National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

423

Participants

Timeline

Start Date

May 31, 2015

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Non-Small Cell Lung CancerCarcinoma, Squamous CellAdenocarcinoma
Interventions
DRUG

AZD4547

FGFR Inhibitor

DRUG

Vistusertib

MTORC1/2 Inhibitor

DRUG

Palbociclib

CDK4/6 Inhibitor

DRUG

Crizotinib

ALK/MET/ROS1 Inhibitor

DRUG

Selumetinib

MEK Inhibitor

DRUG

Docetaxel

Taxane, anti-mitotic cytotoxic chemotherapy

DRUG

AZD5363

AKT Inhibitor

DRUG

Osimertinib

EGFRm+ T790M+ Inhibitor

DRUG

Durvalumab

Anti-PDL1

DRUG

Sitravatinib

VEGFR Inhibitor

DRUG

AZD6738

ATR inhibitor

Trial Locations (25)

Unknown

Aberdeen Royal Infirmary, Aberdeen

Belfast City Hospital, Belfast Health and Social Care Trust, Belfast

Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham

University Hospitals Bristol NHS Foundation Trust, Bristol

Colchester General Hospital, Colchester

Royal Devon and Exeter Hospital, Exeter

Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester

Charing Cross Hospital, Imperial College Healthcare NHS Trust, London

Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London

St Bartholomew's Hospital, Barts Health NHS Trust, London

University College Hospital, University College London Hospitals NHS Foundation Trust, London

Maidstone Hospital, Maidstone

The Christie Hospital, The Christie NHS Foundation Trust, Manchester

Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford

Weston Park Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

B15 2GW

Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham

CB2 0QQ

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge

CF14 2TL

Velindre Cancer Centre, Velindre NHS Trust, Cardiff

EH4 2XU

Edinburgh Cancer Centre, Western General Hospital, Edinburgh

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

LS9 7TF

St. James' University Hospital, Leeds Teaching Hospital NHS Trust, Leeds

SW3 6JJ

Royal Marsden Hospital, The Royal Marsden NHS Foundation Trust, London

CH63 4JY

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

NE7 7DN

Sir Bobby Robson Cancer Trial Research Centre, The Newcastle upon Tyne Hospitals, Newcastle

SO16 6YD

Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton

All Listed Sponsors
collaborator

Cancer Research UK

OTHER

collaborator

AstraZeneca

INDUSTRY

collaborator

Pfizer

INDUSTRY

collaborator

Experimental Cancer Medicine Centres

OTHER

collaborator

Mirati Therapeutics Inc.

INDUSTRY

lead

University of Birmingham

OTHER