Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM

PHASE2CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

January 10, 2020

Primary Completion Date

February 28, 2023

Study Completion Date

February 28, 2023

Conditions
Hypertrophic Cardiomyopathy (HCM)
Interventions
DRUG

CK-3773274 (5 - 15 mg)

CK-3773274 tablets administered orally

DRUG

CK-3773274 (10 - 30 mg)

CK-3773274 tablets administered orally

DRUG

Placebo for CK-3773274

Placebo administered orally

Trial Locations (22)

10016

New York University Langone Health Medical Center, New York

15003

Complejo Hospitalario Universitario A Coruña, A Coruña

15213

UMPC Heart and Vascular Institute, Pittsburgh

19104

Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia

22903

University of Virginia Health System, Charlottesville

27713

Duke Cardiology at Southpoint, Durham

28203

Carolinas Medical Center, Charlotte

48109

Michigan Medicine - University of Michigan, Ann Arbor

60208

Northwestern University, Evanston

63110

Washington University School of Medicine, St Louis

75390

UT Southwestern Medical Center, Dallas

77030

Houston Methodist Hospital, Houston

84107

Intermountain Medical Center, Murray

90048

Cedar-Sinai Medical Center, Los Angeles

94143

UCSF Medical Center, San Francisco

97239

Oregon Health and Science University, Portland

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

Unknown

Azienda Ospedaliero Universitaria Careggi, Florence

Erasmus University Medical Center (Erasmus MC), Rotterdam

Hospital Universitario Puerta de Hierro de Majadahonda, Madrid

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cytokinetics

INDUSTRY

NCT04219826 - Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM | Biotech Hunter | Biotech Hunter