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Clinical Trials for Mirati Therapeutics
Explore 17 clinical trials worldwide
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Showing 1-17 of 17 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Mirati Therapeutics
Clinical Trials (17)
NCT06875310
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
PHASE3
Recruiting
630 participants
Started: Apr 24, 2025 · Completed: Apr 30, 2032
1 condition
1 sponsor
329 locations
NCT06248606
Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases
PHASE2
Recruiting
30 participants
Started: Aug 6, 2024 · Completed: Aug 31, 2028
3 conditions
3 sponsors
1 location
NCT05853575
Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)
PHASE2
Recruiting
200 participants
Started: Feb 16, 2024 · Completed: Jul 30, 2026
3 conditions
1 sponsor
120 locations
NCT06130254
Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers
PHASE1
Recruiting
52 participants
Started: Jan 30, 2024 · Completed: Aug 25, 2030
2 conditions
2 sponsors
1 location
NCT05722327
Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer
PHASE1
Active, not recruiting
24 participants
Started: Dec 6, 2023 · Completed: Sep 30, 2027
2 conditions
2 sponsors
1 location
NCT06026410
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
PHASE1
Recruiting
270 participants
Started: Oct 18, 2023 · Completed: Apr 30, 2027
6 conditions
2 sponsors
32 locations
NCT05673187
Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status
PHASE2
Active, not recruiting
68 participants
Started: Jun 12, 2023 · Completed: Mar 1, 2026
2 conditions
2 sponsors
22 locations
NCT05578092
A Phase 1/2 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway
PHASE1/PHASE2
Active, not recruiting
228 participants
Started: Dec 2, 2022 · Completed: Jul 30, 2026
4 conditions
1 sponsor
18 locations
NCT05609578
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
PHASE2
Recruiting
90 participants
Started: Nov 22, 2022 · Completed: Dec 1, 2026
2 conditions
1 sponsor
166 locations
NCT05375994
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
PHASE1/PHASE2
Active, not recruiting
85 participants
Started: Aug 1, 2022 · Completed: Jan 1, 2026
6 conditions
2 sponsors
8 locations
NCT04793958
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
PHASE3
Active, not recruiting
461 participants
Started: Jun 24, 2021 · Completed: Jan 30, 2026
2 conditions
1 sponsor
419 locations
NCT04685135
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
PHASE3
Active, not recruiting
453 participants
Started: Feb 23, 2021 · Completed: Jul 2, 2026
2 conditions
1 sponsor
343 locations
NCT04613596
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
PHASE2/PHASE3
Recruiting
806 participants
Started: Dec 2, 2020 · Completed: Oct 31, 2029
2 conditions
1 sponsor
740 locations
NCT04299113
Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma
PHASE1
Active, not recruiting
38 participants
Started: May 14, 2020 · Completed: May 22, 2027
1 condition
3 sponsors
1 location
NCT03785249
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
PHASE1/PHASE2
Active, not recruiting
731 participants
Started: Jan 15, 2019 · Completed: Dec 31, 2026
3 conditions
1 sponsor
222 locations
NCT03220477
Pembrolizumab (Immunotherapy Drug) in Combination With Guadecitabine and Mocetinostat (Epigenetic Drugs) for Patients With Advanced Lung Cancer.
PHASE1
Active, not recruiting
28 participants
Started: Aug 4, 2017 · Completed: Jul 31, 2026
1 condition
6 sponsors
3 locations
NCT02664935
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
PHASE2
Active, not recruiting
423 participants
Started: May 31, 2015 · Completed: Sep 30, 2025
3 conditions
6 sponsors
25 locations