Aficamten vs Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (SEQUOIA-HCM)

PHASE3CompletedINTERVENTIONAL
Enrollment

282

Participants

Timeline

Start Date

February 1, 2022

Primary Completion Date

November 10, 2023

Study Completion Date

December 18, 2023

Conditions
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Interventions
DRUG

Aficamten (5 mg, 10 mg, 15 mg, and 20 mg)

Aficamten tablets were administered orally once daily.

DRUG

Placebo to match aficamten

Placebo tablets were administered orally once daily.

Trial Locations (114)

1105

Amsterdam UMC, location AMC, Amsterdam

2100

Hjertecentret (The Heart Center), Copenhagen

2400

Copenhagen University Hospital, Copenhagen

3015

Erasmus Medical Center, Rotterdam

8200

Department of Cardiology Aarhus University Hospital, Aarhus

9100

Aalborg University Hospital, Department of Cardiology, Aalborg

10016

NYU Langone Health, New York

10019

Peking University Third Hospital, Beijing

10029

Mount Sinai Hospital, New York

10032

Columbia University Medical Center/NY Presbyterian Hospital, New York

10595

Westchester Medical Center, Valhalla

Sanger Heart and Vascular Institute, Charlotte

12808

Interni klinika kardiologie a angiologie, Prague

13005

CHU de Marseille - Hopital de la Timone Service de cardiologie, Marseille

13100

Ziv Medical Center, Safed

13353

Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum (CVK) Medizinische Klinik mit Schwerpunkt Kardiologie, Berlin

15006

Complejo Hospitalario Universitario, A Coruña

15213

UPMC Presbyterian, Pittsburgh

19104

Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia

20010

MedStar Washington Hospital Center, Washington D.C.

21218

MedStar Medical Group Cardiology at Union Memorial, Baltimore

21237

Medstar Franklin Square Medical Center, Baltimore

22908

University of Virginia Health System University Hospital, Charlottesville

25123

UOC Cardiologica Azienda Ospedaliera Spedali Civili di Brescia, Brescia

27560

Duke Health Center Arringdon, Morrisville

28204

Sanger Heart and Vascular Institute - HCM Clinic, Charlotte

30214

Piedmont Fayette Hospital, Fayetteville

30322

Emory Clinic, Atlanta

31059

Hopital Universitaire de Rangueil (CHU de Toulouse) Service de Cardiologie, Toulouse

32224

Mayo Clinic Florida, Jacksonville

33308

Holy Cross Hospital / Cardiology Associates, Fort Lauderdale

33600

CHU de Bordeaux Hopital Cardiologique Haut-Leveque, Pessac

33604

CHU du Haut Lveque Cardiologie, Pessac

37007

Hospital Universitario de Salamanca, Salamanca

37075

Klinikumder Georg-August-Universitaet, Göttingen

Universitaetsmedizin Goettingen, Göttingen

37232

Vanderbilt University Medical Center, Nashville

38138

Stern Cardiovascular Foundation, Inc, Germantown

39120

Unniversitaetsklinikum Magdeburg Klinik fur Kardiologie und Anglologie, Magdeburg

41009

Hospital Universitario Virgen Macarena-merge, Seville

43210

The Ohio State University Wexner Medical Center, Columbus

44093

CHU de Nantes, Nantes

44195

Cleveland Clinic, Cleveland

45147

Universitaetsklinikum Essen Westdeutsches Herz-Gefaesszentrum, Essen

48109

Michigan Medicine, Ann Arbor

48202

Henry Ford Medical Center, Detroit

49525

Spectrum Health Medical Group Cardiovascular Medicine, Grand Rapids

50134

Azienda Ospedaliero Universitaria Careggi Dipartimento Cardiotoracovascolare - Cardiomiopatie Unit, Florence

52242

University of Iowa, Iowa City

53226

Froedtert Hospital, Milwaukee

55455

M Health Fairview University of Minnesota Medical Center - East Bank, Minneapolis

55905

Mayo Clinic, Rochester

56124

Fondazione toscana Gabriele Monesterio per la ricarca medica Dipartimento Cardiotoracico UOC Cardiologia e Medicina Cardiovasculare Ospedale San Cataldo, Pisa

