophysiologic researches and anaesthesiologic aid, Dnipro

49100

Rabin Medical Center - Belinson campus - Pulmonary Institute, Petach - Tikvah

50200

Maharaj Nakorn Chiang Mai Hospital, Division of Rheumatology, Chiang Mai

50400

Institut Jantung Negara (National Heart Institute), Kuala Lumpur

50924

Universität zu Köln, Medizinische Klinik III, Abteilung Kardiologie, Cologne

52621

The pulmonary institute Sheba Medical centre, Tel Litwinsky

53125

Aurora St. Luke's Medical Center, Milwaukee

64239

Sourasky Medical Center - Division of Pulmonary Medicine and Allergy, Tel Aviv

64718

Unidad de Investigación Clinica en Medicina, Monterrey

65044

Odessa State Medical University, Military-medical Clinical Center of the South region, Odesa

66160

University of Kansas Medical Center, Kansas City

66421

Universitätskliniken des Saarlandes / Medizinische Klinik und Poliklinik, Innere Medizin V, Homburg/Saar

68198

University of Nebraska Medical Center, Omaha

69126

Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg

76100

Pulmonary Institute, Kaplan Medical Center, Rehovot

77030

Baylor College of Medicine and the Methodist Hospital,, Houston

University of Texas Houston Health Center, Houston

79010

Danylo Galytskyi Lviv State Medical University, Lviv

81377

Medizinische Klinik und Poliklinik I der Ludwig-Maximilians-Universität München / Klinikum Großhadern, Schwerpunkt Pneumologie, Munich

85012

Arizona Pulmonary Specialists, Phoenix

90073

GLVA Healthcare Center, Los Angeles

92037

University of California, San Diego, La Jolla

93053

Universitatsklinikum Regensburg/Innere Medizin II, Regensburg

93105

Santa Barbara Cottage Hospital, Santa Barbara

94275

Hosp Bicetre - Dept Pulmo & Resp Intensive Care, Le Kremlin-Bicêtre

100029

Beijing Anzhen Hospital of the Capital University of Medical Sciences, Cardiology Department, Beijing

100032

Peking Union Medical College Hospital, Rheumatology Department, Beijing

101990

"Federal State Institution State Scientific Research Centre of Preventive Medicine of Rosmedtechnology", Moscow

105077

"Federal State Institution Scientific Research Institute of Pulmonology of Roszdrav", Moscow

117049

"State Health Care Institution of Moscow City Clinical Hospital #1 named after N. I. Pirogov", Moscow

119228

National University Hospital/ The Heart Institute, Singapore

121552

"Federal State Institution Russian Cardiology Scientific and Production Complex of Rosmedtechnology", Moscow

169609

National Heart Centre (Nhc) Singapore, Singapore

193015

"State Educational Institution St Petersburg Medical Academy of Postgraduate Education of Federal Agency of Public Health and Social Development", Saint Petersburg

197341

"Federal State Institution Federal Center of Heart, Blood and Endocrinology named after V.A. Almazov of Rosmedtechnology", Saint Petersburg

200001

Renji Hospital, Rheumatology Department, Shanghai

200032

Zhongshan Hospital Fudan University, Cardiology Department, Shanghai

200127

Renji Hospital, Cardiology Department, Shanghai

200433

Shanghai Pulmonary Hospital Department of Pulmonary Circulation, Shanghai

207100

IRCCS Policlinico San Matteo Policlinico / Dipartimento di Cardiologia, Pavia

210029

Jiangsu Province Hospital - Pneumology Department, Nanjing

210037

Vitebsk Regional Clinical Hospital, Vitebsk

220036

Republican reserach - Pratical Centre of Cardiology, Minsk

223041

Minsk Regional Clinical Hospital, Minsk

382428

Life Care Institute of Medical Science & Research, Ahmedabad, Ahmedabad

400012

Seth GS Medical College & King Edward VII Memorial (KEM) Hospital / Department Of Cardiology, Mumbai

400016

P D Hinduja National Hospital and Medical Research Centre/ Pulmunory Medicine, Mumbai

500001

Care Hospital, Hyderabad

510080

Guangdong General Hospital, Cardiology Department, Guangzhou

620102

Sverdlovsk Regional Clinical Hospital # 1/ Cardiology Department (2nd Therapy Department), Yekaterinburg

634012

"State Institution Scientific Research Institute of Cardiology of Tomsk Scientific Center of RAMS, Siberian branch", Tomsk

