Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 10, 2024

Primary Completion Date

April 30, 2027

Study Completion Date

April 30, 2027

Conditions
Pancreatic Ductal Adenocarcinoma
Interventions
RADIATION

Stereotactic body radiotherapy (SBRT)

SBRT 40 gray (Gy) over 5 fractions

DRUG

Zimberelimab

240 mg intravenously (IV)

DRUG

Quemliclustat

100 mg IV

DRUG

Etrumadenant

150 mg orally

DRUG

Modified FOLFIRINOX

"* Oxaliplatin 85 mg per square meter IV~* Irinotecan 150 mg per square meter IV~* Leucovorin 400 mg per square meter IV~* Fluorouracil 2400 mg per square meter IV~* Pegfilgrastim injector kit (6mg subcutaneous)"

Trial Locations (5)

10032

RECRUITING

Columbia University Irving Medical Center, New York

11042

RECRUITING

Northwell Health R.J. Zuckerberg Cancer Center, Lake Success

19104

RECRUITING

University of Pennsylvania, Abramson Cancer Center, Philadelphia

27514

RECRUITING

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Arcus Biosciences, Inc.

INDUSTRY

lead

Gulam Manji

OTHER