Study of Novel Treatment Combinations in Patients With Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

593

Participants

Timeline

Start Date

March 16, 2023

Primary Completion Date

September 30, 2029

Study Completion Date

September 30, 2029

Conditions
Lung CancerAdvanced or Metastatic Non-Small-Cell Lung CancerResectable Non-Small-Cell Lung Cancer
Interventions
DRUG

Zimberelimab (ZIM)

Administered intravenously

DRUG

Domvanalimab (DOM)

Administered intravenously

DRUG

Sacituzumab govitecan-hziy (SG)

Administered intravenously

DRUG

Etrumadenant (ETRUMA)

Administered orally

DRUG

Carboplatin

Administered intravenously

DRUG

Cisplatin

Administered intravenously

DRUG

Pemetrexed

Administered intravenously

DRUG

Paclitaxel

Administered intravenously

DRUG

Nab-paclitaxel

Administered intravenously

DRUG

Docetaxel

Administered intravenously

DRUG

Nivolumab

Administered intravenously

Trial Locations (95)

100

RECRUITING

National Taiwan University Hospital,Substudy-01, Taipei

ACTIVE_NOT_RECRUITING

National Taiwan University Hospital,Substudy-02, Taipei

1509

RECRUITING

BP-A Beneficencia Portuguesa De Sao Paulo,Substudy-01, São Paulo

RECRUITING

Fundação Antonio Prudente/A.C. Camargo Cancer Center,Substudy-03, São Paulo

RECRUITING

Real e Benemérita Associação Portuguesa de Beneficência/Hospital Beneficência Portuguesa de São Paulo (Hospital BP),Substudy-03, São Paulo

8308

RECRUITING

Korea University Guro Hospital,Substudy-01, Seoul

RECRUITING

Korea University Guro Hospital,Substudy-03, Seoul

21100

RECRUITING

Dicle University,Substudy-01, Diyarbakır

21280

RECRUITING

Dicle University Medical Faculty,Substudy-03, Diyarbakır

22031

WITHDRAWN

US Oncology Investigational Products Center (IPC),Substudy-01, Fairfax

WITHDRAWN

US Oncology Investigational Products Center (IPC),Substudy-02, Fairfax

28644

RECRUITING

Chungbuk National University Hospital,Substudy-01, Cheongju-si

ACTIVE_NOT_RECRUITING

Chungbuk National University Hospital,Substudy-02, Cheongju-si

40503

RECRUITING

Baptist Health Lexington,Substudy-03, Lexington

42080

RECRUITING

Necmettin Erbakan University Meram Faculty of Medicine,Substudy-01, Konya

RECRUITING

Necmettin Erbakan Universitesi,Substudy-03, Meram Konya

45242

ACTIVE_NOT_RECRUITING

Oncology Hematology Care Clinical Trials, LLC,Substudy-01, Cincinnati

ACTIVE_NOT_RECRUITING

Oncology Hematology Care Clinical Trials, LLC,Substudy-02, Cincinnati

46845

RECRUITING

Fort Wayne Medical Oncology and Hematology, Inc.,Substudy-03, Fort Wayne

49100

WITHDRAWN

Rabin Medical Center,Substudy-03, Petah Tikva

49267

RECRUITING

Kosin University Gospel Hospital,Substudy-01, Seogu

RECRUITING

Kosin University Gospel Hospital,Substudy-03, Seogu

61469

RECRUITING

Chonnam National University Hwasun Hospital,Substudy-01, Gwangju

RECRUITING

Chonnam National University Hwasun Hospital,Substudy-03, Gwangju

63110

RECRUITING

Washington University School of Medicine - Siteman Cancer Center,Substudy-01, St Louis

ACTIVE_NOT_RECRUITING

Washington University School of Medicine - Siteman Cancer Center,Substudy-02, St Louis

RECRUITING

Washington University School of Medicine - Siteman Cancer Center,Substudy-03, St Louis

RECRUITING

Washington University School of Medicine - Siteman Cancer Center, St Louis

64239

RECRUITING

Tel Aviv Sourasky Medical Center,Substudy-01, Tel Aviv

ACTIVE_NOT_RECRUITING

Tel Aviv Sourasky Medical Center,Substudy-02, Tel Aviv

RECRUITING

Tel-Aviv Sourasky Medical Center,Substudy-03, Tel Aviv

78745

WITHDRAWN

Texas Oncology - Central South,Substudy-01, Austin

WITHDRAWN

Texas Oncology - Central South,Substudy-02, Austin

80218

WITHDRAWN

Rocky Mountain Cancer Center,Substudy-01, Denver

WITHDRAWN

Rocky Mountain Cancer Center,Substudy-02, Denver

80756

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-01, Kaohsiung City

ACTIVE_NOT_RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-02, Kaohsiung City

