935
Participants
Start Date
June 30, 2020
Primary Completion Date
October 7, 2025
Study Completion Date
February 20, 2029
Macitentan 10 mg
Participants will receive macitentan 10 mg film-coated tablets orally.
Macitentan 37.5 mg
Participants will receive macitentan 37.5 mg film-coated tablets orally.
Macitentan 75 mg
Participants will receive macitentan 75 mg film-coated tablets orally.
Placebo
Participants will receive matching placebo film-coated tablets orally.
Taipei Veterans General Hospital, Taipei
Oslo University Hospital, Oslo
National Cheng Kung University Hospital, Tainan City
ULB Hôpital Erasme, Brussels
Semmelweis Egyetem,Pulmonológiai Klinika, Budapest
Medical University Vienna, Vienna
Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet Felnott kardiologiai osztaly, Budapest
Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead, Sofia
Akershus Universitetssykehus, Nordbyhagen
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD, Sofia
Dr Kalla, Lenasia
Instituto Medico de La Fundacion Estudios Clinicos, Rosario
St Vincent's hospital, Darlinghurst
Royal Prince Alfred Hospital, Camperdown
Westmead Hospital, Westmead
UZ Leuven, Leuven
Seoul National University Hospital, Seoul
Ordensklinikum Linz GmbH Elisabethinen, Linz
The Prince Charles Hospital, Chermside
Flinders Medical Centre, Bedford Park
Fiona Stanley Hospital, Murdoch
Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet és rendelő, Szeged
Royal Hobart Hospital, Hobart
Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar, Pécs
Hosp. Del Mar, Barcelona
LKH-Univ. Klinikum Graz, Graz
Århus Universitetshospital, Skejby, Hjertemedicinsk Afdeling B, Aarhus
National Taiwan University Hospital, Taipei
Mount Sinai, New York
Columbia University, New York
Phramongkutklao Hospital and Medical College, Bangkok
Ramathibodi Hospital Mahidol University, Bangkok
Mackay Memorial Hospital, Taipei
Siriraj Hospital Mahidol University, Bangkok
Hospital Pulau Pinang, George Town
University Clinical Center of Serbia, Belgrade
Winthrop University Hospital, Mineola
Alexandra General Hospital of Athens, Athens
King Faisal Specialist Hospital & Research Center, Riyadh
Stony Brook University Medical Center, Stony Brook
Aphm - Hopital Nord, Marseille
Instituto Nacional de Cardiologia Dr. Ignacio Chavez, Mexico City
Allegheny General Hospital of Research, Pittsburgh
Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
CNE 'Cherkasy Regional Cardiological Center of Cherkasy Regional Council', Cherkassy
Communal Noncommercial Enterprise Cherkasy Regional Hospital of Cherkasy Regional Council, Cherkasy
Lankenau Medical Center, Wynnewood
Pamukkale University Medical Faculty, Denizli
ASST Grande Ospedale Metropolitano Niguarda, Milan
Institute for Pulmonary Disease of Vojvodina, Kamenitz
Fondazione IRCCS Policlinico San Matteo, Pavia
Hosp. Univ. 12 de Octubre, Madrid
Hosp. Univ. La Paz, Madrid
Hosp. Univ. Pta. de Hierro Majadahonda, Madrid
CHU de Brest - Hopital de la Cavale Blanche, Brest
Hosp. Costa Del Sol, Málaga
AnMed Health, Anderson
Piedmont Healthcare, Atlanta
Northside Hospital, Atlanta
Medizinische Hochschule Hannover, Hanover
Ruhr Universitat Bochum Diabeteszentrum, Bad Oeynhausen
Mersin University Medical Faculty, Mersin
Carmel Medical Center, Haifa
Siyami Ersek Training and Research Hospital, Istanbul
Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi, Kartal Istanbul
Marmara University Medical Faculty, Istanbul
Ege University Medical Faculty, Izmir
Tepecik Training and Research Hospital, Izmir
Dokuz Eylul University Medical Faculty, Izmir
Hosp Clinico Univ de Salamanca, Salamanca
Srinagarind Hospital, Khon Kaen University, Khon Kaen
Norton Pulmonary Specialists, Louisville
AOU Di Modena Policlinico Di Modena, Modena
University Hospital Of Larissa, Larissa
CHU Saint Etienne Hopital Nord, Saint-Priest-en-Jarez
Hospital Serdang, Kajang
Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez, Guadalajara
Lindner Clinical Trial Center/Christ Hospital, Cincinnati
Municipal Non-commercial Enterprise Ternopil University Hospital of Ternopil Regional Council, Ternopil
Indiana University, Indianapolis
St. Vincent Medical Group, Inc., Indianapolis
MI 'Dnipropetrovsk Regional Clinical Center of Cardiology and Cardiac Surgery', Dnipro
Maharaj Nakorn Chiang Mai hospital Faculty of Medicine, Chiang Mai
Institut Jantung Negara (National Heart Institute), Kuala Lumpur
University Of Iowa - Hospitals & Clinics, Iowa City
Operadora de Hospitales Angeles SA de CV Hospital Angeles Lomas, México
Troy Beaumont, Troy
Medical College Of Wisconsin, Milwaukee
