399
Participants
Start Date
June 26, 2017
Primary Completion Date
December 31, 2026
Study Completion Date
July 30, 2027
Pacritinib
Oral administration. Supplied in capsules containing 100 mg (as the free base) in red cap/gray body size 0 opaque hard gelatin capsules. The inactive ingredients are microcrystalline cellulose, magnesium stearate, and polyethylene glycol 8000. Each capsule contains 146 mg of pacritinib citrate, which is equivalent to 100 mg pacritinib free base
Physician's Choice medications
Physician's Choice medications will be selected and administered according to the investigator's judgement. Investigators can select individual P/C agents but cannot combine agents or give them sequentially.
RECRUITING
Severance Hospital, Seoul
COMPLETED
Columbia University Medical Center, New York
COMPLETED
Weill Cornell Medical College, New York
COMPLETED
Icahn School of Medicine at Mount Sinai, New York
COMPLETED
Memorial Sloan -Kettering Cancer Center, New York
COMPLETED
University of Rochester, Rochester
COMPLETED
UPMC Hillman Cancer Center, Pittsburgh
COMPLETED
Georgetown University Hospital, Washington D.C.
COMPLETED
George Washington University-Medical Faculty Associates, Washington D.C.
COMPLETED
American Oncology Partners of Maryland, PA, Bethesda
COMPLETED
Regional Cancer Care Associates LLC - CCBD Division, Bethesda
COMPLETED
Maryland Oncology Hematology, PA- Columbia, Columbia
COMPLETED
Saint Agnes Hospital, Baltimore
COMPLETED
Johns Hopkins University, Baltimore
COMPLETED
Duke University Hospital, Durham
RECRUITING
CHU de Nimes - Hopital Universitaire Caremeau, Nîmes
COMPLETED
Cleveland Clinic Florida, Weston
RECRUITING
CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque, Pessac
COMPLETED
University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center, Birmingham
COMPLETED
The Sarah Cannon Research Institute-Tennessee Oncology, Nashville
COMPLETED
The James Cancer Hospital and Solove Research Institute, Columbus
COMPLETED
Cleveland Clinic, Cleveland
COMPLETED
Michigan Medicine Hematology Clinic-Rogel Cancer Center, Ann Arbor
COMPLETED
Cancer and Hematology Centers of Western Michigan, Grand Rapids
COMPLETED
Northwestern Memorial Hospital, Chicago
COMPLETED
Rush University Medical Center, Chicago
COMPLETED
The University of Chicago Medical Center, Chicago
COMPLETED
Washington University School of Medicine-Siteman Cancer Center, St Louis
COMPLETED
University of Kansas Cancer Center and Medical Pavilion, Westwood
COMPLETED
Ochsner Medical Center, New Orleans
COMPLETED
The University of Texas MD Anderson Cancer Center, Houston
COMPLETED
Mays Cancer Center, San Antonio
COMPLETED
Texas Oncology- San Antonio, San Antonio
COMPLETED
University of Colorado Cancer Center, Aurora
SUSPENDED
CHU Hôpital Amiens Sud, Amiens
COMPLETED
Rocky Mountain Cancer Centers (US Oncology/McKesson), Boulder
COMPLETED
University of Utah - Huntsman Cancer Institute, Salt Lake City
COMPLETED
Mayo Clinic Hospital, Phoenix
COMPLETED
Comprehensive Cancer Centers of Nevada- Twain Office, Las Vegas
COMPLETED
USC Norris Comprehensive Cancer Center, Los Angeles
COMPLETED
UCLA David Geffen School of Medicine, Los Angeles
COMPLETED
City of Hope, Duarte
COMPLETED
Fred Hutchinson Cancer Research Center, Seattle
COMPLETED
Yale School of Medicine, New Haven
COMPLETED
Hackensack University Medical Center, Hackensack
COMPLETED
Oregon Health and Science University, Portland
RECRUITING
Westmead Hospital, Sydney
RECRUITING
Alfred Hospital, Malignant Hematology and Stem Cell Transplantation Service, Melbourne
RECRUITING
The Perth Blood Institute, Perth
COMPLETED
Grodno University Hospital, Grodno
RECRUITING
