Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 22, 2022

Primary Completion Date

June 1, 2026

Study Completion Date

December 1, 2026

Conditions
Advanced NSCLCMetastatic Lung Cancer
Interventions
DRUG

Adagrasib oral dose of 400 mg twice daily tablets

oral dose of 400 mg twice daily tablets

COMBINATION_PRODUCT

Pembrolizumab

IV infusion once every 3 weeks

COMBINATION_PRODUCT

Chemotherapy: Pemetrexed

IV infusion once every 3 weeks

COMBINATION_PRODUCT

Cisplatin/Carboplatin

IV infusion once every 3 weeks

Trial Locations (166)

0

WITHDRAWN

Local Institution - 017-696, Santiago

1121

RECRUITING

Orszagos Koranyi Pulmonologiai Intezet, Budapest

1122

RECRUITING

Orszagos Onkologiai Intezet, Budapest

1205

WITHDRAWN

Local Institution - 017-395, Geneva

2045

RECRUITING

Reformatus Pulmonologiai Centrum, Törökbálint

6000

WITHDRAWN

Local Institution - 017-790, Batumi

8000

RECRUITING

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

10028

NOT_YET_RECRUITING

Local Institution - 017-085, New York

10043

RECRUITING

Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano

10400

WITHDRAWN

Local Institution - 017-136, Bangkok

10467

WITHDRAWN

Local Institution - 017-945, The Bronx

10469

NOT_YET_RECRUITING

Local Institution - 017-083, The Bronx

10700

WITHDRAWN

Local Institution - 017-132, Bang Phlat

11000

WITHDRAWN

Local Institution - 017-692, Belgrade

WITHDRAWN

Local Institution - 017-693, Belgrade

11042

NOT_YET_RECRUITING

Local Institution - 017-087, New Hyde Park

11080

WITHDRAWN

Local Institution - 017-690, Belgrade

11210

NOT_YET_RECRUITING

Local Institution - 017-088, Brooklyn

11702

NOT_YET_RECRUITING

Local Institution - 017-080, Babylon

11772

NOT_YET_RECRUITING

Local Institution - 017-082, Patchogue

11776

NOT_YET_RECRUITING

Local Institution - 017-086, Port Jefferson

NOT_YET_RECRUITING

Local Institution - 017-081, Port Jefferson Station

RECRUITING

New York Cancer & Blood Specialists - Cancer Center - Research Headquarters, Port Jefferson Station

11901

NOT_YET_RECRUITING

Local Institution - 017-084, Riverhead

13009

RECRUITING

Institut Paoli-Calmettes, Marseille

13015

ACTIVE_NOT_RECRUITING

Local Institution - Unk067, Marseille

13057

RECRUITING

Hematology-Oncology Associates of Central New York - Brittonfield - East Syracuse, East Syracuse

