Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

461

Participants

Timeline

Start Date

June 24, 2021

Primary Completion Date

January 30, 2026

Study Completion Date

January 30, 2026

Conditions
Advanced Colorectal CancerMetastatic Colorectal Cancer
Interventions
DRUG

MRTX849

28 Day Cycle

BIOLOGICAL

Cetuximab

28 Day Cycle

DRUG

mFOLFOX6 Regimen

"* Fluorouracil~* Oxaliplatin~* Folinic acid"

DRUG

FOLFIRI Regimen

"* Fluorouracil~* Irinotecan~* Folinic acid"

Trial Locations (419)

0

Local Institution - 010-462, Bogotá

Local Institution - 010-465, Floridablanca

Local Institution - 010-048, Central

Local Institution - 010-046, Hong Kong

4

Local Institution - 010-250, Dublin

9

Local Institution - 010-252, Dublin

333

Local Institution - 010-125, Taoyuan District

500

Local Institution - 010-129, Changhua

704

Local Institution - 010-122, Tainan City

807

Local Institution - 010-121, Kaohsiung City

1061

Local Institution - 010-432, CABA

1090

Local Institution - 010-144, Vienna

Local Institution - 010-154, Brussels

2065

Local Institution - 010-006, Garran

2100

Local Institution - 010-171, Copenhagen

2298

Local Institution - 010-002, Waratah

2650

Local Institution - 010-157, Edegem

2700

Local Institution - 010-143, Wiener Neustadt

3004

Local Institution - 010-012, Melbourne

3084

Local Institution - 010-015, Heidelberg

3168

Local Institution - 010-004, Clayton

5000

Local Institution - 010-172, Odense

5042

Local Institution - 010-005, Bedford Park

6020

Local Institution - 010-145, Innsbruck

7100

Local Institution - 010-170, Vejle

9000

Local Institution - 010-156, Ghent

9042

Local Institution - 010-299, Cagliari

10002

Local Institution - 010-120, Taipei

10016

Local Institution - 010-813, New York

10028

Local Institution - 010-535 - G, New York

10029

Local Institution - 010-998, New York

10060

Local Institution - 010-286, Candiolo

10065

Local Institution - 010-918, New York

10110

Local Institution - 010-133, Khlong Toey

10117

Local Institution - 010-657, Berlin

10128

Local Institution - 010-289, Torino

10400

Local Institution - 010-134, Bangkok

10408

Local Institution - 010-117, Goyang-si

10469

Local Institution - 010-535 - E, The Bronx

10604

Local Institution - 010-918 - F, Harrison

10700

Local Institution - 010-132, Bang Phlat

11528

Local Institution - 010-501, Athens

11553

Local Institution - 010-918 - E, Uniondale

11702

Local Institution - 010-535 - D, Babylon

11725

Local Institution - 010-918 - A, Commack

11772

Local Institution - 010-535 - C, Patchogue

11776

Local Institution - 010-535 - A, Port Jefferson

Local Institution - 010-535 - B, Port Jefferson Station

11901

Local Institution - 010-535 - F, Riverhead

11967

Local Institution - 010-535, Shirley

13005

Local Institution - 010-682, Marseille

13496

Local Institution - 010-520, Seongnam-si

13875

Local Institution - 010-290, Biella

14004

Local Institution - 010-621, Córdoba

14068

Local Institution - 010-116, Anyang-si

14080

Local Institution - 010-473, Mexico City

15006

Local Institution - 010-613, A Coruña

15212

Local Institution - 010-596, Pittsburgh

16247

Local Institution - 010-115, Suwon

20141

Local Institution - 010-278, Milan

20162

Local Institution - 010-293, Milan

20521

Local Institution - 010-181, Turku

21079

Local Institution - 010-192, Dijon

21201

Local Institution - 010-534, Baltimore

23229

Local Institution - 010-539, Richmond

23298

Local Institution - 010-536, Richmond

24408

Local Institution - 010-597, Fredericksburg

25000

Local Institution - 010-208, Besançon

27534

Local Institution - 010-585, Goldsboro

28007

Local Institution - 010-619, Madrid

28040

Local Institution - 010-601, Madrid

28041

Local Institution - 010-617, Madrid

28046

Local Institution - 010-624, Madrid

28328

Local Institution - 010-585-B, Clinton

28546

Local Institution - 010-585-A, Jacksonville

29038

Local Institution - 010-474, Tuxtla Gutiérrez

29200

