Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

731

Participants

Timeline

Start Date

January 15, 2019

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Advanced CancerMetastatic CancerMalignant Neoplastic Disease
Interventions
DRUG

MRTX849

MRTX849 will be administered orally once or twice daily in a continuous regimen

DRUG

Pembrolizumab

Pembrolizumab is administered as an intravenous infusion once every 3 weeks

DRUG

Cetuximab

Cetuximab will be administered as an intravenous infusion once per week or once every 2 weeks

DRUG

Afatinib

Afatinib will be administered orally once a day in a continuous regimen

Trial Locations (222)

10016

Local Institution - 001-813, New York

10065

Local Institution - 001-806, New York

12206

Local Institution - 001-861, Albany

14203

Local Institution - 001-815, Buffalo

18017

Local Institution - 001-837-A, Bethlehem

18103

Local Institution - 001-837, Allentown

19063

Local Institution - 001-783, Media

20613

Local Institution - 001-881-B, Brandywine

20904

Local Institution - 001-881-A, Silver Spring

21044

Local Institution - 001-881, Columbia

22031

Local Institution - 001-814, Fairfax

23229

Local Institution - 001-968, Richmond

23502

Local Institution - 001-882-A, Norfolk

Local Institution - 001-890-A, Norfolk

23606

Local Institution - 001-882, Newport News

24408

Local Institution - 001-597, Fredericksburg

27514

Local Institution - 001-812, Chapel Hill

28374

Local Institution - 001-971, Pinehurst

29414

Local Institution - 001-887, Charleston

29425

Local Institution - 001-819, Charleston

30060

Local Institution - 001-835, Marietta

30106

Local Institution - 001-835-C, Austell

Local Institution - 001-835-E, Austell

30117

Local Institution - 001-835-D, Carrollton

Local Institution - 001-835-F, Carrollton

30121

Local Institution - 001-835-A, Cartersville

30134

Local Institution - 001-835-B, Douglasville

30607

Local Institution - 001-967, Athens

32117

Local Institution - 001-926b, Daytona Beach

32159

Local Institution - 001-929m, Lady Lake

32224

Local Institution - 001-829, Jacksonville

32503

Local Institution - 001-877, Pensacola

32605

Local Institution - 001-929b, Gainesville

32701

Local Institution - 001-929i, Altamonte Springs

32763

Local Institution - 001-914, Orange City

Local Institution - 001-929j, Orange City

32778

Local Institution - 001-929k, Tavares

32789

Local Institution - 001-929o, Winter Park

32806

Local Institution - 001-929l, Orlando

32960

Local Institution - 001-926c, Vero Beach

33140

Local Institution - 001-825, Miami Beach

33176

Local Institution - 001-870, Miami

33401

Local Institution - 001-926, West Palm Beach

33414

Local Institution - 001-926a, Wellington

33432

Local Institution - 001-839, Boca Raton

33511

Local Institution - 001-929c, Brandon

33607

Local Institution - 001-929d, Tampa

33705

Local Institution - 001-929a, St. Petersburg

Local Institution - 001-929, St. Petersburg

33761

Local Institution - 001-929g, Clearwater

33770

Local Institution - 001-929e, Largo

33901

Local Institution - 001-922, Fort Myers

33905

Local Institution - 001-922B, Fort Myers

33908

Local Institution - 001-922C, Fort Myers

33909

Local Institution - 001-922E, Cape Coral

33980

Local Institution - 001-922H, Port Charlotte

34102

Local Institution - 001-922F, Naples

Local Institution - 001-922G, Naples

34135

Local Institution - 001-922A, Bonita Springs

34211

Local Institution - 001-922D, Bradenton

34232

Local Institution - 001-922I, Sarasota

34236

Local Institution - 001-922J, Sarasota

34285

Local Institution - 001-922K, Venice

34292

Local Institution - 001-922L, Venice

34461

