A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

October 24, 2017

Primary Completion Date

August 28, 2024

Study Completion Date

November 30, 2025

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Macitentan

Dispersible tablet; Oral use

OTHER

Standard-of-care

Standard-of-care as per site's clinical practice which may comprise treatment with PAH non-specific treatment and/or up to two PAH-specific medications excluding macitentan and IV/SC prostanoids.

Trial Locations (86)

1096

Gottsegen Gyorgy Orszagos Kardiologiai Intezet, Budapest

1229

Makati Medical Center, Makati City

2145

Children's Hospital at Westmead, Westmead

3052

Royal Children's Hospital Melbourne - PIN, Parkville

4001

Inkosi Albert Luthuli Central Hospital, Durban

4020

Landes Frauen Und Kinderklinik Linz, Linz

Medizinische Universitat Wien, Linz

4101

Lady Cilento Children's Hospital, South Brisbane

8036

Medizinische Universität Graz, Graz

9300

University of The Free State, Bloemfontein

10032

Columbia University Medical Center - PIN, New York

10467

Montefiore Medical Center, The Bronx

13385

Hôpital de la Timone Enfants, Marseille

14001

C.H. Regional Reina Sofia, Córdoba

14080

Instituto Nacional de Cardiologia Dr. Ignacio Chavez, Mexico City

19803

University of Virginia Health System, Charlottesville

20010

Children's National Medical Center, Washington D.C.

26600

Qingdao Women and Children's Hospital, Qingdao

27710

Duke University Medical Center, Durham

27834

East Carolina University, Greenville

28009

Hospital General Universitario Gregorio Marañon, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

31059

Hôpital Des Enfants, Toulouse

31096

Rambam Medical Center - PPDS, Haifa

33604

Hôpital Haut-Lévêque - Hôpital cardiologique, Pessac

43205

Nationwide Children's Hospital, Columbus

44106

University Hospitals Cleveland Medical Center, Rainbow Babies and Childrens Hospital, Cleveland

44160

CICUM San Miguel, Guadalajara

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

46202

Riley Hospital For Children, Indianapolis

48201

Detroit Medical Center, Detroit

49000

MI Dnipropetrovsk Specialized Clin. Med. Center of Mother and Child n.a. prof. M.F. Rudnev of DRC, Dnipro

49100

Schneider Children's Medical Center of Israel - PIN, Petah Tikva

50200

Maharaj Nakorn Chiang Mai Chiang Mai University, Chiang Mai

50400

Institut Jantung Negara, Kuala Lumpur

52621

Chaim Sheba Medical Center, Ramat Gan

52763

Operadora de Hospitales Angeles SA de CV Hospital Angeles Lomas, México

53226

Childrens Hospital of Wisconsin, Milwaukee

55905

Mayo Clinic - PPDS, Rochester

59100

University Malaya Medical Centre, Kuala Lumpur

61093

Municipal Institution of Health Care Regional Children's Clinical Hospital, Kharkiv

64716

Unidad de Investigación Clínica En Medicina SC, Monterrey

75743

Groupe Hospitalier Necker Enfants Malades, Paris

80045

Childrens Hospital Colorado, Aurora

84113

Primary Children's Medical Center, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

89109

Children's Heart Center, Las Vegas

90095

UCLA Children's Heart Center, Los Angeles

100000

Hanoi Heart Hospital, Hanoi

Hanoi Medical University Hospital, Hanoi

100029

Beijing Anzhen Hospital of The Capital University of Medical Sciences, Beijing

125408

GBUZ Children's Hospital named after Bashlyaeva Z.A. Moscow, Moscow

125412

Russian National Research Medical University n.a. N.I.Pirogov, Moscow

194100

Saint Petersburg State Pediatric Medical Academy, Saint Petersburg

200062

Childrens Hospital of Shanghai, Shanghai

200127

Shanghai Children's Medical Center, Shanghai

220246

Fundacion Santa Fe de Bogota, Bogotá

450000

Bashkiria State Medical University, Ufa

625023

Clinical Hospital №1, Tyumen

630055

Novosibirsk Research Institue of Blood Circulation Pathology n.a. E.N. Meshalkin, Novosibirsk

650002

Research Institute of Complex Cardiovascular Pathology, Kemerovo

700000

Children's Hospital 1, Ho Chi Minh City

Tam Duc Hospital, Ho Chi Minh City

760042

Centro Medico Imbanaco de Cali SA, Santiago de Cali

94143-2202

UCSF Medical Center, San Francisco

02115

Boston Children's Hospital, Boston

01221-020

Irmandade Da Santa Casa de Misericórdia de São Paulo, São Paulo

H3T 1C5

Sainte Justine Hospital, Montreal

T6G 2B7

Stollery Children's Hospital, Toronto

00290

HUS Uusi lastensairaala, Helsinki

04530

Instituto Nacional de Pediatría, Mexico City

0850

Philippine Heart Center, Quezon City

60-572

Szpital Kliniczny im. Karola Jonschera Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Poznan

04-730

Instytut Pomnik - Centrum Zdrowia Dziecka, Warsaw

51-124

Wojewodzki Szpital Specjalistyczny we Wroclawiu Osrodek Badawczo-Rozwojowy, Wroclaw

2790-134

Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz, Carnaxide

3000-075

Centro Hospitalar E Universitário de Coimbra EPE, Coimbra

1169-024

Hospital Santa Marta, Lisbon

4200-319

Centro Hospitalar de Sao Joao EPE, Porto

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System - PPDS, Seoul

08035

Hospital Universitario Vall d'Hebron - PPDS, Barcelona

04050

MI Scientific Practical Medical Center for Children Cardiology and Cardiosurgery of MOH of Ukraine, Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
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Actelion

INDUSTRY

NCT02932410 - A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) | Biotech Hunter | Biotech Hunter