Republican Research Center for Radiation Medicine and Human Ecology, Homyel
RECRUITING
Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology, Minsk
RECRUITING
University Clinical Centre of the Republic of Srpska, Banja Luka
RECRUITING
University Clinical Center of Sarajevo, Sarajevo
RECRUITING
Integrare Therapeutics, Fortaleza
RECRUITING
Hospital Sao Rafael, Salvador
RECRUITING
Clinics Hospital, Federal University of Goias - (UFG), Goiânia
RECRUITING
Cetus Oncology Inc., Belo Horizonte
RECRUITING
Clinical Hospital of the Federal University of Parana (HC - UFPR), Curitiba
RECRUITING
Humane Clinic / Atena Research Institute, Mossoró
RECRUITING
Hospital Moinhos de Vento, Porto Alegre
RECRUITING
Integrated Oncology Center of Rio Grande do Sul - Mother of God Hospital, Porto Alegre
RECRUITING
Santa Catarina Health Research and Education Center (CEPEN), Florianópolis
RECRUITING
State University of Campinas (UNICAMP) - Hemocenter, Campinas
RECRUITING
Hospital Amaral Carvalho, Jaú
RECRUITING
Jewish Hospital Albert Einstein, São Paulo
RECRUITING
Samaritano Hospital, São Paulo
RECRUITING
Sao Paulo University Clinical Hospital, São Paulo
RECRUITING
Saint Lucas Hospital of Copacabana, Rio de Janeiro
RECRUITING
"University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski", Pleven
RECRUITING
"University Multiprofile Hospital for Active Treatment Sveti Georgi, Plovdiv", Plovdiv
RECRUITING
Multiprofile Hospital for Active Treatment - Sofia, part of Military Medical Academy, Sofia
RECRUITING
Specialized Hospital for Active Treatment of Hematological Diseases, Sofia
SUSPENDED
"Multiprofile Hospital for Active Treatment Sveta Marina", Varna
SUSPENDED
Tom Baker Cancer Center, Internal Medicine/Hematology, Calgary
COMPLETED
University of Alberta, Edmonton
RECRUITING
Providence Hematology - Vancouver, Vancouver
SUSPENDED
Eastern Regional Health Authority, St. John's
RECRUITING
Nova Scotia Health Authority, Centre for Clinical Research, Halifax
RECRUITING
Princess Margaret Cancer Centre, Toronto
RECRUITING
Jewish General Hospital; Clinical Research Unit, Montreal
RECRUITING
University Hospital Brno, Brno
RECRUITING
University Hospital Olomouc, Olomouc
RECRUITING
University Hospital Plzen, Pilsen
RECRUITING
University Hospital Kralovske Vinohrady, Clinic of Internal Hematology, Prague
SUSPENDED
La Conception Hospital, Marseille
RECRUITING
Hôpital Saint-Louis, Paris
RECRUITING
Centre Hospitalier Lyon-Sud, Pierre-Bénite
RECRUITING
University Hospital Center of Poitiers, Poitiers
RECRUITING
JSC K. Eristavi National Center For Experimental and Clinical Surgery, Tbilisi
COMPLETED
LTD M.Zodelava's Hematology Center, Department of Hematology, Tbilisi
COMPLETED
LTD S.Khechinashvili University Hospital, Tbilisi
COMPLETED
Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LTD, Tbilisi
RECRUITING
Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC, Tbilisi
COMPLETED
Semmelweis University SE ÁOK I. sz. Belgyógyászati Klinika, Budapest
RECRUITING
University of Debrecen Clinical Center (Debreceni Egyetem Klinikai Központ), Debrecen
RECRUITING
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
RECRUITING
Szabolcs-Szatmar-Bereg County Hospitals and University Teaching Hospital, Department of Hematology, Nyíregyháza
RECRUITING
Fejer County St. Gyorgy University Teaching Hospital, Department of Internal Medicine I, Székesfehérvár
RECRUITING
Gauhati Medical College and Hospital, Guwahati
RECRUITING
Nirmal Hospital Pvt Ltd, Surat
RECRUITING
Fortis Memorial Research Institute(FMRI), Gurgaon
RECRUITING
Sahyadri Super Speciality Hospital, Pune
RECRUITING
Shri Ram Cancer Centre, Mahatma Gandhi Medical College & Hospital, Jaipur
RECRUITING
Meenakshi Mission Hospital And Research Centre (MMHRC), Madurai
RECRUITING
Yashoda Hospitals, Hyderabad
RECRUITING
All India Institute of Medical Sciences, Dehradun
RECRUITING
Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata
RECRUITING
Tata Medical Center, Kolkata
RECRUITING
St. John's Medical College Hospital, Bengaluru
RECRUITING
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
RECRUITING
Max Super Speciality Hospital Saket (A Unit of Max Healthcare Institute Limited), Delhi
RECRUITING
Lady Davis Carmel Medical Center, Department of Hematology,, Haifa
RECRUITING
Hadassah Medical Center, Department of Hematology,, Jerusalem
RECRUITING
Meir Medical Center, Hematology Institute and Blood Bank, Kfar Saba
COMPLETED
Rabin Medical Center, Clinic for Myeloproliferative Disorders, Petah Tikva
COMPLETED
The Tel Aviv Sourasky Medical Center, Department of Internal Medicine, Tel Aviv
RECRUITING
"Cancer Institute Giovanni Paolo II, IRCCS", Bari
RECRUITING
Polyclinic S. Orsola-Malpighi, Bologna
RECRUITING
ASST Spedali Civili Brescia, Hematology Unit, Brescia
RECRUITING
Azienda Ospedaliero-Universitaria Careggi, Florence
RECRUITING
Scientific Institute of Romagna for the Study and Treatment of Cancer (IRST), IRCCS, Forlì
RECRUITING
Maggiore Polyclinic Hospital, Fondazione IRCCS Ca' Granda, Milan
RECRUITING
ASST Monza - Ospedale San Gerardo, Monza
RECRUITING
"University Hospital Federico II", Naples
RECRUITING
"University Hospital Maggiore della Carita of Novara", Novara
RECRUITING
United Hospitals Villa Sofia Cervello, Palermo
COMPLETED
Polyclinic San Matteo, IRCCS, Pavia
COMPLETED
"Hospital Infermi of Rimini", Rimini
RECRUITING
Umberto I Polyclinic of Rome, Rome
RECRUITING
"University Polyclinic Foundation Agostino Gemelli", Rome
RECRUITING
City of Health and Science of Turin, Turin
RECRUITING
Santa Maria della Misericordia University Hospital of Udine, Udine
RECRUITING
ASST Sette Laghi Hospital, Varese
RECRUITING
University of Yamanashi Hospital, Chūō
RECRUITING
Kyushu University Hospital, Fukuoka
RECRUITING
Fukushima Medical University Hospital, Fukushima
RECRUITING
Tohoku University Hospital, Miyagi
RECRUITING
University of Miyazaki Hospital, Miyazaki
RECRUITING
Juntendo University Hospital, Tokyo
RECRUITING
Nippon Medical School Hospital, Tokyo
RECRUITING
Tokyo Medical University Hospital, Tokyo
RECRUITING
Ehime University Hospital, Tōon
RECRUITING
Mie University Hospital, Tsu
RECRUITING
Aktobe Medical Center, Department of Hematology, Aktobe
RECRUITING
City Clinical Hospital #7, Hematology Department, Almaty
RECRUITING
Center for Hematology, Astana
RECRUITING
National Research Oncology, Oncohematology Center, Astana
RECRUITING
Hematology Center, Karaganda
RECRUITING
City Oncological Center, Shymkent
RECRUITING
Center for Hematology, Ust-Kamenogorsk
RECRUITING
University Teaching Hospital in Bialystok, Bialystok
RECRUITING
University Clinical Center in Gdansk, Gdansk
RECRUITING
Andrzej Mielecki Independent Public Clinical Hospital of Medical University of Silesia in Katowice, Department of Hematology and Bone Marrow Transplantation, Katowice
RECRUITING
Pratia Oncology Katowice, Katowice
RECRUITING
University Hospital in Krakow, Krakow
RECRUITING
Nicolaus Copernicus Provincial Multispecialty Oncology and Traumatology Center in Lodz, Lodz
RECRUITING
Independent Public Teaching Hospital No.1 in Lublin, Department of Hematooncology, Bone Marrow Transplantation and Chemotherapy, Lublin
RECRUITING
Jedrzej Sniadecki Specialist Hospital in Nowy Sacz, Department of Hematology, Nowy Sącz
COMPLETED
Frederic Chopin Provincial Teaching Hospital No. 1 in Rzeszow, Department of Hematology,, Rzeszów
