Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

453

Participants

Timeline

Start Date

February 23, 2021

Primary Completion Date

December 30, 2023

Study Completion Date

July 2, 2026

Conditions
Metastatic Non Small Cell Lung CancerAdvanced Non Small Cell Lung Cancer
Interventions
DRUG

MRTX849

21 day cycles

DRUG

Docetaxel

21 day cycles

Trial Locations (343)

0

Humanity & Health Clinical Trial Centre, Central

Prince of Wales Hospital - Hong Kong, Hong Kong

Hong Kong United Oncology Centre, Kowloon

4

St. Vincents University Hospital, Dublin

9

Beaumont Hospital - Dublin, Dublin

1083

Local Institution - 012-242, Budapest

1090

Universitair Ziekenhuis Brussel, Brussels

1121

Local Institution - 012-244, Budapest

1122

Local Institution - 012-241, Budapest

1160

Wiener Gesundheitsverbund - Klinik Ottakring, Vienna

2045

Reformatus Pulmonologiai Centrum, Törökbálint

2065

Local Institution - 012-013, St Leonards

2485

Local Institution - 012-019, Tweed Heads

2500

Cancer Care Wollongong, Wollongong

2650

Local Institution - 012-157, Edegem

3010

Local Institution - 012-769, Alicante

3168

Local Institution - 012-004, Clayton

3200

Local Institution - 012-243, Gyöngyös

3500

Local Institution - 012-158, Hasselt

3604

Spital Simmental-Thun-Saanenland, Thun

4031

Universitatsspital Basel, Basel

4102

Princess Alexandra Hospital, Woolloongabba

4740

Local Institution - 012-016, Mackay

4814

Townsville University Hospital, Douglas

5020

Uniklinikum Salzburg, Salzburg

5042

Local Institution - 012-005, Bedford Park

5700

Local Institution - 012-763, Gyula

6060

Local Institution - 012-151, Gilly

8000

Local Institution - 012-759, Székesfehérvár

8401

Kantonsspital Winterthur, Winterthur

8800

Local Institution - 012-152, Roeselare

9000

Local Institution - 012-155, Ghent

9020

Klinikum Klagenfurt Am Worthersee, Klagenfurt

9600

Algemeen Ziekenhuis Glorieux Ronse, Ronse

10060

Local Institution - 012-286, Candiolo

11526

Henry Dunant Hospital Center, Athens

11527

Local Institution - 012-236, Athens

13009

Institut Paoli-Calmettes, Marseille

13015

Hopital Nord de Marseille, Marseille

13496

Local Institution - 012-520, Seongnam-si

13620

Local Institution - 012-112, Seongnam-si

14004

Local Institution - 012-621, Córdoba

14033

Local Institution - 012-193, Caen

14076

Local Institution - 012-196, Caen

14341

Hospital CUF Porto, Porto

15006

Local Institution - 012-613, A Coruña

15121

Local Institution - 012-276, Alessandria

16100

Local Institution - 012-273, Genova

16132

Local Institution - 012-285, Genova

16247

Catholic University of Korea St. Vincents Hospital, Suwon

16499

Local Institution - 012-107, Suwon

17007

Local Institution - 012-764, Girona

18014

Local Institution - 012-616, Granada

20132

Local Institution - 012-296, Milan

20133

Local Institution - 012-283, Milan

20141

Local Institution - 012-278, Milan

20155

Local Institution - 012-814 - C, Gainesville

20176

Local Institution - 012-814 - D, Leesburg

21079

Local Institution - 012-192, Dijon

21565

Local Institution - 012-103, Incheon

21702

Frederick Health, Frederick

22031

Local Institution - 012-814 - A, Fairfax

NEXT Virginia, Fairfax

22205

Local Institution - 012-814 - B, Arlington

22927

LungenClinic Grosshansdorf, Grohansdorf

23538

Local Institution - 012-216, Lübeck

24071

Hospital de Leon, León

25123

Local Institution - 012-765, Brescia

26121

Pius-Hospital Oldenburg, Oldenburg

27003

Local Institution - 012-615, Lugo

28007

Local Institution - 012-607, Madrid

28027

Clinica Universidad de Navarra - Madrid, Madrid

28034

Local Institution - 012-606, Madrid

28040

Local Institution - 012-601, Madrid

Local Institution - 012-609, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28100

