Biologics
Total Trials
106
As Lead Sponsor
76
As Collaborator
30
Total Enrollment
13,641
NCT00070616
Pharmacokinetic Study of Palifermin in Subjects Receiving Radiation Therapy and Chemotherapy Followed by Blood Stem Cell Support
Phase: Phase 1
Role: Lead Sponsor
Start: Dec 31, 2001
Completion: Mar 31, 2005
NCT00094861
Study to Evaluate Palifermin in the Reduction of Dysphagia in Patients With Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Phase: Phase 2
Start: Jan 31, 2005
Completion: Jan 31, 2014
NCT00109031
Palifermin for the Reduction of Oral Mucositis in Single-dose Evaluation (PROMISE)
Phase: Phase 3
Completion: Dec 31, 2010
NCT00626639
A Study of Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer Receiving Postoperative Radiotherapy and Concurrent Chemotherapy
Phase: Phase 1/2
Start: Jul 31, 2005
Completion: Jul 31, 2015
NCT00101582
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
Start: Aug 31, 2005
Completion: Aug 31, 2016
NCT00189488
Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation
Start: Dec 31, 2005
Completion: Aug 31, 2013
NCT00361348
Palifermin DDI (Drug Drug Interaction)
Completion: Jul 31, 2006
NCT00352703
PROMPT - Palifermin in Reduction of Oral Mucositis in PBSC Transplantation
Phase: Phase 4
Start: Apr 30, 2006
Completion: May 31, 2007
NCT00460421
A Phase 1 Dose-escalation Study to Evaluate the Safety and Pharmacokinetics (PK) of Palifermin in Subjects With Acute Leukemias Undergoing HSCT
Start: Aug 31, 2006
Completion: May 31, 2011
NCT00434161
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Multiple Myeloma
Start: Dec 31, 2006
Completion: May 31, 2012
NCT00452777
Efficacy and Tolerability of Novel A2A Agonist in Treatment of Diabetic Neuropathic Pain
Start: May 31, 2007
Completion: Jan 31, 2008
NCT00540332
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Locally Advanced Head and Neck Cancer Receiving Postoperative Radiotherapy
Start: Oct 31, 2007
Completion: Sep 30, 2008
NCT00659243
Efficacy and Safety of Bile Salt Stimulated Lipase (BSSL) as Replacement Therapy in Pasteurized Breast Milk for Preterm Infants
Start: Mar 31, 2008
Completion: Feb 28, 2010
NCT00658905
Efficacy and Safety of Bile Salt Stimulated Lipase (BSSL) as Replacement Therapy in Infant Formula for Preterm Infants
Start: Apr 30, 2008
Completion: May 31, 2009
NCT00716716
Phase I/IIa Study of FIXFc in Hemophilia B Patients
Role: Collaborator
Completion: Oct 31, 2009
NCT00718692
Open Label Trial on the Safety and Efficacy of Sym001 in the Treatment of Immune Thrombocytopenic Purpura (ITP)
Start: Jul 31, 2008
Completion: Oct 31, 2011
NCT00743483
Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency
Start: Aug 31, 2008
Completion: Jun 30, 2009
NCT01027364
Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia B
Start: Dec 31, 2009
Completion: Jul 31, 2012
NCT01163097
Study to Characterize the Effect of Heparin on Palifermin Activity
Start: Jul 31, 2010
Completion: Jan 31, 2011
NCT02037347
Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
Start: Oct 31, 2010
Completion: Dec 31, 2014
NCT01181128
Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Subjects With Severe Hemophilia A
Start: Nov 30, 2010
Completion: Aug 31, 2012
NCT01306123
Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration
Start: Feb 28, 2011
NCT01413581
Comparison of rhBSSL With Placebo When Added to Infant Formula or Pasteurized Breast Milk During 4 Weeks of Treatment in Preterm Infants
Start: May 31, 2011
Completion: Aug 31, 2014
NCT01459562
First in Human Study of an Anti-IFN Gamma Monoclonal Antibody in Healthy Volunteers
Start: Sep 30, 2011
Completion: Jan 31, 2013
NCT01440946
Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB029, in Previously Treated Pediatric Participants With Hemophilia B
Start: Jun 30, 2012
Completion: Nov 30, 2014
NCT01682538
Bioequivalence of Orfadin Suspension Compared to Orfadin Capsules, and the Effect of Food on the Bioavailability of the Suspension
Start: Aug 31, 2012
Completion: Oct 31, 2012
NCT01734889
Taste and Palatability of Orfadin Suspension
Start: Oct 31, 2012
Completion: Mar 31, 2013
NCT02915094
Kineret in the Treatment of Rheumatoid Arthritis
Phase: N/A
Completion: Jan 31, 2016
NCT01458106
Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia A
Start: Nov 30, 2012
Completion: Dec 31, 2013
NCT01746849
Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation
Start: Dec 31, 2012
Completion: Dec 31, 2025
NCT01857362
Bioequivalence of Orfadin 20 mg Compared to Orfadin 10 mg Capsules.
Start: May 31, 2013
Completion: Jun 30, 2013
NCT01818492
Study to Investigate Safety, Efficacy of an Anti-IFNγ mAb in Children With Primary Haemophagocytic Lymphohistiocytosis
Phase: Phase 2/3
Start: Jul 31, 2013
Completion: Jan 31, 2019
NCT02320084
Long Term Safety Study of Orfadin Treatment in HT-1 Patients in Standard Clinical Care
Start: Sep 30, 2013
Completion: Sep 30, 2019
NCT02083666
Safety and Tolerability of SOBI002 in Healthy Volunteers Following Single and Repeated Administration
Start: Dec 31, 2013
Completion: Feb 28, 2015
NCT02049099
A Non-interventional Retrospective Study of the Current Treatment Practice in European Haemophilia Care
Start: Mar 31, 2014
Completion: Sep 30, 2015
NCT02069899
A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody
Start: Aug 4, 2014
Completion: May 18, 2021
NCT02234310
Study to Determine the Safety and Efficacy of rFIXFc in Previously Untreated Males With Severe Hemophilia B
Start: Nov 13, 2014
Completion: Aug 20, 2019
NCT02323529
Efficacy and Safety of Once Daily Dosing Compared to Twice Daily Dosing of Nitisinone in HT-1
Start: Dec 31, 2014
NCT02234323
An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Previously Untreated Males With Severe Hemophilia A
Start: Jan 12, 2015
Completion: Sep 23, 2019
NCT02326376
Kineret CAPS Post Authorisation Study
Start: Apr 24, 2015
Completion: Sep 12, 2019
NCT02392156
Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes
Start: Jul 31, 2015
Completion: Dec 31, 2015
NCT02502409
Natural History Study of Factor IX Treatment and Complications
Completion: Dec 31, 2021
NCT02502149
Pharmacokinetics and Safety of rFVIIIFc Manufactured at 15,000 L (15K) Scale
Start: Aug 31, 2015
Completion: Jun 30, 2017
NCT02390596
Anakinra and Kawasaki Disease
Start: Feb 5, 2016
Completion: Feb 18, 2019
NCT05512676
Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum
Start: Mar 7, 2016
Completion: Aug 1, 2022
NCT03259230
Evaluation of IFNγ and Inflammatory Mediators in Patients With Malignancy-Associated Hemophagocytic Lymphohistiocytosis
Start: Oct 13, 2016
Completion: Jan 29, 2020
NCT06047210
Evaluation of IFNγ and Inflammatory Mediators in Patients With Hemophagocytic Lymphohistiocytosis
Start: Dec 14, 2016
Completion: Oct 30, 2019
NCT02976753
Prospective, Non-interventional Study to Evaluate the Effectiveness of Elocta Compared to Conventional Factor Products
Start: Dec 31, 2016
Completion: Nov 3, 2021
NCT03002974
A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Acute Gouty Arthritis
Completion: Aug 31, 2019
NCT03103568
A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
Start: Mar 28, 2017
Completion: Jul 24, 2017
NCT03055611
A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or B
Start: May 9, 2017
Completion: Apr 19, 2022
NCT03165734
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
Start: Jun 26, 2017
Completion: Jul 30, 2027
NCT03103542
Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies
Start: Aug 29, 2017
Completion: Aug 31, 2020
NCT03265132
A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
Start: Sep 26, 2017
Completion: May 23, 2019
NCT03093480
A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study)
Start: Dec 8, 2017
Completion: Feb 16, 2021
NCT03311854
A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH)
Start: Feb 20, 2018
Completion: May 19, 2020
NCT03423186
A Study to Assess the Safety and Tolerability of SOBI003 in Pediatric MPS IIIA Patients
Start: Jun 19, 2018
Completion: Oct 25, 2019
NCT03655340
A Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B in France
Start: Sep 12, 2018
Completion: Mar 16, 2022
NCT03276130
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and B
Start: Oct 30, 2018
Completion: Jan 30, 2020
NCT03951103
rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia A
Start: Nov 7, 2018
Completion: Sep 30, 2022
NCT03587701
Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
Start: Jan 3, 2019
NCT03811028
A Study to Assess the Safety, Tolerability, and Efficacy of Long-term SOBI003 Treatment in Pediatric MPS IIIA Patients
Start: Jan 19, 2019
Completion: May 7, 2021
NCT03312751
Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis
Start: Feb 6, 2019
Completion: Sep 14, 2022
NCT03932344
Long-term Safety Study of Kineret® in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)
Start: Apr 10, 2019
NCT03901755
An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B
Start: Sep 12, 2019
Completion: Mar 12, 2024
NCT04133883
Impact on French Physician's Haemophilia Treatment Management Decision Based on Systematic Joint Examination
Start: Jan 13, 2020
Completion: Jul 13, 2022
NCT04018755
Open-label Study of Anakinra in MPS III
Start: Jan 30, 2020
Completion: Mar 8, 2023
NCT04293523
A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health
Start: Mar 30, 2020
Completion: Apr 30, 2026
NCT04324021
Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection.
Start: Apr 2, 2020
Completion: Nov 13, 2020
NCT04364009
Anakinra for COVID-19 Respiratory Symptoms
Start: Apr 27, 2020
Completion: Nov 3, 2020
NCT03985423
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Emapalumab in Adult Patients With HLH
Start: Jun 2, 2020
Completion: Jun 29, 2021
NCT04513366
A Study of SEL-212 in Patients With Gout Refractory to Conventional Therapy
Start: Aug 18, 2020
Completion: Dec 1, 2022
NCT04494061
A Clinical Study to Investigate Interferon Gamma (IFNɣ) Signature in Patients Post HSCT and in Patients With Impaired HSC Proliferation Pre-transplant
Start: Nov 16, 2020
Completion: Aug 31, 2022
NCT04596540
A Study of SEL-212 in Patients With Gout Refractory to Conventional Therapy II
Start: Nov 30, 2020
Completion: Jan 12, 2023
NCT04765553
A Study to Evaluate Emapalumab in Japanese Healthy Volunteers.
Start: Jan 14, 2021
Completion: Jul 25, 2021
NCT04550988
Sonography and Haemophilia
Start: Feb 8, 2021
Completion: Dec 31, 2022
NCT04691765
Anakinra in Previously Untreated Chronic Lymphocytic Leukemia Patients
Start: May 1, 2021
NCT04731701
Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)
Start: May 5, 2021
Completion: Jul 19, 2022
NCT04731298
Study to Investigate the Pharmacokinetics, Pharmacodynamics and Assess the Efficacy and Safety to Support Dose Selection of Emapalumab in Pre-empting Graft Failure in Patients at High Risk After HSCT.
Start: May 25, 2021
Completion: Apr 21, 2022
NCT05152238
ITP Registry and Accompanying Biospecimen Collection
Start: Nov 29, 2021
Completion: Apr 30, 2027
NCT05001737
Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE
Start: Dec 15, 2021
Completion: Jun 4, 2025
NCT04359784
Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy
Start: Dec 27, 2021
Completion: Dec 23, 2024
NCT04603742
Anakinra, COVID-19, Cytokine Storm
Start: Dec 31, 2021
NCT05148299
Evaluate the PK Efficacy Safety and Tolerability of Pegcetacoplan in Patients With Thrombotic Microangiopathy
Start: Feb 1, 2022
Completion: Nov 25, 2024
NCT04943042
An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet® in Patients With ITP
Start: Feb 22, 2022
Completion: Jun 10, 2025
NCT05814159
A Study of Anakinra in Japanese Patients With Still's Disease (SJIA and AOSD)
Start: Aug 24, 2022
Completion: Jun 24, 2026
NCT05096403
A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With Cold Agglutinin Disease (CAD)
Start: Oct 20, 2022
Completion: Sep 11, 2024
NCT05744063
A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients
Start: Feb 3, 2023
Completion: Aug 8, 2025
NCT05776472
A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Start: Jun 26, 2023
Completion: Aug 15, 2029
NCT05817812
A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa
Start: Jul 31, 2023
Completion: Jun 12, 2026
NCT05856266
An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog Alfa
Start: Aug 24, 2023
Completion: Dec 6, 2023
NCT06405152
Assessment of Macrophage Activation syndromE in STill's Disease
Start: Sep 27, 2023
Completion: Sep 26, 2024
NCT04656184
A Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment
Start: Oct 20, 2023
Completion: Mar 31, 2027
NCT05772546
Avatrombopag vs. Placebo for CIT in GI Malignancies
Start: Nov 1, 2023
Completion: Jul 31, 2026
NCT06352216
Prevalence of Synovitis in Patients With Haemophilia A
Start: Apr 15, 2024
NCT06550141
Emapalumab Prevention of CAR-T Cell Associated Toxicities
Start: Sep 18, 2024
Completion: Aug 1, 2027
NCT06752850
A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis
Start: Dec 19, 2024
Completion: Dec 31, 2026
NCT06538181
Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome
Start: Feb 13, 2025
Completion: Feb 28, 2029
NCT06579144
Pharmacokinetic Comparison of Efanesoctocog Alfa vs Other EHL-rFVIII Products in Participants With Severe Haemophilia A
Start: Feb 24, 2025
Completion: Oct 28, 2025
NCT06716814
Study to Provide Continued Access to Treatment for Patients Completing a Previous Trial With Efanesoctocog Alfa
Start: Mar 6, 2025
NCT06940830
Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa
Start: May 21, 2025
Completion: Dec 31, 2028
NCT06782373
A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)
Start: May 28, 2025
Completion: Aug 31, 2027
NCT06992505
Assessment of Macrophage Activation syndromE in STill's Disease in Italy
Start: Jun 6, 2025
Completion: Sep 30, 2025
NCT06666335
A Study to Evaluate Efficacy and Safety of Anakinra in Chinese Patients With Colchicine-resistent FMF
Start: Sep 1, 2025
Completion: Nov 30, 2027
NCT06227429
A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 Patients
Start: Sep 30, 2025
Completion: Jun 30, 2027
NCT07148947
Pacritinib With Standard of Care Azacitidine or Decitabine as a Bridge to Allogeneic Hematopoietic Stem Cell Transplant for Patients With Accelerated and Blast Phase Myeloproliferative Neoplasms
Start: Feb 1, 2026
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