Local Institution - 001-929n, Lecanto

34474

Local Institution - 001-538, Ocala

Local Institution - 001-929p, Ocala

34608

Local Institution - 001-929h, Spring Hill

34655

Local Institution - 001-929f, Trinity

34994

Local Institution - 001-926d, Stuart

35294

Local Institution - 001-826, Birmingham

37066

Local Institution - 001-801-G, Gallatin

37075

Local Institution - 001-801-A, Hendersonville

37076

Local Institution - 001-801-D, Hermitage

37129

Local Institution - 001-801-F, Murfreesboro

37203

Local Institution - 001-801-B, Nashville

Local Institution - 001-801, Nashville

37207

Local Institution - 001-801-E, Nashville

37211

Local Institution - 001-801-C, Nashville

40536

Local Institution - 001-844, Lexington

43201

Local Institution - 001-833 - H, Columbus

43203

Local Institution - 001-833 - C, Columbus

Local Institution - 001-833 - J, Columbus

43210

Local Institution - 001-833 - A, Columbus

Local Institution - 001-833 - F, Columbus

Local Institution - 001-833, Columbus

43212

Local Institution - 001-833 - D, Columbus

Local Institution - 001-833 - I, Columbus

43219

Local Institution - 001-930, Columbus

43221

Local Institution - 001-833 - B, Columbus

Local Institution - 001-833 - G, Columbus

43230

Local Institution - 001-833 - E, Gahanna

44195

Local Institution - 001-818, Cleveland

45219

Local Institution - 001-966, Cincinnati

45267

Local Institution - 001-823, Cincinnati

45429

Local Institution - 001-836-A, Kettering

Local Institution - 001-836, Kettering

46601

Local Institution - 001-781, South Bend

48201

Local Institution - 001-842, Detroit

48202

Local Institution - 001-811, Detroit

48334

Local Institution - 001-842-A, Farmington Hills

52242

Local Institution - 001-831, Iowa City

53792

Local Institution - 001-804, Madison

55101

Local Institution - 001-838-A, Saint Paul

55102

Local Institution - 001-875 - B, Saint Paul

55109

Local Institution - 001-838-D, Maplewood

Local Institution - 001-875 - A, Maplewood

55125

Local Institution - 001-875 - C, Woodbury

55404

Local Institution - 001-838-C, Minneapolis

Local Institution - 001-875, Minneapolis

55415

Local Institution - 001-838-G, Minneapolis

55416

Local Institution - 001-838, Saint Louis Park

55433

Local Institution - 001-838-F, Coon Rapids

55435

Local Institution - 001-838-E, Edina

Local Institution - 001-875 - D, Edina

55455

Local Institution - 001-822-A, Minneapolis

Local Institution - 001-822, Minneapolis

55905

Local Institution - 001-830, Rochester

59102

Local Institution - 001-841, Billings

60415

Local Institution - 001-862, Chicago Ridge

60714

Local Institution - 001-883, Niles

65109

Local Institution - 001-950, Jefferson City

65613

Local Institution - 001-952, Bolivar

66205

Local Institution - 001-820, Westwood

68114

Local Institution - 001-959, Omaha

68118

Local Institution - 001-544A, Omaha

68198

Local Institution - 001-544, Omaha

70809

Local Institution - 001-920, Baton Rouge

73505

Local Institution - 001-600, Lawton

74146

Local Institution - 001-584, Tulsa

75020

Local Institution - 001-785, Denison

75063

Local Institution - 001-999, Irving

75230

Local Institution - 001-809, Dallas

75231

Local Institution - 001-886, Dallas

75246

Local Institution - 001-879, Dallas

75702

Local Institution - 001-878, Tyler

76012

Local Institution - 001-888-B, Arlington

Local Institution - 001-888, Arlington

76104

Local Institution - 001-876, Fort Worth

76712

Local Institution - 001-890, Waco

77030

Local Institution - 001-848, Houston

Local Institution - 001-969, Houston

77090

Local Institution - 001-935A, Houston

77339

Local Institution - 001-935D, Kingwood