14076

RECRUITING

Centre Francois Baclesse, Caen

15006

RECRUITING

Complejo Hospitalario Universitario A Coruna, A Coruña

15033

RECRUITING

Ospedale Santo Spirito, Casale Monferrato

15586

WITHDRAWN

Local Institution - 017-076, Kota Bharu

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

20155

NOT_YET_RECRUITING

Local Institution - 017-814-B, Gainesville

20190

NOT_YET_RECRUITING

Local Institution - 017-814-C, Reston

21079

RECRUITING

Centre Georges Francois Leclerc, Dijon

21201

ACTIVE_NOT_RECRUITING

Local Institution - Unk009, Baltimore

21204

WITHDRAWN

Local Institution - 017-691, Kamenitz

22031

ACTIVE_NOT_RECRUITING

Local Institution - Unk066, Fairfax

RECRUITING

Virginia Cancer Specialists - Fairfax Office, Fairfax

22205

NOT_YET_RECRUITING

Local Institution - 017-814-A, Arlington

25100

WITHDRAWN

Local Institution - 017-075, Kuantan

25705

ACTIVE_NOT_RECRUITING

Local Institution - Unk036, Huntington

28007

RECRUITING

Hospital General Universitario Gregorio Maranon, Madrid

28046

RECRUITING

Hospital Universitario La Paz, Madrid

28222

RECRUITING

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

29010

ACTIVE_NOT_RECRUITING

Local Institution - Unk001, Málaga

31059

RECRUITING

Hopital Larrey, Toulouse

32224

RECRUITING

Mayo Clinic - Jacksonville, Jacksonville

32803

ACTIVE_NOT_RECRUITING

Local Institution - Unk055, Orlando

33081

NOT_YET_RECRUITING

Local Institution - 017-274, Aviano

33136

ACTIVE_NOT_RECRUITING

Local Institution - Unk076, Miami

33812

RECRUITING

The Oncology Institute of Hope and Innovation - Lakeland, Lakeland

34000

WITHDRAWN

Local Institution - 017-694, Kragujevac

34090

WITHDRAWN

Local Institution - 017-200, Montpellier

35128

WITHDRAWN

Local Institution - 017-297, Padua

38104

WITHDRAWN

Local Institution - 017-916, Memphis

38700

RECRUITING

Hopital Michallon, La Tronche

40002

WITHDRAWN

Local Institution - 017-137, Khon Kaen

40503

WITHDRAWN

Local Institution - 017-965, Lexington

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

41110

RECRUITING

University General Hospital of Larissa, Larissa

44195

RECRUITING

Cleveland Clinic Main Campus, Cleveland

44805

WITHDRAWN

Local Institution - 017-198, Saint-Herblain

45429

WITHDRAWN

Local Institution - 017-836, Kettering

48018

NOT_YET_RECRUITING

Local Institution - 017-767 - B, Faenza

48022

NOT_YET_RECRUITING

Local Institution - 017-767 - A, Lugo

48121

RECRUITING

Ospedale Santa Maria delle Croci di Ravenna, Ravenna

48201

ACTIVE_NOT_RECRUITING

Local Institution - Unk069, Detroit

48377

RECRUITING

Henry Ford Medical Center - Columbus, Novi

49055

RECRUITING

Institut de Cancerologie de lOuest - Angers, Angers

50009

RECRUITING

Hospital Clinico Universitario Lozano Blesa, Zaragoza

50134

RECRUITING

Azienda Ospedaliero - Universitaria Careggi, Florence

50200

WITHDRAWN

Local Institution - 017-135, Chom Thong

50586

WITHDRAWN

Local Institution - 017-073, Kuala Lumpur

55404

NOT_YET_RECRUITING

Local Institution - 017-838B, Minneapolis

NOT_YET_RECRUITING

Local Institution - 017-838C, Minneapolis

55416

RECRUITING

Metro-Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park

55905

RECRUITING

Mayo Clinic - Rochester, Rochester

59000

WITHDRAWN

Local Institution - 017-688, Lille

60612

ACTIVE_NOT_RECRUITING

Local Institution - Unk062, Chicago

60637

RECRUITING

University of Chicago, Chicago

62250

WITHDRAWN

Local Institution - 017-072, Putrajaya

64064

NOT_YET_RECRUITING

Local Institution - 017-820D, Lee's Summit

64116

NOT_YET_RECRUITING

Local Institution - 017-820F, Kansas City

NOT_YET_RECRUITING

Local Institution - 017-820G, North Kansas City

64154

NOT_YET_RECRUITING

Local Institution - 017-820E, Kansas City

65065

ACTIVE_NOT_RECRUITING

Local Institution - Unk008, Osage Beach

65807

ACTIVE_NOT_RECRUITING

Local Institution - Unk058, Springfield

66160

NOT_YET_RECRUITING

Local Institution - 017-820A, Kansas City

NOT_YET_RECRUITING

Local Institution - 017-820B, Kansas City

NOT_YET_RECRUITING

Local Institution - 017-820C, Kansas City

NOT_YET_RECRUITING

Local Institution - 017-820H, Kansas City

66205

NOT_YET_RECRUITING

Local Institution - 017-820J, Fairway

RECRUITING

University of Kansas Cancer Center - Westwood/Richard and Annette Bloch Cancer Care Pavilion, Westwood

66210

NOT_YET_RECRUITING

Local Institution - 017-820I, Overland Park

69008

ACTIVE_NOT_RECRUITING

Local Institution - Unk078, Lyon

71110

RECRUITING

University General Hospital of Heraklion (PAGNI), Heraklion

75018

ACTIVE_NOT_RECRUITING

Local Institution - Unk029, Paris

75020

RECRUITING

Hopital Tenon, Paris

75063

NOT_YET_RECRUITING

Local Institution - 017-999, Irving

75246

RECRUITING

Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center, Dallas

75248

WITHDRAWN

Local Institution - 017-664, Paris

75390

ACTIVE_NOT_RECRUITING

Local Institution - Unk056, Dallas

75460

NOT_YET_RECRUITING

Local Institution - 017-878-C, Paris

75601

RECRUITING

USOR - Texas Oncology Northeast Texas - Longview Cancer Center, Longview

75702

NOT_YET_RECRUITING

Local Institution - 017-878-A, Tyler

75801

NOT_YET_RECRUITING

Local Institution - 017-878-B, Palestine

77030

WITHDRAWN

Local Institution - 017-848, Houston

80012

NOT_YET_RECRUITING

Local Institution - 017-872-I, Aurora

80124

RECRUITING

USOR - Rocky Mountain Cancer Centers - Lone Tree - Sky Ridge Medical Center, Lone Tree

