Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)

PHASE2CompletedINTERVENTIONAL
Enrollment

711

Participants

Timeline

Start Date

October 31, 2012

Primary Completion Date

March 31, 2014

Study Completion Date

March 31, 2014

Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG

CK-2017357

CK-2017357 125 mg tablets twice daily

OTHER

Placebo tablets

Tablets

DRUG

Riluzole

Tablets

Trial Locations (75)

9

Trinity College, Beaumont Hospital, Dublin

10021

Hospital for Special Surgery, New York

13005

Hôpital La Timone Adulte, Marseille

13120

SUNY Upstate Medical University, Syracuse

13353

Charite Universitätsmedizin, Berlin

14642

University of Rochester, Rochester

15213

University of Pittsburgh, Pittsburgh

17033

Penn State Hershey Neuroscience Clinics, Hershey

19107

Drexel Neurology, Philadelphia

University of Pennsylvania, Philadelphia

20037

The George Washington University, Washington D.C.

21205

Johns Hopkins University, Baltimore

22908

University of Virginia, Charlottesville

26506

West Virginia University Department of Neurology, Morgantown

27157

Wake Forest University, School of Medicine, Winston-Salem

27406

Carolinas Medical Center Department of Neurology, Charlotte

27705

Duke University, Durham

28029

Hospital Carlos III, Madrid

30322

Emory University, School of Medicine, Atlanta

30625

Hannover Medical School, Hanover

30912

Georgia Health Sciences University, Augusta

32224

Mayo Clinic Florida Department of Neurology, Jacksonville

37000

Hôpital Bretonneau, Tours

37232

Vanderbilt University Medical Center, Nashville

43221

Ohio State University Department of Neurology, Columbus

46202

Indiana University Department of Neurology, Indianapolis

48109

University of Michigan, Ann Arbor

48202

Henry Ford Hospital, Detroit

49503

St Mary's Healthcare, Grand Rapids

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Medical College of Wisconsin, Milwaukee

55415

Hennepin County Medical Center - Berman Center for Research, Minneapolis

63104

Saint Louis University, St Louis

63110

Washington University, St Louis

66160

University of Kansas, Kansas City

68506

Neurology Associates, Lincoln

75214

Texas Neurology, Dallas

77030

Baylor College of Medicine, Houston

78229

UTHSCSA Department of Neurology, San Antonio

85013

Barrow Neurology, Phoenix

89081

University of Ulm, Ulm

92093

University of California, San Diego, La Jolla

92103

Coordinated Clinical Research, San Diego

92868

UC Irvine ALS & Neuromuscular Center, Orange

94115

California Pacific Medical Center Forbes Norris MDA/ALS Research Center, San Francisco

97213

Providence ALS Center, Portland

97239

Oregon Health & Science University, Portland

06053

Hospital for Special Care, New Britain

02114

Massachusetts General Hospital, Boston

01655

University of Massachusetts Medical School, Worcester

03756

Dartmouth Hitchcock Medical Center, Lebanon

T2N 4Z6

Heritage Medical Research, Calgary

B3H 3A7

University of Alberta Hospital, Edmonton

QE II Health Sciences Centre, Halifax

V5Z 2G9

University of British Columbia, Vancouver

E3B 0C7

Stan Cassidy Centre for Rehabilitation, Fredericton

L8S 4K1

McMaster University Medical Centre, Hamilton

K7L 2V7

Queen's University : Kingston General, Kingston

N6A 5A5

London Health Sciences, London

M4N 3M5

Univ. of Toronto - Sunnybrook Health Sciences Centre, Toronto

H2L4M1

Hôpital Notre Dame (CHUM) Centre Hospitalier de l'Universite de Montreal, Montreal

H3A 2B4

Montreal Neurological Institute, Montreal

G1J 1Z4

CHU de Quebec: Hopital l'Enfant-Jesus, Québec

F-59037 LILLE cedex

CHRU de Lille - Hôpital Roger Salengro, Lille

87042 LIMOGES CEDEX

CHU de Limoges - Hôpital Dupuytren, Limoges

34295 Montpellier Cedex 5

CHU Montepellier, Montpellier

06602

Hôpital Archet 1, Nice

Cedex 13

Hôpital de la Salpêtrière, Paris

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

Unknown

Barts and the London MND & the Centre Royal London Hospital, Whitechapel

L9 7LJ

Walton Centre for Neurology and Neurosurgery, Liverpool

SE5 8AF

Kings College Hospital NHS Foundation Trust, London

OX3 9DU

John Radcliffe Hospital, Oxford

PL6 8DH

Plymouth Hospitals NHS Trust, Plymouth

S10 2HQ

Sheffield Institute for Translational Neuroscience, Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cytokinetics

INDUSTRY

NCT01709149 - Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) | Biotech Hunter | Biotech Hunter