634063

Tomsk Regional Clinical Hospital / Pulmonology Unit, Tomsk

650002

Municipal Health Care Institution Kemerovo Cardiology Dispensary, Kemerovo

833034

Pontificia Universidad Catolica de Chile, Santiago

7500691

Hospital del Torax, Santiago

8350488

Hospital San Juan de Dios, Santiago

35249-0001

University of Alabama at Birmingham, Birmingham

90502-2006

Liu Center for Pulmonary Hypertension, Torrance

80045-2548

University of Colorado CARDIAC AND VASCULAR CENTER, Aurora

30342-1713

Pulmonary & Critical Care of Atlanta, Atlanta

60637-1432

University of Chicago, Chicago

52242-1081

University of Iowa, Pulmonary Hypertension Program, Iowa City

70112-1393

Louisiana State University Health Sciences Center, New Orleans

04102-3134

Maine Medical Center, Portland

21201-1544

University of Maryland School of Medicine; Division of Cardiology, Baltimore

02111-1552

Pulmonary/Critical Care Division/Tufts New England Medical Center, Boston

02114

Massachusetts General Hospital, Boston

02118

Boston University School of Medicine, Boston

63110-1010

Washington University School of Medicine, St Louis

08903-0010

University of NJ - Robert Wood Johnson Medical School, New Brunswick

27710-0001

Duke University Medical Center, Durham

45219-2906

University of Cincinnati Ohio Heart Health Center, Cincinnati

75390-8550

University of Texas Medical Center - St. Paul University, Dallas

84157-5701

Intermountain Med Ctr- Pulm Dept Heart and Lung Ctr, Murray

23507-1904

Sentara Hospitals T/A Sentara Cardiovascular Research Intitute, Norfolk

C1121ABL

Sanatorio Otamendi y Miroli S.A., Buenos Aires

C1280AEB

Hospital Britanico, Buenos Aires

C1039AAO

Sanatorio MITRE, Buenos Aires

C1093AAS

Fundacion Favaloro, Buenos Aires

W3400AMZ

Instituto Cardiologia Corrientes, Corrientes

X5004BAL

Htal Italiano Cordoba, Córdoba

x5016keh

Htla privado de Cordoba, Córdoba

S2001ODA

Hospital Italiano - Garibaldi de Rosario, Santa Fe

T1Y 6J4

Peter Lougheed Centre, Calgary

N6C 2R5

London Health Sciences Centre, London

M5G 2N2

Toronto General Hospital, Toronto

G1V 4G5

L'Hopital Laval, Sainte-Foy

Unknown

Fundacion Cardiovascular de Colombia, Floridablanca

Fundacion Clinica Shaio, Bogotá

Prince of Wales Hospital/ Division of Rheumatology, Department of Medicine & Therapeutics, Hong Kong

51 000

Clinical Hospital Center, Rijeka

00290

Helsinki University Central Hospital, Helsinki

01307

Medizinische Klinik und Poliklinik I Universitätsklinikum Carl Gustav Carus, Dresden

04103

Universtätsklinik Leipzig, Leipzig

110 002

G B Pant Hospital & Maulana Azad Medical College, New Delhi

411 004

Deenanath Mangeshkar Hospital and Research Centre, Pune

00161

Policlinico Umberto I, Cardiologia, Roma

1081 HV

VU Medisch Centrum, Dept. Pulmonology 4A 48, Amsterdam

3435 CM

St. Antonius ziekenhuis, Nieuwegein

Callao 02

Hospital Alberto Sabogal Sologuren - EsSALUD, Callao

31-202

Klinika Chorob Serca i Naczyn Instytut Kardiologii Collegium Medicum UJ, Krakow

05-400

Cardiology Otwock Priv, Otwock

41-800

III Katedra i Oddział Kliniczny Kardiologii Slaskiego Uniwersytetu Medycznego, Zabrze

022328

Institutul de boli cardiovasculare / Clinica de Cardiologie, Bucharest

050159

"Institutul de Pneumologie Marius Nasta / I. Clinica de Pneumoftiziologie", Bucharest

197 022

"State Educational Institution of High Professional Education St Petersburg State Medical", Saint Petersburg

150 003

"Municipal Health Care Institution Clinical Hospital of Emergency Care named after N.V. Soloviov", Yaroslavl

833 48

National Institute of Cardiovascular Diseases (Slovenska zdravotnicka univerzita) / Faculty of Medical Specialty Studies (Fakulta zdravotnickych speci, Bratislava

Slovak Medical University (Slovenská zdravotnícka univerzita) / Faculty of Medical Speciality Studies (Fakulta zdravotníckych špecializačných štúdií), Bratislava

221 85

University Hospital of Lund, Dept. of Cardiology, Lund

751 85

Uppsala University Hospital, Cardiology, Uppsala

NW3 2QG

Royal Free Hospital, London

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