80218

NOT_YET_RECRUITING

Local Institution - 017-872-B, Denver

NOT_YET_RECRUITING

Local Institution - 017-872-C, Littleton

80220

NOT_YET_RECRUITING

Local Institution - 017-872-F, Denver

80228

NOT_YET_RECRUITING

Local Institution - 017-872-A, Lakewood

80260

NOT_YET_RECRUITING

Local Institution - 017-872-H, Thornton

80303

NOT_YET_RECRUITING

Local Institution - 017-872-G, Boulder

80907

NOT_YET_RECRUITING

Local Institution - 017-872-D, Colorado Springs

80920

NOT_YET_RECRUITING

Local Institution - 017-872-J, Colorado Springs

81003

NOT_YET_RECRUITING

Local Institution - 017-872-E, Pueblo

83100

RECRUITING

Azienda Ospedaliera San Giuseppe Moscati - Avellino, Avellino

84106

ACTIVE_NOT_RECRUITING

Local Institution - Unk010, Salt Lake City

85004

WITHDRAWN

Local Institution - 017-821, Phoenix

85304

WITHDRAWN

Local Institution - 017-591, Glendale

90095

WITHDRAWN

Local Institution - 017-961, Los Angeles

92150

RECRUITING

Hopital Foch, Suresnes

92354

ACTIVE_NOT_RECRUITING

Local Institution - Unk004, Loma Linda

92708

NOT_YET_RECRUITING

Local Institution - 017-936C, Fountain Valley

RECRUITING

MemorialCare - Orange Coast Medical Center, Fountain Valley

92805

ACTIVE_NOT_RECRUITING

Local Institution - Unk047, Anaheim

92835

RECRUITING

Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton, Fullerton

94000

RECRUITING

Centre Hospitalier Intercommunal de Creteil, Créteil

94158

RECRUITING

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94805

RECRUITING

Gustave Roussy, Villejuif

98225

RECRUITING

PeaceHealth St. Joseph Medical Center, Bellingham

99508

ACTIVE_NOT_RECRUITING

Local Institution - Unk025, Anchorage

380077

WITHDRAWN

Local Institution - 017-793, Tbilisi

488912

ACTIVE_NOT_RECRUITING

Local Institution - Unk018, Lansing

2520612

WITHDRAWN

Local Institution - 017-695, Viña del Mar

4810469

WITHDRAWN

Local Institution - 017-698, Temuco

7500006

WITHDRAWN

Local Institution - 017-697, Providencia

02115

RECRUITING

Beth Israel Deaconess Medical Center, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

01803

ACTIVE_NOT_RECRUITING

Local Institution - Unk039, Burlington

55426-5000

NOT_YET_RECRUITING

Local Institution - 017-838A, Saint Louis Park

59062-000

WITHDRAWN

Local Institution - 017-458, Natal

98700-000

WITHDRAWN

Local Institution - 017-446, Ijuí

88301-220

WITHDRAWN

Local Institution - 017-453, Itajaí

14784-400

WITHDRAWN

Local Institution - 017-457, Barretos

81520-060

WITHDRAWN

Local Institution - 017-442, Curitiba

60810-180

WITHDRAWN

Local Institution - 017-452, Fortaleza

17210-180

WITHDRAWN

Local Institution - 017-455, Jaú

22250-905

WITHDRAWN

Local Institution - 017-454, Rio de Janeiro

01246-000

WITHDRAWN

Local Institution - 017-456, São Paulo

0144

WITHDRAWN

Local Institution - 017-789, Tbilisi

0159

WITHDRAWN

Local Institution - 017-794, Tbilisi

0177

WITHDRAWN

Local Institution - 017-791, Tbilisi

0259

WITHDRAWN

Local Institution - 017-792, Tbilisi

185 47

RECRUITING

Metropolitan Hospital, Piraeus

00144

RECRUITING

IRCCS Istituto Nazionale Tumori Regina Elena, Roma

00168

ACTIVE_NOT_RECRUITING

Local Institution - 017-280, Roma

62-500

WITHDRAWN

Local Institution - 017-381, Konin

90-302

RECRUITING

Instytut MSF, Lodz

60-693

RECRUITING

Med Polonia Sp. z o. o. - Obornicka, Poznan

04-349

RECRUITING

Wojskowy Instytut Medyczny, Warsaw

07120

RECRUITING

Hospital Universitario Son Espases, Palma de Mallorca

07198

RECRUITING

Hospital Son Llatzer, Palma de Mallorca

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY

NCT05609578 - Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation | Biotech Hunter | Biotech Hunter