Local Institution - 012-770, Novara

28222

Local Institution - 012-626, Majadahonda

28644

Chungbuk National University Hospital, Cheongju-si

29009

Local Institution - 012-608, Málaga

29107

Centre Hospitalier de Cornouaille - Hopital Laennec, Quimper

29200

Local Institution - 012-194, Brest

29605

Prisma Health Cancer Institute - Faris Road, Greenville

30060

Northwest Georgia Oncology Centers Wellstar - Marietta, Marietta

30106

Local Institution - 012-835 - A, Austell

30117

Local Institution - 012-835 - B, Carrollton

30121

Local Institution - 012-835 - C, Cartersville

30134

Local Institution - 012-835 - D, Douglasville

30607

University Cancer & Blood Center (UCBC) - Athens, Athens

31008

Clinica Universidad de Navarra - Pamplona, Pamplona

32003

Local Institution - 012-562-B, Fleming Island

32204

21st Century Oncology of Jacksonville - North Lee Street, Jacksonville

Local Institution - 012-562-D, Jacksonville

32207

Local Institution - 012-562-E, Jacksonville

32256

Local Institution - 012-562-A, Jacksonville

Local Institution - 012-562-C, Jacksonville

Local Institution - 012-562-F, Jacksonville

Local Institution - 012-562-G, Jacksonville

Local Institution - 012-562, Jacksonville

32503

USOR - Woodlands Medical Specialists, Pensacola

32806

Orlando Health University of Florida Health Cancer Center - Head and Neck Center, Orlando

33081

Local Institution - 012-274, Aviano

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

33308

Holy Cross Health Fort Lauderdale - Holy Cross Hospital, Fort Lauderdale

33322

Local Institution - 012-839, Plantation

34090

Hopital Arnaud de Villeneuve, Montpellier

34125

Klinikum Kassel, Kassel

35016

Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria

35392

Local Institution - 012-671, Giessen

37044

Hopital Bretonneau, Tours

37126

Local Institution - 012-758, Verona

38333

Anassa General Clinic, Volos

38700

Hopital Michallon, La Tronche

39008

Local Institution - 012-604, Santander

40503

Baptist Health Lexington, Lexington

41013

Local Institution - 012-629, Seville

41110

Local Institution - 012-235, Larissa

41404

Local Institution - 012-110, Daegu

42601

Local Institution - 012-523, Daegu

43126

Local Institution - 012-272, Parma

44106

University Hospitals Cleveland Medical Center, Cleveland

44805

Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau, Saint-Herblain

45136

Local Institution - 012-210, Essen

45429

Kettering Health Cancer Center - Main Campus, Kettering

46014

Consorci Hospital General Universitari de Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46158