60614

Northwestern University, Chicago

61231

Kerckhoff-Klinik GmbH Abteilung Administration Forschung und Lehre, Bad Nauheim

63110

Washington University School of Medicine, St Louis

64111

Saint Luke's Hospital of Kansas City, Kansas City

74104

Ascension St. John Clinical Research Institute, Tulsa

75010

Hopital Lariboisiere, Service de Cardiologie, Paris

75015

Hôpital Européen Georges Pompidou, Paris

75390

The University of Texas Southwestern Medical Center, Dallas

76100

Kaplan Medical Center, Rehovot

77030

Houston Methodist Hospital, Houston

78100

The Barzilai University Medical Center, Ashkelon

84132

University of Utah Hospital, Salt Lake City

90048

Cedars-Sinai Medical Center - Smidt Heart Institute Clinic, Los Angeles

92037

UC San Diego Health - Sulpizio Cardiovascular Center, La Jolla

94143

University of California San Francisco, San Francisco

94305

Stanford University Hospital, Stanford

97239

Oregon Health & Science University, Portland

98195

University of Washington Medical, Seattle

99508

Alaska Heart and Vascular Institute, Anchorage

100020

Beijing Chao-Yang Hospital, Capital Medical University, Beijing

100029

Beijing Anzhen Hospital, Beijing

130031

The First Hospital of Jinlin University, Changchun

410008

Xiangya Hospital of the Central South University, Changsha

430022

Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan

450018

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

516006

Nanfang Hospital Southern Medical University, Guanzhou

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

5265601

The Olga & Lev Leviev Heart Center The Chaim Sheba Medical Center, Ramat Gan

7830604

The Barzilai University Medical Center, Ashkelon

9112001

Hadassah Medical Center- Ein Kerem, Jerusalem

06511

Yale School of Medicine, New Haven

06519

Yale University School of Medicine, New Haven

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

01805

Lahey Hospital & Medical Center, Burlington

07960

Morristown Medical Center, Morristown

128 08

Charles University, Prague

Unknown

CHU Pitie-Salpetriere, Centre de reference maladies cardiaques hereditaires ou rares, Paris

Universitaetsklinikum Heidelberg, Heidelberg

Universitätsklinikum Würzburg, Würzburg

Semmelweis Egyetem Varosmajori Sziv es Ergyogyasazati Klinika, Budapest

Kardio Brynow S.C, Katowice

Krakowskie Centrum, Krakow

Hospital Universitario Puerta de Hierro, Madrid

Hospital Clinico Universitario Virgen de la Arrixaca, Murcia

07747

Universitaetsklinikum Jena Klinik fuer Innere Medizin 1, Jena

1035-39

Dipartimento di Medicina Clinica e Molecolare Universita Sapienza di Roma Unita di Terapia Intensiva Cardiologica Azienda Ospedaliero Universitaria Sant'Andrea, Roma

6229HX

University Hospital Maastricht, Maastricht

04-628

Narodowy Instytut Kardiologii Stefana Kardynała Wyszynskiego- Panstwowy Instytut Badawczy, Warsaw

3814-501

Centro Hospitalar Do Baixo Vouga, EPE AV ARTUR RAVARA, Aveiro

1500-650

Hospital da Luz, Lisbon

08036

Hospital Clinic de Barcelona, Barcelona

07198

Hospital Universitario Son Llatzer Secretaria de Cardiologia, Palma

B15 2GW

Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust, Edgbaston

G1 4TF

Queen Elizabeth University Hospital - HWS Greater Glasgow and Clyde, Glasgow

L14 3LB

Liverpool Heart and Chest Hospital - Liverpool Heart and Chest Hospital NHS Foundation Trust- HWS Greater Glasgow and Clyde, Liverpool

EC1A 7BE

Barts Health NS Trust, London

SW17 0QT

St George's University Hospitals NHS Foundation Trust, London

SW3 6NP

Royal Brompton Hospital, London

OX3 9DU

Oxford Centre for Clinical Magnetic Resonance Research, Oxford

Radcliffe Department of Medicine, Oxford

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Corxel Pharmaceuticals

INDUSTRY

lead

Cytokinetics

INDUSTRY