175
Participants
Start Date
June 20, 2023
Primary Completion Date
February 28, 2025
Study Completion Date
March 28, 2025
Aficamten (CK-3773274) (5 mg, 10 mg, 15 mg and 20 mg)
Aficamten (CK-3773274) tablets administered orally
Placebo to match aficamten
Placebo for aficamten (CK-3773274) administered orally
Metoprolol succinate (50 mg, 100 mg, 150 mg and 200 mg)
Metoprolol succinate tablets administered orally
Placebo to match metoprolol succinate
Placebo for metoprolol succinate administered orally
Columbia University Medical Center/New York Presbyterian Hospital, New York
Division of Heart Failure and Transplantation (Hospital of the University of Pennsylvania), Philadelphia
Inova Schar Heart and Vascular, Falls Church
Duke Health Center Arringdon, Morrisville
Sanger Heart & Vascular Institute - HCM Clinic, Charlotte
Medical University of South Carolina, Charleston
Piedmont Fayette Hospital, Fayetteville
Emory Clinic, Atlanta
AdventHealth, Orlando
Ascension Saint Thomas Heart West, Nashville
Vanderbilt University Medical Center, Nashville
Henry Ford Hospital, Detroit
Northwestern University, Evanston
Saint Luke's Hospital of Kansas City, Kansas City
CHI St. Luke's Health Baylor-St. Luke's Medical Center, Houston
Houston Methodist Hospital, Houston
Intermountain Medical Center, Murray
Mayo Clinic, Phoenix
Cedars-Sinai Medical Center (Smidt Heart Institute), Los Angeles
UC San Diego Health - Sulpizio Cardiovascular Center, La Jolla
Providence St. Vincent Medical Center, Portland
Oregon Health & Science University, Portland
Alaska Heart and Vascular Institute, Anchorage
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou
Yale New Haven Hospital, New Haven
Massachusetts General Hospital, Boston
Brigham and Women's Hospital, Boston
Lahey Hospital & Medical Center, Burlington
Morristown Medical Center, Morristown
Institutdo Danta Pazzanese, Ibirapuera
Instituto de Pesquisa Clinica de Campinas - IPECC, Campinas
lnstituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo
Institut universitaire de cardiologie et de pneumonlogie de Quebec - Universite Laval, Québec
Xiangya Second Hospital of Central South University, Changsha
Guangdong Provincial People's Hospital, Guangzhou
Zhongshan Hospital Fudan University, Shanghai
Renmin Hospital of Wuhan University, Wuhan
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Aarhus University Hospital, Aarhus
Copenhagen University Hospital, Copenhagen
CHU La Timone, Marseille
Hopital Europeen Georges Pompidou, Paris
Hopital Lariboisiere - APHP, Paris
Hopital Cardiologique Haut Leveque - CHU de Bordeaux, Pessac
CHU Pontchaillou, Rennes
Hopital Laennec - CHU de Nantes, Saint-Herblain
Charite-Universitatsmedizin Berlin - Campus Virchow Klinikum, Berlin
Universitaetsklinikum Essen, Essen
Universitaetsklinikum Jena, Jena
Semmelweis Egyetem, Városmajori Szív- és Érgyógyászati Klinika, Budapest
Barzilai Medical Center, Ashkelon
Hadassah Hebrew Medical Center- Ein Kerem, Jerusalem
The Chaim Sheba Medical Center, Ramat Gan
Kaplan Medical Center, Rehovot
Ziv Medical Center, Safed
AOU Careggi, Florence
Erasmus Medical Center, Rotterdam
Complejo Hospitalario Universitario A Coruna, A Coruña
Hospital Clinic de Barcelona, Barcelona
Hospital Clinico Universitario Virgen Arrixaca, El Palmar
Hospital Universitario Puerta de Hierro, Madrid
Hospital Universitario de Salamanca, Salamanca
Hospital Universitario Virgen del Rocio, Seville
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Son Llatzer, Son Ferriol
NHS Greater Glasgow and Clyde, Glasgow
Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool
Barts Health NHS Trust, London
Royal Brompton Hospital, London
St George's University Hospitals NHS Foundation Trust, London
Oxford University Hospital NHS Trust - John Radcliffe Hospital - OCMR, Oxford
Lead Sponsor
Collaborators (1)
Sanofi
INDUSTRY
Cytokinetics
INDUSTRY