Local Institution - 012-569 - A, Mooresville

46237

Local Institution - 012-569, Indianapolis

46321

Franciscan Health Munster, Munster

46526

Goshen Center for Cancer Care, Goshen

47014

"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST", Meldola

47905

Local Institution - 012-569 - B, Lafayette

Local Institution - 012-569 - C, Lafayette

48075

Ascension Providence Cancer Center - Southfield, Southfield

Local Institution - 012-974-A, Southfield

48108

Local Institution - 012-111, Busan

48121

Local Institution - 012-767, Ravenna

48374

Local Institution - 012-974-B, Novi

Local Institution - 012-974-C, Novi

48903

Local Institution - 012-776, Barakaldo

49241

Local Institution - 012-522, Busan

50009

Local Institution - 012-603, Zaragoza

50134

Local Institution - 012-762, Florence

51109

Klinikum Koln-Merheim, Cologne

53127

Universitatsklinikum Bonn, Bonn

54622

BioClinic Thessaloniki, Thessaloniki

57001

Local Institution - 012-230, Thessaloniki

57010

Local Institution - 012-500, Thessaloniki

57105

Avera Cancer Institute, Sioux Falls

58128

Local Institution - 012-100, Hwasun-gun

59037

Centre Hospitalier Regional Universitaire de Lille, Lille

59101

Local Institution - 012-841 - A, Billings

St. Vincent Healthcare Cancer Centers of Montana, Billings

59102

Sisters of Charity of Leavenworth Health St. Marys, Billings

60426

Local Institution - 012-972 C, Harvey

60451

Local Institution - 012-972 A, New Lenox

60462

Local Institution - 012-972 B, Orland Park

60612

University of Illinois Hospital & Health Sciences System, Chicago

60637

University of Chicago, Chicago

60714

Illinois Cancer Specialists - Niles, Niles

61122

Local Institution - 012-766, Pesaro

63069

Local Institution - 012-672, Offenbach

65613

Central Care Cancer Center - Bolivar, Bolivar

66205

Local Institution - 012-820, Westwood

66720

Local Institution - 012-942-B, Chanute

67042

Local Institution - 012-942-D, El Dorado

67068

Local Institution - 012-942-F, Kingman

67091

Hopital Civil, Strasbourg

67114

Local Institution - 012-942-I, Newton

67124

Local Institution - 012-942-K, Pratt

67152

Local Institution - 012-942-M, Wellington

67156

Local Institution - 012-942-N, Winfield

67200

Local Institution - 012-197, Strasbourg

67208

Local Institution - 012-942-A, Wichita

67214

Local Institution - 012-942, Wichita

67301

Local Institution - 012-942-E, Independence

67357

Local Institution - 012-942-J, Parsons

67401

Local Institution - 012-942-L, Salina

67460

Local Institution - 012-942-H, McPherson

67801

Local Institution - 012-942-C, Dodge City

67901

Local Institution - 012-942-G, Liberal

68100

Hopital Emile Muller, Mulhouse

69004

Local Institution - 012-191-B, Lyon

69400

LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone, Gleizé

69495

Local Institution - 012-191-A, Pierre-Bénite

69500

Hopital Louis Pradel, Bron

70112

Local Institution - 012-911 A, New Orleans

Tulane University, New Orleans

70124

Local Institution - 012-275, Bari

71110

University General Hospital of Heraklion (PAGNI), Heraklion

73100

Local Institution - 012-279, Lecce

74245

Local Institution - 012-224, Löwenstein

75063

US Oncology Research (USOR), Irving

75090

Texas Oncology - Sherman, Sherman

76012

Texas Oncology - Dallas Fort Worth (DFW) - Arlington Cancer Center North, Arlington

78745

Texas Oncology - Dallas Fort Worth (DFW) - South Austin, Austin

80026

SCL Health - Saint Joseph Hospital Cancer Center, Lafayette

80124

Local Institution - 012-872, Lone Tree

80131

Local Institution - 012-271, Napoli

Local Institution - 012-277, Napoli

80218

Local Institution - 012-951-B, Denver

81925

Local Institution - 012-220, München

82131

Local Institution - 012-214, Gauting

83100

Local Institution - 012-292, Avellino

84106

Utah Cancer Specialists - UCS Cancer Center, Salt Lake City

84124

Local Institution - 012-976-A, Salt Lake City

Local Institution - 012-976-B, Salt Lake City

Local Institution - 012-976-C, Salt Lake City

Local Institution - 012-976-D, Salt Lake City

Local Institution - 012-976-E, Salt Lake City

Local Institution - 012-976-F, Salt Lake City

Local Institution - 012-976-G, Salt Lake City

Local Institution - 012-976-H, Salt Lake City

Local Institution - 012-976-I, Salt Lake City

87042

Centre Hospitalier Universitaire Dupuytren 1, Limoges

90505

Local Institution - 012-910-E, Torrance

90703

Local Institution - 012-898, Cerritos

90808

City Of Hope, Long Beach

90813

Local Institution - 012-910-F, Long Beach

91010

City of Hope - Duarte (Main Campus), Duarte

91204

Local Institution - 012-898 D, Glendale

92618

Local Institution - 012-910-C, Irvine

92648

Local Institution - 012-910-A, Huntington Beach

92663

Local Institution - 012-910-D, Newport Beach

92705

Local Institution - 012-898 C, Santa Ana

94000

Centre Hospitalier Intercommunal de Creteil, Créteil

94805

Gustave Roussy, Villejuif

95122

Local Institution - 012-284, Catania

95123

Local Institution - 012-282, Catania

95403

Providence Medical Group - Santa Rosa, Santa Rosa

97301

Oregon Oncology Specialists, Salem

99437

Local Institution - 012-219, Bad Berka

121309

VitaMed - Moscow, Moscow

121467

University Headache Clinic, Moscow

168583

Local Institution - 012-093, Singapore

188770

Raffles Hospital, Singapore

197022

Local Institution - 012-355, Saint Petersburg

197376

"Federal State Budgetary Institution Influenza Research Institute named after N.N. A.A. Smorodintsev of the Ministry of Health", Saint Petersburg

197758

Local Institution - 012-354, Saint Petersburg

200385

Oncolab Craiova, Craiova

200746

Local Institution - 012-343, Craiova

217562

Icon Cancer Centre Farrer Park, Singapore

258499

Oncocare Cancer Centre, Singapore

258500

Parkway Cancer Centre - Gleneagles Hospital, Singapore

300166

Oncocenter - Oncologie Clinica, Timișoara

300239

SC OncoMed SRL, Timișoara

305524

"Regional Budgetary Healthcare Institution G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center of the Healthcare C", Kislino Village

400015

Local Institution - 012-344, Cluj-Napoca

400641

Local Institution - 012-340, Cluj-Napoca

426067

"Budgetary Healthcare Institution of the Udmurt Republic Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr", Izhevsk

430031

Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare, Baia Mare

454048

Evimed Oncology Clinic, Chelyabinsk

500152

SC Policlinica de Diagnostic Rapid SA, Brasov

602702

Local Institution - 012-101, Busan

603006

State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center, Nizhny Novgorod

630099

"Limited Liability Company Medical Sanitary Unit Clinicist-Clinic Pretor", Novosibirsk

644013

"Budgetary Healthcare Institution of Omsk region Clinical Oncologic Dispensary", Omsk

