127
Participants
Start Date
July 7, 2020
Primary Completion Date
December 21, 2023
Study Completion Date
December 21, 2023
Macitentan
Participants will receive Macitentan film-coated tablets orally od.
Placebo
Participant will receive matching placebo tablets orally od.
Taipei Veterans General Hospital, Taipei
Chang-Gung Memorial Hospital, LinKou Branch, Taoyuan District
Kaohsiung Veterans General Hospital, Kaohsiung City
Medizinische Universitaet Wien, Vienna
Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet Felnott kardiologiai osztaly, Budapest
Military Medical Academy, Sofia
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD, Sofia
St Vincent's hospital, Darlinghurst
Ordensklinikum Linz GmbH Elisabethinen, Linz
Queensland Lung Transplant Service, Chermside
Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet és rendelő, Szeged
LKH-Univ. Klinikum Graz, Graz
Århus Universitetshospital, Skejby, Hjertemedicinsk Afdeling B, Aarhus N
National Taiwan University Hospital, Taipei
A.O.U. Città della Salute e della Scienza, Torino
University Clinical Center of Serbia, Belgrade
Thammasat Hospital, Pathum Thani
King Faisal Specialist Hospital & Research Center, Riyadh
Syracuse VA Medical Center, Syracuse
Instituto Nacional de Cardiologia Dr. Ignacio Chavez, Mexico City
University of Pittsburgh Medical Center, Pittsburgh
CNE 'Cherkasy Regional Cardiological Center of Cherkasy Regional Council', Cherkasy
Pamukkale University Medical Faculty, Denizli
Universitaetsklinikum Hamburg Eppendorf, Hamburg
Tufts Medical Center, Boston
University of Maryland, Baltimore
Institute for Pulmonary Disease of Vojvodina, Kamenitz
Eskisehir Osmangazi University Medical Faculty Hospital, Eskişehir
Fondazione IRCCS Policlinico San Matteo, Pavia
Hosp. Univ. 12 de Octubre, Madrid
Hosp. Univ. La Paz, Madrid
Hosp Virgen de La Victoria, Málaga
CHU de Brest - Hopital de la Cavale Blanche, Brest
Hosp. Costa Del Sol, Málaga
Piedmont Healthcare, Atlanta
Medizinische Hochschule Hannover Zentrum Innere Medizin Klinik für Pneumologie, Hanover
University of Florida Health Jacksonville, Gainesville
Mersin University Medical Faculty, Mersin
Istanbul University - Cerrahpasa Cardiology Institution, Istanbul
CHU de Montpellier - Arnaud de Villeneuve, Montpellier
Siyami Ersek Training and Research Hospital, Istanbul
Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi, Kartal Istanbul
Marmara University Medical Faculty, Istanbul
Ege University Medical Faculty, Izmir
Dokuz Eylul University Medical Faculty, Izmir
Universitaetsklinikum Giessen, Giessen
CHU de Grenoble Hopital Albert Michallon, Grenoble
Srinagarind Hospital, Khon Kaen University, Khon Kaen
CHU Saint Etienne Hopital Nord, Saint-Priest-en-Jarez
Cleveland Clinic, Cleveland
Hosp. Gral. Univ. de Toledo, Toledo
Municipal Non-commercial Enterprise Ternopil University Hospital of Ternopil Regional Council, Ternopil
Indiana University, Indianapolis
CE 'Dnipropetrovsk Regional Clinical Center of Cardiology and Cardiosurgery', Dnipro
Pusan National University Hospital, Busan
Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik, Kaunas
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
Operadora de Hospitales Angeles SA de CV Hospital Angeles Lomas, México
Universitatsklinikum Bonn, Bonn
CHU de Nancy - Hopital de Brabois, Vandœuvre-lès-Nancy
Fondazione Toscana Gabriele Monasterio CNR, Pisa
Centro de Investigacion Clinica Chapultepec, Morelia
Hôpital Cardiologique - Chru Lille, Lille
King Fahad Medical City, Riyadh
Northwestern University Feinberg School of Medicine, Chicago
CRI Centro Regiomontano de Investigacion SC, Nuevo León
Unidad de Investigacion Clinica en Medicina S.C. (UDICEM), Monterrey
Ospedale SS. Annunziata, Chieti
University of Kansas Medical Center, Kansas City
Universitaetsklinikum des Saarlandes, Homburg
Thoraxklinik Heidelberg, Heidelberg
Baylor Scott White - Plano, Plano
Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital', Lviv
University of Colorado Anschutz Medical Campus, Aurora
Krankenhaus Neuwittelsbach, München
Intermountain Medical Center, Murray
University of Utah Cardiovascular Center, Salt Lake City
Fundación Abood Shaio, Bogotá
University of New Mexico School of Medicine, Albuquerque
VA Sierra Nevada Health Care System, Reno
Keck School of Medicine of USC, Los Angeles
