KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

270

Participants

Timeline

Start Date

October 18, 2023

Primary Completion Date

January 31, 2027

Study Completion Date

April 30, 2027

Conditions
Solid Tumors With HRAS AlterationsNon Small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma (PDAC)Clear Cell Renal Cell Carcinoma (ccRCC)Renal Cell Carcinoma (Kidney Cancer)
Interventions
DRUG

Darlifarnib

Oral administration

DRUG

Cabozantinib

Oral administration

DRUG

Adagrasib

Oral administration

Trial Locations (32)

10060

RECRUITING

Fondazione Piemonte per l'Oncologia - IRCCs Candiolo, Candiolo

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

20089

RECRUITING

Camplus Humanitas University, Rozzano

28050

RECRUITING

Hospital HM Sanchinarro START Madrid-CIOCC, Madrid

31059

RECRUITING

Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse

32224

RECRUITING

Mayo Clinic Comprehensive Cancer Center, Jacksonville

34232

RECRUITING

Florida Cancer Specialists, Sarasota

34747

RECRUITING

AdventHealth Celebration, Celebration

37134

RECRUITING

AOU Verona - Centro Ricerche Cliniche di Verona, Verona

37203

RECRUITING

SCRI - Oncology Partners, Nashville

40138

RECRUITING

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS, Bologna

41013

RECRUITING

Hospital Universitario Virgen del Rocío, Seville

48202

RECRUITING

Henry Ford Health System, Detroit

52242

RECRUITING

University of Iowa Hospitals & Clinics, Iowa City

53792

RECRUITING

University of Wisconsin (Carbone Cancer Center), Madison

55905

RECRUITING

Mayo Clinic Comprehensive Cancer Center, Rochester

63110

RECRUITING

Washington University School of Medicine, St Louis

73104

RECRUITING

OU Stephenson Cancer Center, Oklahoma City

75013

RECRUITING

Oncologie médicale - Pitié-Salpêtrière, Paris

75015

RECRUITING

Hopital Européen Georges Pompidou, Paris

75235

RECRUITING

UT Southwestern Simmons Cancer Center, Dallas

77030

RECRUITING

MD Anderson Cancer Center, Houston

80131

RECRUITING

Istituto Nazionale Tumori IRCCS, Napoli

80218

RECRUITING

Sarah Cannon Research Institute at HealthONE, Denver

85054

RECRUITING

Mayo Clinic Comprehensive Cancer Center, Phoenix

90033

RECRUITING

University of Southern California, Los Angeles

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

90095

RECRUITING

UCLA Department of Medicine, Los Angeles

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

08901

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

08041

RECRUITING

Hospital de la Santa Creu i de Sant Pau, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mirati Therapeutics Inc.

INDUSTRY

lead

Kura Oncology, Inc.

INDUSTRY