Small Molecules
Total Trials
46
As Lead Sponsor
41
As Collaborator
5
Total Enrollment
17,892
NCT01380223
A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers
Phase: Phase 1
Role: Lead Sponsor
Start: Aug 31, 2005
Completion: Apr 30, 2006
NCT00343564
A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma
Phase: Phase 1/2
Start: Apr 30, 2006
Completion: Jul 31, 2010
NCT00624442
A Study of CK-1827452 Infusion in Stable Heart Failure
Phase: Phase 2
Start: Apr 30, 2007
Completion: Feb 28, 2009
NCT00607841
A Study of Ispinesib in Metastatic Breast Cancer
Start: Dec 31, 2007
Completion: Nov 30, 2009
NCT00682565
PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina
Start: Apr 30, 2008
Completion: Mar 31, 2009
NCT00748579
Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency
Start: Sep 30, 2008
Completion: Jul 31, 2009
NCT00941681
Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure
Start: Apr 30, 2009
Completion: Oct 31, 2009
NCT01089010
A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Start: Mar 31, 2010
Completion: Nov 30, 2010
NCT01131013
A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication
Start: May 31, 2010
Completion: Mar 31, 2011
NCT01077167
Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients
Start: Jul 31, 2010
Completion: May 31, 2011
NCT01268280
Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis
Start: Dec 31, 2010
Completion: Oct 31, 2012
NCT01300013
Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
Start: Apr 30, 2011
Completion: Sep 30, 2013
NCT01378676
A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Start: Jun 30, 2011
Completion: Mar 31, 2012
NCT01486849
Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Start: Nov 30, 2011
NCT01709149
Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)
Start: Oct 31, 2012
Completion: Mar 31, 2014
NCT01737866
Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency
Start: Nov 30, 2012
Completion: May 31, 2013
NCT01786512
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
Start: Feb 26, 2013
Completion: Aug 19, 2015
NCT02496767
Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year
Phase: Phase 3
Start: Sep 3, 2015
Completion: Sep 27, 2017
NCT02601001
Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults
Start: Nov 13, 2015
Completion: Jan 6, 2016
NCT02644668
A Study of CK-2127107 in Patients With Spinal Muscular Atrophy
Start: Jan 14, 2016
Completion: May 31, 2018
NCT02695420
Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction
Start: Apr 14, 2016
Completion: May 8, 2017
NCT02662582
A Study to Assess the Effect of CK-2127107 on Physical Function in Subjects With Chronic Obstructive Pulmonary Disease
Role: Collaborator
Start: Jun 30, 2016
Completion: Jun 8, 2018
NCT02936635
A Study for Patients Who Completed VITALITY-ALS (CY 4031)
Start: Oct 17, 2016
Completion: Oct 26, 2018
NCT02929329
Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
Start: Jan 6, 2017
Completion: Sep 14, 2020
NCT03065959
A Study to Assess the Anti-fatigability Effect of CK-2127107 in Elderly Male and Female Subjects With Limitations in Mobility
Start: Jun 28, 2017
Completion: Oct 10, 2018
NCT03160898
A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Start: Jul 24, 2017
Completion: Mar 7, 2019
NCT03767855
A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects
Start: Dec 4, 2018
Completion: Jan 3, 2020
NCT03840551
Definition of Biomechanical Indices Measurable During Sport Movements for the Prevention of Primary and Secondary ACL Injury
Phase: N/A
Start: Dec 15, 2018
Completion: Oct 1, 2020
NCT03759392
Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure
Start: Apr 9, 2019
Completion: Jan 6, 2022
NCT04175808
Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults
Start: Nov 14, 2019
Completion: Mar 4, 2020
NCT04219826
Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM
Start: Jan 10, 2020
Completion: Feb 28, 2023
NCT04464525
Omecamtiv Mecarbil Post-trial Access Study
Start: Dec 18, 2020
Completion: Nov 27, 2026
NCT04783766
Safety, Tolerability and Pharmacokinetics Study of CK-3773274
Start: Apr 10, 2021
Completion: Aug 5, 2021
NCT04848506
Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM
Phase: Phase 2/3
Start: May 6, 2021
Completion: Mar 31, 2028
NCT04944784
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)
Start: Aug 16, 2021
Completion: Jul 18, 2023
NCT05186818
Aficamten vs Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (SEQUOIA-HCM)
Start: Feb 1, 2022
Completion: Dec 18, 2023
NCT05442775
A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)
Start: Aug 4, 2022
Completion: Jun 7, 2023
NCT05662215
A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants
Start: Dec 6, 2022
Completion: Aug 8, 2023
NCT05877053
A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants
Start: May 9, 2023
Completion: Nov 20, 2024
NCT05924815
Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval
Start: May 15, 2023
Completion: Nov 14, 2023
NCT05767346
Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM
Start: Jun 20, 2023
Completion: Mar 28, 2025
NCT06081894
Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
Start: Aug 30, 2023
Completion: Sep 30, 2026
NCT06412666
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
Start: May 29, 2024
Completion: Jan 31, 2030
NCT06736574
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Start: Dec 19, 2024
Completion: Dec 31, 2027
NCT06793371
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Start: Feb 6, 2025
NCT07054073
HCMR Re-Imaging Study
Start: Jul 30, 2025
Completion: Jul 31, 2026
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