A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

332

Participants

Timeline

Start Date

June 10, 2022

Primary Completion Date

January 31, 2027

Study Completion Date

June 30, 2027

Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG

Domvanalimab

Administered as specified in the treatment arm

DRUG

Quemliclustat

Administered as specified in the treatment arm

DRUG

Zimberelimab

Administered as specified in the treatment arm

DRUG

Fluorouracil

Administered as specified in the treatment arm

DRUG

Leucovorin

Administered as specified in the treatment arm

DRUG

Oxaliplatin

Administered as specified in the treatment arm

Trial Locations (49)

10032

Columbia University, New York

22031

Virginia Cancer Specialists, Fairfax

27710

Duke University, Durham

32224

Mayo Clinic - Jacksonville, Jacksonville

33705

Florida Cancer Specialist - North, St. Petersburg

33901

Florida Cancer Specialist - South, Fort Myers

37203

SCRI Tennessee Oncology - Nashville, Nashville

37232

Vanderbilt-Ingram Cancer Center, Nashville

43219

Zangmeister Cancer Center, Columbus

73104

OU - Stephenson Cancer Center, Oklahoma City

85054

Mayo Clinic - Arizona, Phoenix

90024

Ronald Reagan UCLA Medical Center, Santa Monica

90033

USC/Norris Comprehensive Cancer Center, Los Angeles

06418

Yale Cancer Center, Derby

02109

Massachusetts General Hospital, Boston

10021-0005

Memorial Sloan Kettering Cancer Center, New York

Unknown

UHN - Princess Margaret Cancer Centre, Toronto

Clínica San Carlos de Apoquindo, Las Condes

Bradford Hill Centro de Investigaciones Clinicas, Recoleta

Centro de Estudios Clínicos SAGA, Santiago

Clínica Universidad Católica del Maule, Talca

Institut Bergonié _ Bordeaux, Bordeaux

CHU de Brest_Brest, Brest

Centre Baclesse - CAEN, Caen

Centre Oscar Lambret _ LILLE, Lille

Centre Léon Bérard _ Lyon, Lyon

Hôpital Timone - Marseille, Marseille

Institut de Recherche en Cancerologie de Montpellier, Montpellier

Centre Armoricain de Radiothérapie, d'Imagerie Médicale et d'Oncologie, Plérin

Pôle Régional de Cancérologie - Service d'Oncologie Médicale - Poitiers, Poitiers

CHU de Toulouse_Oncopole, Toulouse

Gustave Roussy - Villejuif, Villejuif

MSB - Medicinski Sistem Beograd, Belgrade

University Clinical Center of Serbia, Belgrade

University Hospital Medical Center (KBC) Bezanijska Kosa, Belgrade

Institute of Oncology of Vojvodina, Kamenitz

Clinical Center Kragujevac, Kragujevac

Dong-A University Hospital, Busan

Kyungpook National University Chilgok Hospital, Daegu

Chonnam National University Hwasun Hospital, Hwasun

CHA Bundang Medical Center, Seongnam-si

Asan Medical Center Hospital, Seoul

Korea University Anam Hospital, Seoul

Korea University Guro Hospital, Seoul

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

Severance Hospital Cancer Center, Seoul

Ajou University Hospital, Suwon

St. Vincent's Hospital, The Catholic University of Korea, Suwon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Arcus Biosciences, Inc.

INDUSTRY