University of Wisconsin Hospital and Clinics, Madison
Ahepa University General Hospital of Thessaloniki, Thessaloniki
Fondazione Toscana Gabriele Monasterio CNR, Pisa
Centro de Investigacion Clinica Chapultepec, Morelia
King Fahad Medical City, Riyadh
Advocate Christ Medical Center, Oak Lawn
CNE' City Clinical Hospital #8' of Kharkiv City Council, Kharkiv
Saint Louis University Academic Pavillion, St Louis
Govindaswamy Kuppuswamy Naidu Memorial Hospital, Coimbatore
Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey
Unidad de Investigacion Clinica en Medicina S.C. (UDICEM), Monterrey
Yitzhak Shamir Medical Center, Ẕerifin
Integris Baptist Office, Oklahoma City
Baylor Scott White - Plano, Plano
UT Southwestern Medical Center, Dallas
Kaplan Medical Center, Rehovot
Baylor College of Medicine (BCM) - Baylor Heart Clinic, Houston
Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital', Lviv
National Jewish Health, Denver
Uniwersyteckie Centrum Kliniczne, Gdansk
Medizinische Klinik und Poliklinik V Klinikum Grosshadern der LMU, München
Mayo Clinic, Phoenix
Arizona Pulmonary Specialists, Ltd, Scottsdale
Reno Heart Institute, Reno
USC Keck, Los Angeles
Songklanagarind hospital, Songkhla
Shaare Zedek Medical Center, Jerusalem
Scripps Memorial Hospital, La Jolla
Universitaetsklinikum Regensburg, Regensburg
Jeffrey S. Sager, MD Medical Corporation, Santa Barbara
Hopital Bicetre Aphp Hopitaux Universitaires Paris Sud, Le Kremlin-Bicêtre
Sarawak Heart Center, Kota Samarahan
Beijing Chaoyang Hospital, Beijing
Beijing Anzhen Hospital, Beijing
Peking Union Medical College Hospital, Beijing
The General Hospital of Northern Theater Command, Shenyang
GB Pant Institute of Post Graduate Medical Education & Research, New Delhi
Shengjing Hospital Of China Medical University, Shenyang
Sir Ganga Ram Hospital, New Delhi
National University Heart Centre, Singapore, Singapore
Moscow City Clinical Hospital No.51, Moscow
National Medical Research Center of Cardiology of MoH of Russian Federation, Moscow
National Heart Centre (NHC) Singapore, Singapore
National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation, Saint Petersburg
Shanghai Pulmonary Hospital, Shanghai
Renji Hospital, Shanghai
The Republican Scientific-Practical Center ''Cardiology'', Minsk
Minsk Regional Clinical Hospital, Minsk
Tianjin Medical University General Hospital, Tianjin
NHL Medical College (SVP Hospital IMSR), Ahmedabad
Cims Hospital, Ahmedabad
B.D. Mehta Mahavir Heart Institute, Surat
Volgograd Regional Clinical Cardiology Center, Volgograd
The First Affiliated Hospital of Chongqing Medical University, Chongqing
The Second Xiangya Hospital of Central South Hospital, Changsha
State Autonomous HealthCare Institution 'Interregional Clinical Diagnostic Center', Kazan'
Samara Regional Clinical Cardiological Dispensary, Samara
Chelyabinsk Regional Clinical Hospital, Chelyabinsk
Renova Century Hospitals, Hyderabad
Care Hospitals, Hyderbad
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
Narayana Hrudayalaya Limited, Bangalore
SRM Medical College Hospital & Research Centre, Chengalpetu
Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry
West China Hospital Sichuan University, Chengdu
State Autonomous Healthcare Institution of Tyumen Region 'Scientific and Practical Medical Center', Tyumen
Scientific and Research Institution of Cardiovascular Diseases Complex Problems, Kemerovo
Altay Regional Cardiological Dispensary, Barnaul
Centro Cardiovascular Colombiano Clínica Santa María, Medellín
Cho Ray Hospital, Ho Chi Minh City
Tam Anh Hospital, Ho Chi Minh City
Tam Duc Heart Hospital, Ho Chi Minh City
University Medical Center Ho Chi Minh city, Ho Chi Minh City
Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
HealthWorld Hospitals, Durgapur
Clínica Imbanaco S.A.S., Santiago de Cali
Fundacion Neumologica Colombiana, Bogotá
The Chaim Sheba Medical Center, Tel Litwinsky
Fundacion Cardiovascular de Colombia, Bucaramanga - Piedecuesta - Valle de Menzuli
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
Cleveland Clinic, Weston
Louisiana State University, New Orleans
University of Michigan, Ann Arbor
Washington University School Of Medicine, St Louis
University of Nebraska Medical Center, Omaha
Duke, Durham
The Oregon Clinic, Portland
Oregon Pulmonary Clinic, Portland
Oregon Health And Science University, Portland
University of Pennsylvania, Philadelphia
San Antonio Methodist TX Transplant Physicians Group, San Antonio
The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington
Sanatorio de la Trinidad Mitre, Buenos Aires
Sanatorio Guemes, C.a.b.a.
