A Phase 1/2 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

228

Participants

Timeline

Start Date

December 2, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

July 30, 2026

Conditions
Solid TumorAdvanced Solid TumorNon Small Cell Lung CancerColo-rectal Cancer
Interventions
DRUG

MRTX0902

SOS1 inhibitor

DRUG

MRTX849

KRAS G12C inhibitor

Trial Locations (18)

15232

Local Institution - 001-116, Pittsburgh

21287

Local Institution - 001-103, Baltimore

22031

Local Institution - 001-104, Fairfax

37203

Local Institution - 001-101, Nashville

Local Institution - 001-102, Nashville

77030

Local Institution - 001-107, Houston

98109

Local Institution - 001-105, Seattle

06520

Local Institution - 001-108, New Haven

19713-2055

Local Institution - 001-119, Newark

32827-7400

Local Institution - 001-111, Orlando

55905-0001

Local Institution - 001-110, Rochester

07601-2191

Local Institution - 001-115, Hackensack

45219-2364

Local Institution - 001-106, Cincinnati

97239-3011

Local Institution - 001-109, Portland

75246-2003

Local Institution - 001-112, Dallas

76104-2154

Local Institution - 001-122, Fort Worth

75708-3154

Local Institution - 001-123, Tyler

00935

Local Institution - 001-114, Rio Piedras

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY

NCT05578092 - A Phase 1/2 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway | Biotech Hunter | Biotech Hunter