Anakinra and Kawasaki Disease

PHASE2CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

February 5, 2016

Primary Completion Date

January 21, 2019

Study Completion Date

February 18, 2019

Conditions
Kawasaki DiseaseChildren
Interventions
DRUG

Anakinra

The dose of Anakinra will be 2mg/kg (patients \<10kg and/or \<8 months: 4mg/kg). If the patient remains febrile (fever \>38°C), he will receive a double dose of anakinra 4mg/kg (patients \<10kg and/or \<8 months: 6mg/kg) at day1 instead of 2mg/kg. If the patient does not respond to the 4mg/kg dose at visit 3; d1 within 24 hours, he will receive at visit 4; d2, 6mg/kg of anakinra (patients \<10kg and/or \<8 months: 8mg/kg). Treatment will be continued until they have achieved complete response as defined in the outcome measurement section, and during a maximum of 15 days.

Trial Locations (1)

94275

AP-HP,Bicêtre Hospital, Le Kremlin-Bicêtre

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Swedish Orphan Biovitrum

INDUSTRY

lead

Assistance Publique - Hôpitaux de Paris

OTHER