Local Institution - 010-194, Brest

29607

Local Institution - 010-981, Greenville

30265

Local Institution - 010-986, Newnan

30322

Local Institution - 010-956, Atlanta

31008

Local Institution - 010-623, Pamplona

31059

Local Institution - 010-680, Toulouse

32224

Local Institution - 010-829, Jacksonville

32308

Local Institution - 010-924, Tallahassee

32804

Local Institution - 010-896, Orlando

32806

Local Institution - 010-988, Orlando

33000

Local Institution - 010-669, Bordeaux

33136

Local Institution - 010-990, Miami

33331

Local Institution - 010-537, Weston

33401

Local Institution - 010-926, West Palm Beach

33520

Local Institution - 010-182, Tampere

33705

Local Institution - 010-923, St. Petersburg

33720

Local Institution - 010-660, Pessac

33770

Local Institution - 010-923-A, Largo

Local Institution - 010-923-B, Largo

Local Institution - 010-923-C, Largo

Local Institution - 010-923-D, Largo

Local Institution - 010-923-E, Largo

Local Institution - 010-923-F, Largo

Local Institution - 010-923-G, Largo

Local Institution - 010-923-H, Largo

Local Institution - 010-923-I, Largo

Local Institution - 010-923-J, Largo

Local Institution - 010-923-K, Largo

Local Institution - 010-923-L, Largo

Local Institution - 010-923-M, Largo

Local Institution - 010-923-N, Largo

Local Institution - 010-923-O, Largo

Local Institution - 010-923-P, Largo

33901

Local Institution - 010-922, Fort Myers

33905

Local Institution - 010-922-B, Fort Myers

33908

Local Institution - 010-922-C, Fort Myers

33909

Local Institution - 010-922-E, Cape Coral

33980

Local Institution - 010-922-H, Port Charlotte

34102

Local Institution - 010-922-F, Naples

Local Institution - 010-922-G, Naples

34135

Local Institution - 010-922-A, Bonita Springs

34211

Local Institution - 010-922-D, Bradenton

34474

Local Institution - 010-538, Ocala

34655

Local Institution - 010-984-A, Trinity

34691

Local Institution - 010-984-B, Holiday

35007

Local Institution - 010-855-E, Alabaster

35015

Local Institution - 010-525, Daejeon

35022

Local Institution - 010-855-B, Bessemer

35128

Local Institution - 010-297, Padua

35209

Local Institution - 010-855-D, Birmingham

35211

Local Institution - 010-855-A, Birmingham

35235

Local Institution - 010-855-F, Birmingham

35243

Local Institution - 010-855-C, Birmingham

Local Institution - 010-855, Birmingham

37044

Local Institution - 010-209, Tours

37170

Local Institution - 010-209-A, Chambray-lès-Tours

37203

Local Institution - 010-801, Nashville

37404

Local Institution - 010-921, Chattanooga

39008

Local Institution - 010-604, Santander

40022

Local Institution - 010-424, Sumy

40705

Local Institution - 010-124, Taichung

41063

Local Institution - 010-228, Mönchengladbach

41110

Local Institution - 010-235, Larissa

42100

Local Institution - 010-291, Reggio Emilia

44280

Local Institution - 010-472, Guadalajara

44625

Local Institution - 010-658, Herne

44670

Local Institution - 010-477, Guadalajara

44791

Local Institution - 010-655, Bochum

45211

Local Institution - 010-893, Cincinnati

46010

Local Institution - 010-618, Valencia

46014

Local Institution - 010-625, Valencia

46050

Local Institution - 010-071, Petaling Jaya

47014

Local Institution - 010-270, Meldola

48108

Local Institution - 010-111, Busan

48126

Local Institution - 010-531C, Dearborn

48183

Local Institution - 010-531A, Brownstown

48202

Local Institution - 010-531, Detroit

48377

Local Institution - 010-531B, Novi

50200

Local Institution - 010-131, Chiang Mai

50586

Local Institution - 010-073, Kuala Lumpur

50603

Local Institution - 010-074, Kuala Lumpur

50612

Local Institution - 010-524, Yangsan

52242

Local Institution - 010-991, Iowa City

53226

Local Institution - 010-947, Milwaukee

54645

Local Institution - 010-231, Thessaloniki

55041

Local Institution - 010-287, Lido di Camaiore

55404

Local Institution - 010-875, Minneapolis

55416

Local Institution - 010-838, Saint Louis Park

55426