700106

Local Institution - 012-513, Iași

905900

Ovidius Clinical Hospital, Ovidiu

80033-6005

Local Institution - 012-951-A, Wheat Ridge

04043

Local Institution - 012-954 - A, Kennebunk

04074

New England Cancer Specialists - Scarborough, Scarborough

04086

Local Institution - 012-954 - B, Topsham

08816

Astera Cancer Care - East Brunswick, East Brunswick

08820

Local Institution - 012-975 - A, Edison

08831

Local Institution - 012-975 - B, Monroe

08873

Local Institution - 012-975 - C, Somerset

08876

Local Institution - 012-975 - D, Somerville

07666

Holy Name Medical Center, Teaneck

13210-2306

SUNY Upstate Medical University, Syracuse

02903

Lifespan Cancer Institute - Rhode Island Hospital, Providence

02906

Local Institution - 012-960-A, Providence

22908-0674

UVA Health - University Hospital, Charlottesville

B-5530

Local Institution - 012-150, Yvoir

268 31

Local Institution - 012-164, Hořovice

779 00

Local Institution - 012-162, Olomouc

128 08

Vseobecna Fakultni Nemocnice v Praze, Prague

180 81

Fakultni nemocnice Bulovka, Praha 8 - Liben

06189

Local Institution - 012-685, Nice

06120

Local Institution - 012-215, Halle

07747

Universitatsklinikum Jena, Jena

145 64

"General Oncology Hospital of Kifisias Agioi Anargyroi", Nea Kifissia

185 47

Local Institution - 012-234, Piraeus

Metropolitan Hospital, Piraeus

D24 NR04

The Meath Foundation, Tallaght

D08 NHY1

St. Jamess Hospital, Dublin

H91 YR71

University Hospital Galway, Galway

V94 F858

University Hospital Limerick, Limerick

06132

Local Institution - 012-281, Perugia

00144

Local Institution - 012-295, Roma

1081 HV

Local Institution - 012-306, Amsterdam

4818 CK

Amphia Ziekenhuis - Breda Molengracht, Breda

6229 HX

Local Institution - 012-300, Maastricht

6525 GA

Local Institution - 012-630, Nijmegen

2545 AA

Local Institution - 012-308, The Hague

3543 AZ

Local Institution - 012-307, Utrecht

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

90-302

Instytut MSF, Lodz

20-064

Local Institution - 012-321, Lublin

20-093

Local Institution - 012-760, Lublin

05-400

Local Institution - 012-325, Otwock

35-922

Local Institution - 012-320, Rzeszów

60-185

Local Institution - 012-324, Skorzewo

87-100

Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu, Torun

02-781

Local Institution - 012-322, Warsaw

04-349

Wojskowy Instytut Medyczny, Warsaw

2805-267

Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta), Almada

4710-243

Unidade Local de Saude de Braga, E. P. E (Hospital de Braga), Braga

3000-075

Local Institution - 012-330, Coimbra

Local Institution - 012-645, Coimbra

4835-044

Local Institution - 012-333, Guimarães

1099-023

Local Institution - 012-642, Lisbon

1350-352

Local Institution - 012-338-A, Lisbon

1400-038

The Champalimaud Centre for the Unknown, Lisbon

1998-018

Local Institution - 012-338, Lisbon

2674-514

Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo), Loures

4099-001

Local Institution - 012-331, Porto

4200-072

Local Institution - 012-339, Porto

4520-211

Unidade Local de Saude de Entre Douro e Vouga, E. P. E, Santa Maria da Feira

2910-443

Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal), Setúbal

4434-502

Unidade Local de Saude de Gaia/Espinho, E. P. E, Vila Nova de Gaia

00919

Puerto Rico Medical Research Center, San Juan

00927

FDI Clinical Research (Fundacion de Investigacion de Diego) - San Juan, San Juan

00935

PanOncology Trials - Rio Piedras Medical Center, San Juan

010991

Centrul Oncologic Sanador, Bucharest

022328

Local Institution - 012-342, Bucharest

400-712

Local Institution - 012-102, Junggu

02841

Korea University Anam Hospital, Seoul

03722

Local Institution - 012-118, Seoul

05080

Local Institution - 012-106, Seoul

05505

Asan Medical Center, Seoul

06591

The Catholic University of Korea - Seoul St. Marys Hospital, Seoul

08916

Hospital Germans Trias i Pujol, Badalona

08003

Hospital del Mar - Parc de Salut Mar, Barcelona

08028

Local Institution - 012-614, Barcelona

08035

Local Institution - 012-612, Barcelona

08036

Local Institution - 012-600, Barcelona

07120

Local Institution - 012-602, Palma de Mallorca

B9 5SS

University Hospitals Birmingham NHS Foundation Trust, Birmingham

EH4 2XU

NHS Lothian, Edinburgh

G12 0XH

NHS Greater Glasgow and Clyde, Glasgow

LE1 5WW

University Hospitals of Leicester NHS Trust, Leicester

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY

NCT04685135 - Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation | Biotech Hunter | Biotech Hunter