AB154 Combined With AB122 for Recurrent Glioblastoma

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

April 21, 2021

Primary Completion Date

November 30, 2025

Study Completion Date

December 31, 2025

Conditions
Glioblastoma
Interventions
DRUG

Zimberelimab

Zimberelimab (AB122) is a fully human immunoglobulin G4 (hIgG4) monoclonal antibody (mAb) that targets PD-1.

DRUG

Domvanalimab

Domvanalimab (AB 154) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets TIGIT.

DRUG

Placebo

Saline placebo comparator for pre-surgery treatment in cohort B4

Trial Locations (3)

94143

University of California San Francisco, San Francisco

06519

Yale University, New Haven

02215

Dana Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Arcus Biosciences, Inc.

INDUSTRY

lead

Yale University

OTHER