Local Institution - 010-838A, Saint Louis Park

Local Institution - 010-838B, Saint Louis Park

Local Institution - 010-838C, Saint Louis Park

Local Institution - 010-838D, Saint Louis Park

Local Institution - 010-838E, Saint Louis Park

Local Institution - 010-838F, Saint Louis Park

Local Institution - 010-838G, Saint Louis Park

Local Institution - 010-838H, Saint Louis Park

Local Institution - 010-838I, Saint Louis Park

Local Institution - 010-838J, Saint Louis Park

Local Institution - 010-838K, Saint Louis Park

Local Institution - 010-838L, Saint Louis Park

Local Institution - 010-838M, Saint Louis Park

55905

Local Institution - 010-830, Rochester

56126

Local Institution - 010-294, Pisa

57001

Local Institution - 010-230, Thessaloniki

58128

Local Institution - 010-100, Hwasun-gun

59037

Local Institution - 010-662, Lille

60099

Local Institution - 010-994, Zion

60488

Local Institution - 010-229, Frankfurt am Main

60540

Local Institution - 010-963, Naperville

62250

Local Institution - 010-072, Putrajaya

62290

Local Institution - 010-476, Cuernavaca

65804

Local Institution - 010-541, Springfield

68130

Local Institution - 010-590, Omaha

68510

Local Institution - 010-564, Lincoln

69008

Local Institution - 010-205, Lyon

70809

Local Institution - 010-920, Baton Rouge

71110

Local Institution - 010-238, Heraklion

72762

Local Institution - 010-978, Springdale

72764

Local Institution - 010-652, Reutlingen

73104

Local Institution - 010-532, Oklahoma City

73120

Local Institution - 010-549, Oklahoma City

73657

Local Institution - 010-123, Tainan City

74146

Local Institution - 010-584, Tulsa

75010

Local Institution - 010-207, Paris

75012

Local Institution - 010-203, Paris

75013

Local Institution - 010-204, Paris

75015

Local Institution - 010-661, Paris

75063

Local Institution - 010-999, Irving

75216

Local Institution - 010-572, Dallas

75246

Local Institution - 010-879, Dallas

75601

Local Institution - 010-878-B, Longview

75702

Local Institution - 010-878, Tyler

76508

Local Institution - 010-964, Temple

76800

Local Institution - 010-475, San Juan del Río

77008

Local Institution - 010-577-B, Houston

77024

Local Institution - 010-577-A, Houston

77030

Local Institution - 010-577, Houston

Local Institution - 010-848, Houston

77090

Local Institution - 010-977, Houston

78240

Local Institution - 010-862, San Antonio

80012

Local Institution - 010-872-H, Aurora

80045

Local Institution - 010-810, Aurora

80112

Local Institution - 010-872-E, Centennial

80131

Local Institution - 010-271, Napoli

80218

Local Institution - 010-872, Denver

Local Institution - 010-872-F, Littleton

80220

Local Institution - 010-872-B, Denver

80228

Local Institution - 010-872-J, Lakewood

80260

Local Institution - 010-872-D, Thornton

80303

Local Institution - 010-872-A, Boulder

80501

Local Institution - 010-872-G, Longmont

80907

Local Institution - 010-872-C, Colorado Springs

81008

Local Institution - 010-872-I, Pueblo

81100

Local Institution - 010-070, Johor Bahru

81377

Local Institution - 010-650, München

81737

Local Institution - 010-226, München

83100

Local Institution - 010-292, Avellino

84003

Local Institution - 010-976-F, American Fork

84010

Local Institution - 010-976-C, Bountiful

84041

Local Institution - 010-976-D, Layton

84088

Local Institution - 010-976-E, West Jordan

84102

Local Institution - 010-976-B, Salt Lake City

84106

Local Institution - 010-976, Salt Lake City

84157

Local Institution - 010-976-A, Murray

84405

Local Institution - 010-976-H, Ogden

84604

Local Institution - 010-976-G, Provo

84918

Local Institution - 010-668, Avignon

85054

Local Institution - 010-989, Phoenix

85234

Local Institution - 010-996, Gilbert

85338

Local Institution - 010-566, Goodyear

88996

Local Institution - 010-077, Kota Kinabalu

89052

Local Institution - 010-860 - A, Henderson

Local Institution - 010-860-F, Henderson

89074

Local Institution - 010-860-B, Henderson

89081