Local Institution - 001-935, Kingwood

77375

Local Institution - 001-935E, Tomball

77380

Local Institution - 001-935B, Shenandoah

77384

Local Institution - 001-848a, Conroe

77389

Local Institution - 001-935C, Spring

77479

Local Institution - 001-874, Sugar Land

78229

Local Institution - 001-802, San Antonio

78731

Local Institution - 001-880, Austin

79701

Local Institution - 001-554, Midland

80012

Local Institution - 001-872, Aurora

80026

Local Institution - 001-951, Lafayette

80045

Local Institution - 001-810, Aurora

80124

Local Institution - 001-872-K, Lone Tree

80138

Local Institution - 001-872-J, Parker

80218

Local Institution - 001-872-B, Denver

Local Institution - 001-951 - A, Denver

Local Institution - 001-951 - B, Denver

Local Institution - 001-872-D, Littleton

80228

Local Institution - 001-872-A, Lakewood

80260

Local Institution - 001-872-I, Thornton

80303

Local Institution - 001-872-H, Boulder

80501

Local Institution - 001-872-C, Longmont

80907

Local Institution - 001-872-E, Colorado Springs

80920

Local Institution - 001-872-L, Colorado Springs

81008

Local Institution - 001-872-F, Pueblo

Local Institution - 001-872-G, Pueblo

81501

Local Institution - 001-846, Grand Junction

85054

Local Institution - 001-821, Phoenix

85704

Local Institution - 001-873-A, Tucson

Local Institution - 001-873, Tucson

89052

Local Institution - 001-860A, Henderson

Local Institution - 001-860C, Henderson

89074

Local Institution - 001-860B, Henderson

Local Institution - 001-860, Henderson

89128

Local Institution - 001-860E, Las Vegas

89144

Local Institution - 001-860D, Las Vegas

89148

Local Institution - 001-860F, Las Vegas

90027

Local Institution - 001-840, Los Angeles

90067

Local Institution - 001-578, Los Angeles

90211

Local Institution - 001-834, Beverly Hills

90706

Local Institution - 001-840-B, Bellflower

90710

Local Institution - 001-840-C, Harbor City

90720

Local Institution - 001-779, Los Alamitos

91010

Local Institution - 001-843, Duarte

92093

Local Institution - 001-805, La Jolla

92111

Local Institution - 001-845, San Diego

92120

Local Institution - 001-840-A, San Diego

92663

Local Institution - 001-847, Newport Beach

92835

Local Institution - 001-851, Fullerton

92868

Local Institution - 001-803, Orange

93105

Local Institution - 001-884, Santa Barbara

93463

Local Institution - 001-884-A, Solvang

94080

Local Institution - 001-850-H, San Francisco

94115

Local Institution - 001-850-E, San Francisco

94568

Local Institution - 001-850-K, Dublin

94577

Local Institution - 001-850-A, San Leandro

94589

Local Institution - 001-850, Vallejo

94596

Local Institution - 001-850-G, Walnut Creek

94611

Local Institution - 001-850-B, Oakland

95051

Local Institution - 001-850-I, Santa Clara

95119

Local Institution - 001-850-F, San Jose

95661

Local Institution - 001-850-C, Roseville

95814

Local Institution - 001-850-J, Sacramento

95825

Local Institution - 001-850-D, Sacramento

97401

Local Institution - 001-889, Eugene

97701

Local Institution - 001-586-A, Bend

Local Institution - 001-586, Bend

98109

Local Institution - 001-824, Seattle

98684

Local Institution - 001-885, Vancouver

99508

Local Institution - 001-965, Anchorage

06510

Local Institution - 001-816, New Haven

19713-2055

Local Institution - 001-871, Newark

04005

Local Institution - 001-827, Biddeford

02215

Local Institution - 001-808, Boston

55426-5000

Local Institution - 001-838-B, Saint Louis Park

68105-1850

Local Institution - 001-544B, Omaha

17033-0850

Local Institution - 001-817, Hershey

00935

Local Institution - 001-900, San Juan

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY