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Clinical Trials for Arcus Biosciences
Explore 27 clinical trials worldwide
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Showing 1-27 of 27 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Arcus Biosciences
Clinical Trials (27)
NCT07011719
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
PHASE3
Recruiting
720 participants
Started: Sep 8, 2025 · Completed: Dec 31, 2030
2 conditions
1 sponsor
5 locations
NCT07000149
A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC
PHASE3
Recruiting
1,116 participants
Started: Jul 28, 2025 · Completed: Jul 29, 2032
1 condition
2 sponsors
33 locations
NCT06919991
Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)
PHASE1
Active, not recruiting
14 participants
Started: May 2, 2025 · Completed: Oct 31, 2025
1 condition
1 sponsor
1 location
NCT06727565
Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma.
PHASE2
Recruiting
100 participants
Started: Feb 18, 2025 · Completed: Aug 31, 2026
1 condition
2 sponsors
25 locations
NCT06608927
Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
PHASE3
Active, not recruiting
610 participants
Started: Dec 13, 2024 · Completed: Nov 30, 2030
1 condition
2 sponsors
125 locations
NCT06048484
Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma
PHASE2
Recruiting
60 participants
Started: May 10, 2024 · Completed: Apr 30, 2027
1 condition
2 sponsors
5 locations
NCT06048133
Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)
PHASE2
Recruiting
33 participants
Started: Mar 8, 2024 · Completed: Jul 31, 2027
3 conditions
4 sponsors
4 locations
NCT06120075
A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies
PHASE1
Recruiting
91 participants
Started: Jan 19, 2024 · Completed: Nov 30, 2026
1 condition
1 sponsor
10 locations
NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
PHASE1
Active, not recruiting
40 participants
Started: Oct 13, 2023 · Completed: Mar 31, 2026
12 conditions
1 sponsor
15 locations
NCT05915442
Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer
PHASE2
Recruiting
23 participants
Started: Jul 1, 2023 · Completed: Dec 31, 2028
1 condition
2 sponsors
1 location
NCT05724563
Domvanalimab and Zimberelimab in Advanced Liver Cancers
PHASE2
Active, not recruiting
58 participants
Started: Jun 1, 2023 · Completed: Jun 1, 2027
4 conditions
3 sponsors
1 location
NCT05633667
Study of Novel Treatment Combinations in Patients With Lung Cancer
PHASE2
Recruiting
593 participants
Started: Mar 16, 2023 · Completed: Sep 30, 2029
3 conditions
2 sponsors
95 locations
NCT05688215
Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma
PHASE1/PHASE2
Recruiting
56 participants
Started: Mar 7, 2023 · Completed: Mar 2, 2026
2 conditions
2 sponsors
1 location
NCT05676931
Study With Various Immunotherapy Treatments in Participants With Lung Cancer
PHASE2
Active, not recruiting
400 participants
Started: Feb 21, 2023 · Completed: Dec 31, 2027
1 condition
2 sponsors
51 locations
NCT05419479
Switch Maintenance in Pancreatic
PHASE1/PHASE2
Recruiting
46 participants
Started: Nov 30, 2022 · Completed: Sep 30, 2028
4 conditions
3 sponsors
1 location
NCT05568095
A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
PHASE3
Active, not recruiting
1,040 participants
Started: Nov 21, 2022 · Completed: Feb 28, 2027
1 condition
3 sponsors
210 locations
NCT05536141
A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors
PHASE1
Recruiting
302 participants
Started: Oct 26, 2022 · Completed: Jul 31, 2027
2 conditions
1 sponsor
28 locations
NCT05502237
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
PHASE3
Recruiting
1,069 participants
Started: Oct 12, 2022 · Completed: Jun 30, 2028
1 condition
2 sponsors
227 locations
NCT05329766
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
PHASE2
Active, not recruiting
332 participants
Started: Jun 10, 2022 · Completed: Jun 30, 2027
1 condition
2 sponsors
49 locations
NCT05024097
A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
PHASE2
Recruiting
43 participants
Started: Mar 31, 2022 · Completed: Dec 31, 2030
1 condition
2 sponsors
3 locations
NCT05130177
Zimberelimab (AB122) With TIGIT Inhibitor Domvanalimab (AB154) in PD-1 Relapsed/Refractory Melanoma
PHASE2
Recruiting
26 participants
Started: Mar 16, 2022 · Completed: Jan 31, 2031
1 condition
2 sponsors
1 location
NCT05211895
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
PHASE3
Recruiting
860 participants
Started: Feb 18, 2022 · Completed: Sep 12, 2030
1 condition
2 sponsors
260 locations
NCT04791839
Safety and Efficacy of Zimberelimab (AB122) in Combination With Domvanalimab (AB154) and Etrumadenant (AB928) in Patients With Previously Treated Non-Small Cell Lung Cancer
PHASE2
Active, not recruiting
30 participants
Started: Aug 4, 2021 · Completed: Dec 31, 2029
3 conditions
2 sponsors
1 location
NCT04656535
AB154 Combined With AB122 for Recurrent Glioblastoma
EARLY_PHASE1
Active, not recruiting
46 participants
Started: Apr 21, 2021 · Completed: Dec 31, 2025
1 condition
3 sponsors
3 locations
NCT04736173
Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
PHASE2
Active, not recruiting
169 participants
Started: Feb 8, 2021 · Completed: May 31, 2027
4 conditions
2 sponsors
92 locations
NCT04104672
A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies
PHASE1
Active, not recruiting
196 participants
Started: Nov 6, 2019 · Completed: May 31, 2027
1 condition
1 sponsor
16 locations
NCT03821246
Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy
PHASE2
Recruiting
68 participants
Started: Oct 30, 2019 · Completed: Apr 30, 2026
3 conditions
3 sponsors
2 locations