Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure

PHASE3CompletedINTERVENTIONAL
Enrollment

276

Participants

Timeline

Start Date

April 9, 2019

Primary Completion Date

November 8, 2021

Study Completion Date

January 6, 2022

Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
DRUG

Omecamtiv Mecarbil

Oral omecamtiv mecarbil twice daily for up to 20 weeks with dose level determined by periodic blood testing

DRUG

Placebo

Oral placebo twice daily for up to 20 weeks

Trial Locations (81)

1122

Semmelweis University Heart and Vascular Center, Budapest

7624

Pecsi Tudomanyegyetem (PTE) Altalanos Orvostudomanyi Kar (AOK) (University of Pecs Medical School), Pécs

8230

Balatonfuredi Allami Szivkorhaz, Balatonfüred

10016

NYU Langone Medical Center, New York

11422

Queens Heart Institute, Rosedale

17011

Capital Area Research, LLC, Camp Hill

17033

Penn State Hershey Children's Hospital, Hershey

17603

Lancaster Heart And Stroke Foundation, Lancaster

20138

Centro Cardiologico Monzino IRCCS, Milan

21201

University of Maryland, Baltimore

22042

Inova Heart and Vascular Institute, Falls Church

22242

Enhet Klinisk forskning, hjartmedicin, Skanes Universitet Sjukhus, Lund

25123

Azienda Ospedaliera Spedali Civili di Brescia-Universita degli Studi Di Brescia, Brescia

27101

Wake Forest University School of Medicine, Winston-Salem

27610

Wake Med Health and Hospital, Raleigh

27710

Duke University Medical Center, Durham

29605

Greenville Health System, Greenville

30322

Emory University, Atlanta

31059

Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil, Toulouse

33024

Broward Research Center - Pembroke Pines, Pembroke Pines

38028

Groupe Hospitalier Mutualiste de Grenoble, Grenoble

38700

Centre Hospitalier Universitaire de Grenoble-Hopital Albert Michallon, La Tronche

39120

Universitatsklinikum Magdeburg, Magdeburg

40138

Azienda Ospedaliera S.Orsola Malpighi, Bologna

43210

The Ohio State University, Columbus

44093

Universite De Nantes - L'Institut Du Thorax, Nantes

46227

Community Hospital South, Inc., Indianapolis

46260

Saint Vincent Medical Group Inc., Indianapolis

48109

University of Michigan, Ann Arbor

48197

Michigan Heart, Ypsilanti

48202

Henry Ford Heart & Vascular Institute, Detroit

49770

McLaren Health Care Corporation, Petoskey

50556

Centrum Chorob Serca, Uniwersytecki Szpital Kllniczny im. Jana Mikulicza Radeckiego we Wrociawiu, Wroclaw

59901

Glacier View Research Institute, Cardiology, Kalispell

61231

Kerckhoff-Klinik- Bad Nauheim, Bad Nauheim

64109

Centre Hospitalier De La Cote Basque, Bayonne

64111

Saint Luke's Health System, Kansas City

66421

Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes, Homburg

68198

University of Nebraska Medical Center, Omaha

69120

Universitaetsklinik Heidelberg, Heidelberg

71100

Ospedali Riuniti Foggia, Foggia

72205

Arkansas Cardiology Clinic, Little Rock

74104

St. John Clinical Research Institute, Tulsa

75010

Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Lariboisiere, Paris

75235

University of Texas - Southwestern Medical Center, Dallas

75246

Baylor Scott and White Heart and Vascular Hospital, Dallas

76031

Chu de Rouen Hopital Charles Nicolle, Rouen

80120

South Denver Cardiology Associates, PC, Littleton

80131

Divisione di Cardiologia con Utic ed Emodinamica, Napoli

Ospedale Monaldi, Napoli

90509

Harbor-UCLA Medical Center, Torrance

97239

Oregon Health, Portland

99508

Alaska Heart and Vascular Institute, Anchorage

06102

Hartford Hospital-University of Connecticut School of Medicine, Hartford

33308-4603

Holy Cross Hospital - Fort Lauderdale, Fort Lauderdale

02114-2621

Massachusetts General Hospital (MGH) - Cardiac Unit Associates, Boston

08318

Cardiovascular Associates Of The Delaware Valley (Cadv), P.A. - Elmer Physicians Care Center - Elmer, Elmer

07112

Newark Beth Israel Medical Center, Newark

T2N 4Z6

Foothills Medical Centre, Calgary

N6A 5A5

London Health Sciences Centre - University Hospital, London

G7H 7K9

Ecogene-21, Chicoutimi

H1Y 3N1

Universite de Montreal Institut de Cardiologie de Montreal ICM Montreal Heart Institute MHI, Montreal

H3P1E1

Mcgill University Health Centre (MUHC)-The Montreal General Hospital (MGH), Montreal

07747

Universitaetsklinikum Jena, Jena

01099

Praxisklinik Dresden, Dresden

00163

Insituto Di Ricovero E Cura A Carattere Scientifico San Raffaele Pisana, Roma

3000 CA

Erasmus MC - Universitair Medisch Centrum Rotterdam, Rotterdam

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1061 AE

Onze Lieve Vrouwe Gasthuis (OLVG) Locatie West, Amsterdam

9713 GZ

University Medical Center Groningen, Groningen

2300RC

Leids Universitair Medisch Centrum (LUMC), Leiden

6500 HB

Radboud Universiteit - Radboud Universitair Medisch Centrum (Radboudumc), Nijmegen

3584 CX

Universitair Medisch Centrum Utrecht - Wilhelmina Kinderziekenhuis, Utrecht

5504 DB

Maxima Medisch Centrum Veldhoven, Veldhoven

35-055

Centrum Medyczne Medyk Sp z o.o. Sp. k., Rzeszów

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

80-952

Uniwersyteckie Centrum Kliniczne Kliniczne Centrum Kardiologii, Gdansk

31- 202

Oddzial Kliniczny Choroby Wiencowej i Niewydolnosci Serca z Pododdzialem Intensywnego Nadzoru Kardiologicznego, Krakow

93-513

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika, Oddzial Kardiologiczny, Lodz

04-628

Instytut Kardiologii Heart Failure Clinic, Warsaw

413 45

Sahlgrenska Universitetssjukhuset, Gothenburg

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cytokinetics

INDUSTRY

NCT03759392 - Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure | Biotech Hunter | Biotech Hunter