Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

610

Participants

Timeline

Start Date

December 13, 2024

Primary Completion Date

November 30, 2030

Study Completion Date

November 30, 2030

Conditions
Metastatic Pancreatic Ductal Adenocarcinoma
Interventions
DRUG

Quemliclustat

Administered as specified in the treatment arm

DRUG

Placebo

Administered as specified in the treatment arm

DRUG

Nab-paclitaxel

Administered as specified in the treatment arm

DRUG

Gemcitabine

Administered as specified in the treatment arm

Trial Locations (125)

10016

New York University Medical Oncology Associates, New York

10032

Columbia University Irving Medical Center - Herbert Irving Pavilion, New York

10065

Memorial Sloan-Kettering Cancer Center - New York - Rockefeller Outpatient Pavilion, New York

10128

Mount Sinai Medical Center Comprehensive Cancer Center, New York

14263

Roswell Park Comprehensive Cancer Center, Buffalo

14642

James P. Wilmot Cancer Center, Rochester

15232

University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh

22031

Inova Medical Group - Hematology Oncology - Arlington, Fairfax

30318

Piedmont Cancer Institute, Atlanta

30322

Emory University Hospital, Atlanta

33176

Miami Cancer Institute, Miami

37232

Vanderbilt University Medical Center, Nashville

39401

MediSync Clinical Research - Hattiesburg Clinic, Hattiesburg

44106

University Hospitals Cleveland Medical Center, Cleveland

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

48109

University of Michigan Rogel Cancer Center, Ann Arbor

49503

Cancer & Hematology Centers of Western Michigan - Lemmen-Holton Cancer Pavilion, Grand Rapids

53792

University of Wisconsin - Madison, Madison

55404

HealthPartners Cancer Research Center - Cancer Center at Regions Hospital, Minneapolis

55905

Mayo Clinic - Rochester, Rochester

60005

USOR - Illinois Cancer Specialists - Arlington Heights, Arlington Heights

60611

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

64111

Saint Luke's Hospital of Kansas City, Kansas City

67208

Cancer Center of Kansas - Medical Arts Tower, Wichita

68105

University of Nebraska Medical Center, Omaha

70809

Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge

73104

Stephenson Cancer Center, Oklahoma City

75246

USOR - Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

77030

University of Texas MD Anderson Cancer Center, Houston

77598

USOR - Texas Oncology - Deke Slayton Cancer Center, Webster

78240

USOR - Texas Oncology - San Antonio Medical Center, San Antonio

78705

USOR - Texas Oncology - Austin Midtown, Austin

80218

USOR - Rocky Mountain Cancer Centers - Denver - Midtown, Denver

85054

Mayo Clinic Arizona - Phoenix Campus, Phoenix

85724

University of Arizona Cancer Center, Tucson

90404

UCLA Health - Santa Monica Cancer Care, Santa Monica

90720

Cancer & Blood Specialty Clinic - Los Alamitos, Los Alamitos

92093

University of California San Diego Health, La Jolla

94158

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

95661

Sutter Medical Center, Roseville

98101

Virginia Mason Medical Center, Seattle

98684

USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center, Vancouver

99208

Summit Cancer Centers - Spokane Valley, Spokane

90033-5315

Keck Medicine of USC - Keck Hospital of USC, Los Angeles

06520

Yale Cancer Center, New Haven

32224-1865

Mayo Clinic - Jacksonville, Jacksonville

08903-2681

Rutgers Cancer Institute of New Jersey, New Brunswick

19111-2497

Fox Chase Cancer Center, Philadelphia

Unknown

Chris O'Brien Lifehouse, Camperdown

Monash Health, Clayton

Oncology West - Murdoch, Murdoch

Wollongong Hospital, Wollongong

Salzburg Cancer Research Institute, Salzburg

Universitätsklinikum Sankt Pölten, Sankt Pölten

Krankenhaus Der Barmherzigen Brüder Wien, Vienna

Medizinische Universität Wien, Vienna

Institut Jules Bordet, Anderlecht

Imeldaziekenhuis, Bonheiden

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk

Ottawa Hospital - General Campus, Ottawa

Hôtel-Dieu de Sherbrooke, Sherbrooke

Princess Margaret Cancer Centre, Toronto

Sunnybrook Health Sciences Centre - Bayview Campus, Toronto

Fakultni Nemocnice Brno, Brno

Nemocnice AGEL Nový Jičín a.s., Nový Jičín

Fakultni nemocnice v Motole, Prague

Centre Georges François Leclerc, Dijon

Hôpital Huriez, Lille

Centre Léon Bérard, Lyon

Centre Hospitalier Universitaire de Poitiers, Poitiers

Gustave Roussy, Villejuif

Katholisches Klinikum Bochum - St. Josef-Hospital, Bochum

Krankenhaus Nordwest, Frankfurt am Main

Facharztzentrum Eppendorf, Hamburg

Katholisches Marienkrankenhaus, Hamburg

Medizinische Hochschule Hannover, Hanover

SLK-Kliniken Heilbronn - Klinikum am Gesundbrunnen, Heilbronn

Otto-von-Guericke Universität, Magdeburg

Elblandklinikum Riesa, Riesa

Universitätsklinikum Ulm, Ulm

Universitätsklinikum Würzburg, Würzburg

Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi, Bologna

Ospedale di Cremona, Cremona

Azienda Ospedaliero - Universitaria Careggi, Florence

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan

Istituto Europeo di Oncologia, Milan

Azienda Ospedaliero - Universitaria di Modena, Modena

Istituto Oncologico Veneto - IRCCS, Padua

Ospedale Guglielmo da Saliceto, Piacenza

IRCCS Istituto Nazionale Tumori Regina Elena, Roma

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas, Rozzano

Azienda Ospedaliero Universitaria Delle Marche, Torrette

Azienda Ospedaliera Universitaria Integrata Verona, Verona

National Cancer Center Hospital East, Kashiwa-shi

Cancer Institute Hospital of JFCR, Kōtō City

Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka

National Cancer Center Hospital, Tokyo

Toyama University Hospital, Toyama

Yamaguchi University Hospital, Ube

Kanagawa Cancer Center, Yokohama

Chonnam National University Hwasun Hospital, Hwasun

Cha Bundang Medical Center, Seongnam

Asan Medical Center, Seoul

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

Severance Hospital, Seoul

Hospital Clinic de Barcelona, Barcelona

Hospital Universitari Vall d'Hebrón, Barcelona

Hospital General Universitario de Elche, Elche

Institut Català d'Oncologia Girona (ICO Girona), Girona

Clínica Universidad de Navarra - Madrid, Madrid

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario HM Sanchinarro, Madrid

Hospital Universitario La Paz, Madrid

Clinica Universidad de Navarra - Pamplona, Pamplona

Hospital Universitario de Navarra, Pamplona

Hospital Alvaro Cunqueiro - Clinico Universitario Vigo, Vigo

Hospital Universitario Miguel Servet, Zaragoza

University Hospitals Birmingham NHS Foundation Trust, Birmingham

Hull University Teaching Hospitals NHS Trust, Cottingham

Royal Free London NHS Foundation Trust, London

Sarah Cannon Research Institute London, London

University College London Hospitals NHS Foundation Trust, London

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
collaborator

Taiho Pharmaceutical Co., Ltd.

INDUSTRY

lead

Arcus Biosciences, Inc.

INDUSTRY