Hospital Italiano de Buenos Aires, Caba
Sanatorio Ramon Cereijo, Caba
Centro Médico Dra. De Salvo, Caba
Instituto de Cardiologia de Corrientes, Corrientes
Instituto Cardiovascular de Rosario, Rosario
Universidade Federal De Minas Gerais - Hospital das Clínicas, Belo Horizonte
Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa, Belo Horizonte
Empresa Brasileira de Servicos Hospitalares-EBSERH-Hospital Universitario de Brasilia, Brasília
Sociedade Hospitalar Angelina Caron - Hospital Angelina Caron, Campina Grande do Sul
Ceti - Centro de Estudos Em Terapias Inovadoras, Curitiba
Ynova Pesquisa Clinica, Florianópolis
Universidade Federal de Goias - Hospital das Clinicas da UFG, Goiânia
Hospital das Clinicas de Porto Alegre, Porto Alegre
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre
Instituto de Medicina Integral Professor Fernando Figueira, Recife
Fundacao do ABC Centro Universitario FMABC, Santo André
Secretaria de Estado da Saude Instituto Dante Pazzanese de Cardiologia, São Paulo
Hospital Das Clinicas Da Faculdade De Medicina Da USP, São Paulo
St. Joseph's Health Centre, Hamilton
University of Ottawa Heart Institute, Ottawa
University Health Network - Toronto General Hospital, Toronto
Jewish General Hospital, Montreal
Zhongshan Hospital Fudan University, Shanghai
Hôpital Côte de Nacre, Caen
CHRU de Lille Hopital Claude Huriez, Lille
Hopital Larrey CHU de Toulouse, Toulouse
Milpark Hospital, Johannesburg
Hanoi Medical University Hospital, Hanoi
Hospital Universidad del Norte, Soledad
General University Hospital II.department of Internal Medicine-cardiology and angiology, Prague
Centre Hospitalier Universitaire - de Nice - Hopital Pasteur, Nice
University Hospital of Alexandroupolis, Alexandroupoli
Ospedale San Francesco, Nuoro
Policlinico Gemelli Universita Cattolica, Roma
The University of Tokyo Hospital, Bunkyō City
Kyushu University Hospital, Fukuoka
Kure Kyosai Hospital, Hiroshima
Kagoshima University Hospital, Kagoshima
St Marianna University Hospital, Kanagawa
Kanazawa University Hospital, Kanazawa
Kobe University Hospital, Kobe
Kurume University Hospital, Kurume
University Hospital Kyoto Prefectural University of Medicine, Kyoto
Kyoto University Hospital, Kyoto
Shinshu University Hospital, Matsumoto
Nagasaki University Hospital, Nagasaki
Nagoya University Hospital, Nagoya
Nagoya City University Hospital, Nagoya
Niigata University Medical And Dental Hospital, Niigata
Okayama University Hospital, Okayama
National Hospital Organization Okayama Medical Center, Okayama
Sapporo Medical University Hospital, Sapporo
Hokkaido University Hospital, Sapporo
National Cerebral and Cardiovascular Center, Suita-Shi
Juntendo University Hospital, Tokyo
Fujita Health University Hospital, Toyoake
University of Tsukuba Hospital, Tsukuba
VUMC Amsterdam, Amsterdam
St. Antonius Ziekenhuis Nieuwegein, Nieuwegein
Radboud Umcn, Nijmegen
Erasmus MC, Rotterdam
Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii, Bydgoszcz
SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im Prof Leszka Gieca, Katowice
Krakowski Szpital Specjalityczny im Jana Pawla II Oddzial Kliniczny Chorob Serca i Naczyn, Krakow
Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie, Szczecin
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji, Warsaw
Wojewodzki Szpital Specjalistyczny we Wroclawiu Osrodek Badawczo Rozwojowy, Wroclaw
Uls Coimbra - Hosp. Univ. Coimbra, Coimbra
Uls Sao Jose - Hosp. Santa Marta, Lisbon
Uls Santa Maria - Hosp. Pulido Valente, Lisbon
Narodny ustav srdcovych a cievnych chorob, Bratislava
The Eastern Slovakia Institute of Cardiovascular Diseases, Košice
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hosp Univ Vall D Hebron, Barcelona
Sahlgrenska Universitetsjukhuset, Gothenburg
Skanes universitetssjukhus, Lund
Adana City Hospital, Adana
Cukurova University Medical Faculty, Adana
Ankara Etlik Speciality Hospital, Ankara
Hacettepe University Medical Faculty, Ankara
Gazi University Medical Faculty, Ankara
Ankara Bilkent Sehir Hastanesi, Ankara
Akdeniz University Medical Faculty, Antalya
SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine, Kyiv
State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams Ukraine, Kyiv
Royal Free Hospital, London
Freeman Hospital, Newcastle upon Tyne
Sheffield Teaching Hospitals NHS Foundation Trust Royal Hallamshire Hospital, Sheffield
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