University of California San Diego Medical Center, La Jolla
Hopital Bicetre Aphp Hopitaux Universitaires Paris Sud, Le Kremlin-Bicêtre
Legacy Hospital, Portland
Beijing Chaoyang Hospital, Beijing
Beijing Anzhen Hospital, Beijing
China Japan Friendship Hospital, Beijing
Beijing Shijitan Hospital, Beijing
The General Hospital of Northern Theater Command, Shenyang
National University Heart Centre, Singapore, Singapore
Moscow City Clinical Hospital No.51, Moscow
National Medical Research Center of Cardiology of MoH of Russian Federation, Moscow
National Heart Centre (NHC) Singapore, Singapore
National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation, Saint Petersburg
Huashan Hospital of Fudan University, Shanghai
Shanghai Pulmonary Hospital, Shanghai
Zhongda Hospital Southeast University, Nanjing
The Affiliated Hospital of Medical College Qingdao University, Qingdao
Tianjin Medical University General Hospital, Tianjin
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
Volgograd Regional Clinical Cardiology Center, Volgograd
The First Affiliated Hospital of Chongqing Medical University, Chongqing
State Autonomous HealthCare Institution 'Interregional Clinical Diagnostic Center', Kazan'
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
Spitalul Clinic Judetean de Urgenta, Tg. Mures
Centro Cardiovascular Colombiano Clínica Santa María, Medellín
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
Clínica Imbanaco S.A.S., Santiago de Cali
Fundacion Neumologica Colombiana, Bogotá
The Chaim Sheba Medical Center, Tel Litwinsky
Tel Aviv Medical Center, Tel Aviv
UC Davis Medical Center, Sacramento
Yale University School Of Medicine, New Haven
Massachusetts General Hospital, Boston
University of Nebraska Medical Center, Omaha
University of Wisconsin Hospital and Clinics, Madison
Nexo Salud Investigacion Clinica, Buenos Aires
Sanatorio de la Trinidad Mitre, Buenos Aires
Sanatorio Guemes, C.a.b.a.
University Of Calgary - Peter Lougheed Centre, Calgary
University of Alberta Hospital, Edmonton
University Health Network - Toronto General Hospital, Toronto
Zhongshan Hospital Fudan University, Shanghai
Hopital Larrey CHU de Toulouse, Toulouse
General University Hospital II.department of Internal Medicine-cardiology and angiology, Prague
Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden, Dresden
Universitatsklinikum Jena, Jena
Policlinico Gemelli Universita Cattolica, Roma
The University of Tokyo Hospital, Bunkyō City
Kyushu University Hospital, Fukuoka
Kure Kyosai Hospital, Hiroshima
St Marianna University Hospital, Kanagawa
Kobe University Hospital, Kobe
University Hospital Kyoto Prefectural University of Medicine, Kyoto
Kyoto University Hospital, Kyoto
Shinshu University Hospital, Matsumoto
Toho University Medical Center, Ohashi Hospital, Meguro-ku
Kyorin University Hospital, Mitaka
Nagoya University Hospital, Nagoya
National Hospital Organization Okayama Medical Center, Okayama
Hokkaido University Hospital, Sapporo
National Cerebral and Cardiovascular Center, Suita-Shi
Juntendo University Hospital, Tokyo
University of Tsukuba Hospital, Tsukuba
Vilnius University Hospital Santariskiu Klinikos, Vilnius
Krakowski Szpital Specjalistyczny im Jana Pawla II, Krakow
Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego PZOZ, Lublin
Europejskie Centrum Zdrowia Otwock Sp z o o, Otwock
Uls Almada Seixal - Hosp. Garcia de Orta, Almada
Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu, Bucharest
Narodny ustav srdcovych a cievnych chorob, Bratislava
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Marys Hospital, Seoul
Hosp Clinic de Barcelona, Barcelona
Adana City Hospital, Adana
Cukurova University Medical Faculty, Adana
Hacettepe University Medical Faculty, Ankara
Ankara Bilkent Sehir Hastanesi, Ankara
SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine, Kyiv
State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams Ukraine, Kyiv
Papworth Hospital NHS Trust, Cambridge
National Waiting Times Centre Board Golden Jubilee National Hospital, Glasgow
Royal Free Hospital, London
Hammersmith Hospital, London
Freeman Hospital, Newcastle upon Tyne
Sheffield Teaching Hospitals NHS Foundation Trust Royal Hallamshire Hospital, Sheffield
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