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-03, Kaohsiung City

83301

RECRUITING

Kaohsiung Chang Gung Memorial Hospital,Substudy-01, Kaohsiung City

ACTIVE_NOT_RECRUITING

Kaohsiung Chang Gung Memorial Hospital,Substudy-02, Kaohsiung City

RECRUITING

Kaohsiung Chang Gung Memorial Hospital,Substudy-03, Kaohsiung City

85711

WITHDRAWN

Arizona Oncology Associates,Substudy-01, Tucson

COMPLETED

Arizona Oncology Associates,Substudy-02, Tucson

91120

RECRUITING

Hadassah Medical Center,Substudy-01, Jerusalem

RECRUITING

Hadassah University Medical Center,Substudy-03, Jerusalem

97401

ACTIVE_NOT_RECRUITING

Oncology Associates of Oregon, PC,Substudy-01, Eugene

ACTIVE_NOT_RECRUITING

Oncology Associates of Oregon, PC,Substudy-02, Eugene

98109

WITHDRAWN

Fred Hutchinson Cancer Center,Substudy-01, Seattle

WITHDRAWN

Fred Hutchinson Cancer Center,Substudy-02, Seattle

410769

RECRUITING

National Cancer Center,Substudy-01, Goyang

ACTIVE_NOT_RECRUITING

National Cancer Center,Substudy-02, Goyang

RECRUITING

National Cancer Center,Substudy-03, Goyang

999077

RECRUITING

Queen Mary Hospital,Substudy-01, Hong Kong

ACTIVE_NOT_RECRUITING

Queen Mary Hospital,Substudy-02, Hong Kong

3525408

RECRUITING

Rambam Health Care Campus,Substudy-01, Haifa

ACTIVE_NOT_RECRUITING

Rambam Health Care Campus,Substudy-02, Haifa

RECRUITING

Rambam Health Care Campus,Substudy-03, Haifa

9103102

RECRUITING

Shaare Zedek Medical Center,Substudy-01, Jerusalem

ACTIVE_NOT_RECRUITING

Shaare Zedek Medical Center,Substudy-02, Jerusalem

RECRUITING

Shaare Zedek Medical Center,Substudy-03, Jerusalem

90610001

RECRUITING

Hospital Sao Lucas da PUC Rio Grande do Sul,Substudy-03, Porto Alegre

14784-400

RECRUITING

Fundação Pio XII - Hospital de Amor,Substudy-01, Barretos

90110-270

RECRUITING

Centro Gaúcho Integrado de Oncologia Hematologia, Ensino e Pesquisa Ltda./Hospital Mãe de Deus,Substudy-03, Porto Alegre

RECRUITING

Hospital Mae de Deus,Substudy-01, Porto Alegre

RECRUITING

Hospital Mae de Deus, Porto Alegre

Unknown

RECRUITING

Queen Elizabeth Hospital,Substudy-01, Hong Kong

ACTIVE_NOT_RECRUITING

Queen Elizabeth Hospital,Substudy-02, Hong Kong

RECRUITING

Prince of Wales Hospital,Substudy-01, New Territories

ACTIVE_NOT_RECRUITING

Prince of Wales Hospital,Substudy-02, New Territories

RECRUITING

Gazi University Medical Faculty,Substudy-03, Yenimahalle

463-707

RECRUITING

Seoul National University Bundang Hospital,Substudy-01, Gyeonggi-do

RECRUITING

Seoul National University Bundang Hospital,Substudy-03, Gyeonggi-do

WITHDRAWN

Seoul National University,Substudy-01, Seoul

ACTIVE_NOT_RECRUITING

Seoul National University,Substudy-02, Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System,Substudy-03, Seoul

05505

ACTIVE_NOT_RECRUITING

Asan Medical Center,Substudy-02, Seoul

RECRUITING

Asan Medical Center,Substudy-03, Seoul

RECRUITING

Asan Medical Centre,Substudy-01, Seoul

06351

RECRUITING

Samsung Medical Center,Substudy-01, Seoul

ACTIVE_NOT_RECRUITING

Samsung Medical Center,Substudy-02, Seoul

RECRUITING

Samsung Medical Center,Substudy-03, Seoul

120-752

RECRUITING

Severance Hospital, Yonsei University Health System,Substudy-01, Seoul

ACTIVE_NOT_RECRUITING

Severance Hospital, Yonsei University Health System,Substudy-02, Seoul

500-06

RECRUITING

Changhua Christian Hospital,Substudy-01, Changhua

ACTIVE_NOT_RECRUITING

Changhua Christian Hospital,Substudy-02, Changhua

RECRUITING

Changhua Christian Hospital,Substudy-03, Changhua

06520

RECRUITING

Memorial Ankara Hastanesi,Substudy-01, Ankara

RECRUITING

Memorial Ankara Hospital,Substudy-03, Ankara

B9 5SS

RECRUITING

Birmingham Heartlands Hospital,Substudy-03, Birmingham

RECRUITING

University Hospitals Birmingham NHS Trust,Substudy-01, Birmingham

ACTIVE_NOT_RECRUITING

University Hospitals Birmingham NHS Trust,Substudy-02, Birmingham

LS9 7TF

RECRUITING

St James University Hospital,,Substudy-01, Leeds

E1 1BB

RECRUITING

St. Bartholomew's Hospital,Substudy-01, London

ACTIVE_NOT_RECRUITING

St. Bartholomew's Hospital,Substudy-02, London

RECRUITING

St. Bartholomew's Hospital,Substudy-03, London

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Arcus Biosciences, Inc.

INDUSTRY

lead

Gilead Sciences

INDUSTRY

NCT05633667 - Study of Novel Treatment Combinations in Patients With Lung Cancer | Biotech Hunter | Biotech Hunter