Local Institution - 010-676, Ulm

89128

Local Institution - 010-860-D, Las Vegas

89144

Local Institution - 010-860-C, Las Vegas

89148

Local Institution - 010-860-E, Las Vegas

89169

Local Institution - 010-860, Las Vegas

90033

Local Institution - 010-958A, Los Angeles

Local Institution - 010-958, Los Angeles

90048

Local Institution - 010-551, Los Angeles

90110

Local Institution - 010-130, Hat Yai

90404

Local Institution - 010-561, Santa Monica

90505

Local Institution - 010-574, Torrance

90602

Local Institution - 010-570, Whittier

91342

Local Institution - 010-571, Sylmar

91911

Local Institution - 010-979C, Chula Vista

91942

Local Institution - 010-979A, La Mesa

92123

Local Institution - 010-979B, San Diego

Local Institution - 010-979D, San Diego

Local Institution - 010-979, San Diego

92150

Local Institution - 010-667, Suresnes

92224

Local Institution - 010-675, Amberg

92373

Local Institution - 010-563, Redlands

92663

Local Institution - 010-847, Newport Beach

92835

Local Institution - 010-851, Fullerton

93309

Local Institution - 010-573, Bakersfield

93701

Local Institution - 010-980, Fresno

94115

Local Institution - 010-982, San Francisco

94300

Local Institution - 010-471, Colonia Centro Orizaba

94805

Local Institution - 010-202, Villejuif

98001

Local Institution - 010-533 A, Auburn

98201

Local Institution - 010-576, Everett

98335

Local Institution - 010-533 B, Gig Harbor

98372

Local Institution - 010-533 C, Puyallup

98405

Local Institution - 010-533, Tacoma

98684

Local Institution - 010-885, Vancouver

100021

Local Institution - 010-717, Beijing

110001

Local Institution - 010-709, Shenyang

110042

Local Institution - 010-705, Shenyang

119074

Local Institution - 010-090, Singapore

130012

Local Institution - 010-030, Changchun

130021

Local Institution - 010-718, Changchun

168583

Local Institution - 010-093, Singapore

188770

Local Institution - 010-095, Singapore

200025

Local Institution - 010-025, Shanghai Shi

200032

Local Institution - 010-024, Shanghaishi

200080

Local Institution - 010-038, Shanghai

Local Institution - 010-033, Hongkou Qu

200120

Local Institution - 010-020, Shanghai

200240

Local Institution - 010-708, Shanghai

200746

Local Institution - 010-343, Craiova

210029

Local Institution - 010-704, Nanjing

214400

Local Institution - 010-714, Jiangyin

217562

Local Institution - 010-092, Singapore

230001

Local Institution - 010-026, Hefei

230022

Local Institution - 010-022, Hefei

230031

Local Institution - 010-711, Hefei

233004

Local Institution - 010-712, Bengbu

250117

Local Institution - 010-036, Jinan

258499

Local Institution - 010-091, Singapore

300060

Local Institution - 010-027, Tianjin

300239

Local Institution - 010-510, Timișoara

310009

Local Institution - 010-707, Hangzhou

310016

Local Institution - 010-032, Hangzhou

310022

Local Institution - 010-034, Hangzhou

330006

Local Institution - 010-706, Nanchang

350014

Local Institution - 010-029, Fuzhou

400015

Local Institution - 010-344, Cluj-Napoca

400641

Local Institution - 010-340, Cluj-Napoca

410008

Local Institution - 010-035, Changsha

430030

Local Institution - 010-703, Wuhan

430031

Local Institution - 010-347, Baia Mare

430079

Local Institution - 010-701, Wuhan

450008

Local Institution - 010-021, Zhengzhou

500152

Local Institution - 010-349, Brasov

510655

Local Institution - 010-031, Guangzhou

518036

Local Institution - 010-713, Shenzhen

530021

Local Institution - 010-715, Nanning

610044

Local Institution - 010-710, Chengdu

641199

Local Institution - 010-716, Neijiang

905900

Local Institution - 010-511, Ovidiu

06360

Local Institution - 010-949, Norwich

33709-2236

Local Institution - 010-984, St. Petersburg

46237-8601

Local Institution - 010-569-A, Indianapolis

Local Institution - 010-569, Indianapolis

02215

Local Institution - 010-997, Boston

07920

Local Institution - 010-918 - B, Basking Ridge

07109

Local Institution - 010-993, Belleville

