NCT00682565 - PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

April 30, 2008

Primary Completion Date

November 30, 2008

Study Completion Date

March 31, 2009

Conditions

Heart FailureMyocardial IschemiaAngina Pectoris

Interventions

DRUG

CK-1827452 24mg and 6 mg iv infusion

I.V. infusion for 2 hours at 24mg/hr followed by 18 hours at 6mg/hr

DRUG

CK-1827452 12.5mg capsule

12.5mg oral immediate release capsule

DRUG

CK-1827452 48 mg and 11 mg iv infusion

I.V. infusion for 2 hours at 48mg/hr followed by 18 hours at 11mg/hr

DRUG

CK-1827452 25mg capsule

25mg oral immediate release capsule

DRUG

Placebo iv infusion

Matching placebo iv infusion

DRUG

Placebo capsule

Matching placebo oral immediate release capsule

Trial Locations (14)

0102

Tbilisi State Medical University Clinic #1, Tbilisi

0141

Cardio-Reanimation Centre, Tbilisi

0144

Cardiology Clinic, Tbilisi

0159

National Center of Therapy, Tbilisi

0164

Multiprofile Clinical Hospital of Tbilisi #2, Tbilisi

0179

Diagnostic Services Clinic, Tbilisi

Unknown

Altay Territory Cardiology Dispensary, Barnaul

City Hospital #1, Barnaul

City Clinical Hospital #59, Moscow

City Clinical Hospital #64, Moscow

Moscow Municipal Clinical Hospital #4, Moscow

Federal Center of Heart, Blood and Endocrinology n.a. Almazov, Saint Petersburg

Research Centre for Cardiology n.a. Almazov under Roszdrav, Saint Petersburg

Volgograd Regional Cardiology Center, Volgograd