423
Participants
Start Date
May 31, 2015
Primary Completion Date
September 30, 2025
Study Completion Date
September 30, 2025
AZD4547
FGFR Inhibitor
Vistusertib
MTORC1/2 Inhibitor
Palbociclib
CDK4/6 Inhibitor
Crizotinib
ALK/MET/ROS1 Inhibitor
Selumetinib
MEK Inhibitor
Docetaxel
Taxane, anti-mitotic cytotoxic chemotherapy
AZD5363
AKT Inhibitor
Osimertinib
EGFRm+ T790M+ Inhibitor
Durvalumab
Anti-PDL1
Sitravatinib
VEGFR Inhibitor
AZD6738
ATR inhibitor
Aberdeen Royal Infirmary, Aberdeen
Belfast City Hospital, Belfast Health and Social Care Trust, Belfast
Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham
University Hospitals Bristol NHS Foundation Trust, Bristol
Colchester General Hospital, Colchester
Royal Devon and Exeter Hospital, Exeter
Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester
Charing Cross Hospital, Imperial College Healthcare NHS Trust, London
Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London
St Bartholomew's Hospital, Barts Health NHS Trust, London
University College Hospital, University College London Hospitals NHS Foundation Trust, London
Maidstone Hospital, Maidstone
The Christie Hospital, The Christie NHS Foundation Trust, Manchester
Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford
Weston Park Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge
Velindre Cancer Centre, Velindre NHS Trust, Cardiff
Edinburgh Cancer Centre, Western General Hospital, Edinburgh
Beatson West of Scotland Cancer Centre, Glasgow
St. James' University Hospital, Leeds Teaching Hospital NHS Trust, Leeds
Royal Marsden Hospital, The Royal Marsden NHS Foundation Trust, London
Clatterbridge Cancer Centre, Metropolitan Borough of Wirral
Sir Bobby Robson Cancer Trial Research Centre, The Newcastle upon Tyne Hospitals, Newcastle
Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton
Collaborators (4)
Cancer Research UK
OTHER
AstraZeneca
INDUSTRY
Pfizer
INDUSTRY
Experimental Cancer Medicine Centres
OTHER
Mirati Therapeutics Inc.
INDUSTRY
University of Birmingham
OTHER