08816

Local Institution - 010-975, East Brunswick

07932

Local Institution - 010-992, Florham Park

07748

Local Institution - 010-918 - D, Middletown

07645

Local Institution - 010-918 - C, Montvale

08903-2681

Local Institution - 010-957, New Brunswick

22031-4630

Local Institution - 010-919, Fairfax

98109--1023

Local Institution - 010-824, Seattle

26506-9300

Local Institution - 010-575, Morgantown

C1426ANZ

Local Institution - 010-434, Buenos Aires

CI264 AAA

Local Institution - 010-431, Buenos Aires

F5300COE

Local Institution - 010-430, La Rioja

91350-200

Local Institution - 010-448, Porto Alegre

R8500ACE

Local Institution - 010-433, Viedma

B-5530

Local Institution - 010-150, Yvoir

98700-000

Local Institution - 010-446, Ijuí

90035-903

Local Institution - 010-443, Porto Alegre

89010-340

Local Institution - 010-450, Blumenau

80040-170

Local Institution - 010-442, Curitiba

01509-010

Local Institution - 010-449, Liberdade

09060-650

Local Institution - 010-444, Santo André

15090-000

Local Institution - 010-440, São José do Rio Preto

01246-000

Local Institution - 010-441, São Paulo

01323-030

Local Institution - 010-445, São Paulo

04543-000

Local Institution - 010-447, São Paulo

K1H 8L6

Local Institution - 010-481, Ottawa

M5B 1W8

Local Institution - 010-483, Toronto

M5G 2M9

Local Institution - 010-482, Toronto

H1T 2M4

Local Institution - 010-487, Montreal

080020

Local Institution - 010-460, Barranquilla

050034

Local Institution - 010-463, Medellín

656 53

Local Institution - 010-165, Brno

656 91

Local Institution - 010-160, Brno

779 00

Local Institution - 010-162, Olomouc

150 06

Local Institution - 010-161, Prague

FI-00029

Local Institution - 010-180, Helsinki

01307

Local Institution - 010-227, Dresden

D-20249

Local Institution - 010-656, Hamburg

155 62

Local Institution - 010-232, Cholargós

D07 R2WY

Local Institution - 010-253, Dublin

D07 WKW8

Local Institution - 010-254, Dublin

D24 NR0A

Local Institution - 010-251, Dublin

00144

Local Institution - 010-295, Roma

1066 CX

Local Institution - 010-632, Amsterdam

1081 HV

Local Institution - 010-306, Amsterdam

6525 GA

Local Institution - 010-630, Nijmegen

3543 AZ

Local Institution - 010-307, Utrecht

80-219

Local Institution - 010-328, Gdansk

05-400

Local Institution - 010-327, Otwock

02-034

Local Institution - 010-322, Warsaw

02-507

Local Institution - 010-787, Warsaw

4710-243

Local Institution - 010-332, Braga

1400-038

Local Institution - 010-337, Lisbon

1649-035

Local Institution - 010-640, Lisbon

4099-001

Local Institution - 010-331, Porto

4200-072

Local Institution - 010-339, Porto

00919

Local Institution - 010-902, San Juan

00927

Local Institution - 010-903, San Juan

00935

Local Institution - 010-900, San Juan

022328

Local Institution - 010-512, Bucharest

602-812

Local Institution - 010-119, Busan

02841

Local Institution - 010-105, Seoul

03080

Local Institution - 010-108, Seoul

03722

Local Institution - 010-118, Seoul

05505

Local Institution - 010-104, Seoul

06351

Local Institution - 010-114, Seoul

06591

Local Institution - 010-109, Seoul

08916

Local Institution - 010-610, Badalona

08035

Local Institution - 010-612, Barcelona

08036

Local Institution - 010-600, Barcelona

08908

Local Institution - 010-620, LHospitalet de Llobregat

08208

Local Institution - 010-622, Sabadell

AB25 2ZN

Local Institution - 010-412, Aberdeen

B15 2WB

Local Institution - 010-410, Birmingham

CB2 0QQ

Local Institution - 010-413, Cambridge

BH7 7DW

Local Institution - 010-411, Dorset

G12 0XH

Local Institution - 010-400, Glasgow

ME16 9QQ

Local Institution - 010-403, Kent

LS9 7TF

Local Institution - 010-414, Leeds

NW1 2BU

Local Institution - 010-402, London

SW3 6JJ

Local Institution - 010-405, London

Local Institution - 010-406, London

M20 4BX

Local Institution - 010-407, Manchester

HA6 2RN

Local Institution - 010-404, Middlesex

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY