COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

PHASE2CompletedINTERVENTIONAL
Enrollment

544

Participants

Timeline

Start Date

February 26, 2013

Primary Completion Date

July 22, 2015

Study Completion Date

August 19, 2015

Conditions
Modified Release Oral FormulationLeft Ventricular Systolic DysfunctionChronic Heart FailureHistory of Chronic Heart FailureLeft Ventricular Ejection FractionPharmacokineticsEchocardiogram
Interventions
DRUG

Omecamtiv Mecarbil Matrix F1 Formulation

Modified release tablets for oral administration

DRUG

Omecamtiv Mecarbil Matrix F2 Formulation

Modified release tablets for oral administration

DRUG

Placebo

Modified release tablets matching to omecamtiv mecarbil

DRUG

Omecamtiv Mecarbil Swellable Core Technology F2

Modified release tablets for oral administration

Trial Locations (101)

1027

Research Site, Budapest

1125

Research Site, Budapest

1135

Research Site, Budapest

1527

Research Site, Sofia

2010

Research Site, Darlinghurst

2020

Research Site, Antwerp

2800

Research Site, Sandanski

2820

Research Site, Bonheiden

4000

Research Site, Liège

4002

Research Site, Plovdiv

4400

Research Site, Smolyan

4700

Research Site, Pazardzhik

5100

Research Site, Jászberény

6009

Research Site, Nedlands

6100

Research Site, Kazanlak

8800

Research Site, Sliven

8900

Research Site, Ieper

Research Site, Zalaegerszeg

9000

Research Site, Ghent

10467

Research Site, The Bronx

10567

Research Site, Cortlandt Manor

13353

Research Site, Berlin

17475

Research Site, Greifswald

19718

Research Site, Newark

21201

Research Site, Baltimore

25125

Research Site, Brescia

27100

Research Site, Pavia

27599

Research Site, Chapel Hill

27705

Research Site, Durham

29605

Research Site, Greenville

30322

Research Site, Atlanta

31201

Research Site, Macon

33136

Research Site, Miami

33180

Research Site, Aventura

33462

Research Site, Atlantis

33606

Research Site, Tampa

33756

Research Site, Clearwater

36608

Research Site, Mobile

37134

Research Site, Verona

37388

Research Site, Tullahoma

44137

Research Site, Dortmund

48202

Research Site, Detroit

49770

Research Site, Petoskey

50009

Research Site, Kaunas

53792

Research Site, Madison

55415

Research Site, Minneapolis

55417

Research Site, Minneapolis

60612

Research Site, Chicago

61231

Research Site, Bad Nauheim

63110

Research Site, St Louis

73120

Research Site, Oklahoma City

77030

Research Site, Houston

79189

Research Site, Bad Krozingen

89128

Research Site, Las Vegas

90033

Research Site, Los Angeles

90301

Research Site, Inglewood

91360

Research Site, Thousand Oaks

92037

Research Site, La Jolla

92626

Research Site, Costa Mesa

92780

Research Site, Tustin

93721

Research Site, Fresno

97239

Research Site, Portland

98195

Research Site, Seattle

06810

Research Site, Danbury

04210

Research Site, Auburn

37232-8802

Research Site, Nashville

T6G 2B7

Research Site, Edmonton

R2H 2A6

Research Site, Winnipeg

A1B 3V6

Research Site, St. John's

B3H 3A7

Research Site, Halifax

K1Y 4W7

Research Site, Ottawa

H3G 1A4

Research Site, Montreal

G1V 4G5

Research Site, Québec

J1G 2E8

Research Site, Sherbrooke

G8T 7A1

Research Site, Trois-Rivières

625 00

Research Site, Brno

636 00

Research Site, Brno

771 11

Research Site, Olomouc

128 08

Research Site, Prague

140 21

Research Site, Prague

568 25

Research Site, Svitavy

415 29

Research Site, Teplice

08661

Research Site, Vilnius

3813 TZ

Research Site, Amersfoort

9713 GZ

Research Site, Groningen

3584 CX

Research Site, Utrecht

15-276

Research Site, Bialystok

31-202

Research Site, Krakow

31-501

Research Site, Krakow

57-300

Research Site, Kłodzko

20-954

Research Site, Lublin

41-703

Research Site, Ruda Śląska

04-256

Research Site, Warsaw

50-981

Research Site, Wroclaw

DY1 2HQ

Research Site, Dudley

DD1 9SY

Research Site, Dundee

G11 6NT

Research Site, Glasgow

HA1 3UJ

Research Site, Harrow

LE3 9QP

Research Site, Leicester

L14 3PE

Research Site, Liverpool

EC1M 6BQ

Research Site, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cytokinetics

INDUSTRY

NCT01786512 - COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure | Biotech Hunter | Biotech Hunter