NCT00624442 - A Study of CK-1827452 Infusion in Stable Heart Failure | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

April 30, 2007

Primary Completion Date

February 28, 2009

Study Completion Date

February 28, 2009

Conditions

Heart Failure

Interventions

DRUG

CK-1827452

IV infusion for 1 hour at 0.125 mg/kg/h followed by 1 hour at 0.0625 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.25 mg/kg/h followed by 1 hour at 0.125 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.5 mg/kg/h followed by 1 hour at 0.25 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.75 mg/kg/h followed by 1 hour at 0.375 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 1.0 mg/kg/h followed by 1 hour at 0.5 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.25 mg/kg/h followed by 1 hour at 0.125 mg/kg/h followed by 22 hours at 0.025 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.5 mg/kg/h followed by 1 hour at 0.25 mg/kg/h followed by 22 hours at 0.05 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 1.0 mg/kg/h followed by 1 hour at 0.5 mg/kg/h followed by 22 hours at 0.1 mg/kg/h

DRUG

Placebo

IV infusion for 2 hours

DRUG

Placebo

IV infusion for 24 hours

DRUG

CK-1827452

IV infusion for 1 hour at 1.0 mg/kg/h followed 1 hour at 0.5 mg/kg/h followed by 70 hours at 0.1 mg/kg/h

DRUG

Placebo

IV infusion for 72 hours

DRUG

CK-1827452

IV infusion for 1 hour at 0.75 mg/kg/h followed 1 hour at 0.5 mg/kg/h followed by 70 hours at 0.1 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.25 mg/kg/h followed by 23 hours at 0.025 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 0.5 mg/kg/h followed by 23 hours at 0.05 mg/kg/h

DRUG

CK-1827452

IV infusion for 1 hour at 1.0 mg/kg/h followed by 23 hours at 0.1 mg/kg/h

Trial Locations (17)

19713

Christiana Care Health Services, Inc., Newark

92103

University of California, San Diego Medical Center, San Diego

121552

Russian Cardiological Research and Production Complex, Moscow

192242

Dzhanelidze Research Institute for Emergency Medical Care, Saint Petersburg

194156

Almazov Federal Heart, Blood and Endocrinology Center, Saint Petersburg

197089

St. Petersburg State Medical University, Saint Petersburg

Unknown

Diagnostic Services Clinic, Tbilisi

HU16 5JQ

Castle Hill Hospital, University of Hull, Hull

SE5 9RS

King's College Hospital, London

SW17 ORE

St. George's Hospital, London

W2 1LA

St. Mary's Hospital & Imperial College, London

M13 9WL

Manchester Heart Centre, Manchester Royal Infirmary, Manchester

M15 6SH

ICON Development Solutions, Manchester

M23 9LT

Wythenshawe Hospital, Manchester

HA1 3UJ

Northwick Park Hospital, Middlesex

DD1 9SY

Ninewells Hospital and Medical School, Dundee

G12 8TA

BHF Cardiovascular Centre, Glasgow