SUSPENDED
Nasz Lekarz Medical Outpatient Clinics Slawomir Jeka, Torun
SUSPENDED
Institute of Hematology and Transfusion Medicine, Teaching Department of Hematology, Warsaw
RECRUITING
Jan Mikulicz Radecki University Hospital in Wroclaw, Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw
RECRUITING
Onco Card Srl, Brasov
RECRUITING
Coltea Clinical Hospital, Bucharest
RECRUITING
Fundeni Clinical Institute, Bucharest
RECRUITING
"Prof. Dr. Ion Chiricuta Institute of Oncology", Cluj-Napoca
COMPLETED
City Clinical Hospital #40, Moscow
COMPLETED
City Clinical Hospital n.a. V.V. Veresaev of the Moscow City Health, Moscow
COMPLETED
S.P. Botkin City Clinical Hospital, Moscow
COMPLETED
Clinic UZI 4D, LLC, Pyatigorsk
COMPLETED
Research Institute of Hematology and Transfusiology, Saint Petersburg
COMPLETED
S.M. Kirov Military Medical Academy, Department and Clinic for Intermediate-Level Training in Internal Medicine, Hematology Division, Saint Petersburg
COMPLETED
V.A. Almazov North-West Federal Medical Research Center, Institute of Oncology and Hematology, Scientific Department of Clinical Oncology, Saint Petersburg
COMPLETED
Bashkiria State Medical University, Department of Internal Medicine, Ufa
COMPLETED
Volgograd Regional Clinical Oncology Center, Volgograd
RECRUITING
Clinical Center of Serbia, Clinic of Hematology, Belgrade
SUSPENDED
Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad
RECRUITING
Pusan National University Hospital, Busan
RECRUITING
Kyungpook National University Hospital, Daegu
RECRUITING
Samsung Medical Center, Seoul
RECRUITING
Seoul National University Hospital, Seoul
RECRUITING
The Catholic University of Korea, St. Mary's Hospital, Seoul
RECRUITING
Hospital Clínic de Barcelona, Barcelona
SUSPENDED
Hospital del Mar, Barcelona
RECRUITING
University Hospital Vall d'Hebron, Barcelona
RECRUITING
Hospital Universitario Ramón y Cajal, Madrid
RECRUITING
University Hospital 12 de Octubre, Department of Hematology, Madrid
SUSPENDED
Morales Meseguer University General Hospital, Department of Hematology and Hemotherapy, Murcia
RECRUITING
University Clinical Hospital of Salamanca, Department of Hematology, Salamanca
RECRUITING
University Hospital Virgen del Rocio (HUVR), Seville
SUSPENDED
University Clinical Hospital of Valencia, Department of Hematology and Medical Oncology, Valencia
COMPLETED
Cherkasy Regional Oncology Dispensary of Cherkasy Oblast Council, Regional Treatment and Diagnostic Hematology Center, Department of Hematology, Cherkasy
COMPLETED
"City Clinical Hospital #4 under Dnipro City Council", Dnipro
COMPLETED
"Communal Non-profit enterprise Regional Center of Oncology, Department of Hematology", Kharkiv
COMPLETED
Kyiv City Clinical Hospital #9, Hematology Department #1, Kyiv
COMPLETED
Kyiv Regional Oncology Center, Department of Hematology,, Kyiv
COMPLETED
"Limited Liability Company City Doctor", Kyiv
COMPLETED
Institute of Blood Pathology and Transfusion Medicine, Department of Hematology, Lviv
COMPLETED
Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council, Department of Hematology, Poltava
COMPLETED
Royal Hallamshire Hospital, Department of Hematology, Sheffield
RECRUITING
Gloucestershire Royal Hospital, Gloucester
RECRUITING
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London
RECRUITING
Imperial College Healthcare NHS Trust - Hammersmith Hospital, London
RECRUITING
Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford
COMPLETED
Beatson West of Scotland Cancer Centre, Glasgow
RECRUITING
Barts Health NHS Trust - The Royal London Hospital, London
Lead Sponsor
Collaborators (1)
PSI CRO
INDUSTRY
Swedish Orphan Biovitrum
INDUSTRY