A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

August 4, 2014

Primary Completion Date

May 18, 2021

Study Completion Date

May 18, 2021

Conditions
Hemophagocytic Lymphohistiocytosis
Interventions
DRUG

Emapalumab

Treatment with emapalumab is not planned for all enrolled participants. For participants who will continue receiving emapalumab in the context of this study (NI-0501-05), the dose and timing will be either carried forward from the last administered emapalumab dose as part of the parent study in which the participant was enrolled, or an adjusted dose will be administered, if necessary.

Trial Locations (16)

20900

Fondazione MBBM c/o Ospedale San Gerardo Clinica Pediatrica, Monza

27599

University of North Carolina at Chapel Hill, Chapel Hill

28009

Hospital Universitario Niño Jesús Servicio de Hemato-Oncología Pediátrica, Madrid

35128

Azienda Ospedaliera Padova, Padua

37126

Ospedale della Donna e del Bambino - U.O.C. Oncoematologia Pediatrica, Verona

45229

Cincinnati Children's Hospital, Cincinnati

49503

Spectrum Health Helen Devos Children's Hospital, Grand Rapids

75743

Hôpital Necker-Enfants Malades, Paris

77030

Texas Children's Cancer Center, Houston

45229-3039

Cincinnati Children's Hospital - Division of Immunobiology, Cincinnati

00165

Ospedale Pediatrico Bambino Gesu - UO Reumatologia, Rome

Ospedale Pediatrico Bambino Gesu, Rome

08035

Hospital Universitario Vall d'Hebron Servei de Hematologia i Oncologia, Barcelona

08950

Sant Joan de Déu Hospital - Pediatric Rheumatology Department, Barcelona

WC1N1EH

UCL Institute of Child Health Great Ormond Street Hospital, London

WC1N3JH

Great Ormond Street Hospital - Department of Haematology, London

Sponsors
All Listed Sponsors
collaborator

Seventh Framework Programme

OTHER

lead

Swedish Orphan Biovitrum

INDUSTRY

NCT02069899 - A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody | Biotech Hunter | Biotech Hunter