Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,069

Participants

Timeline

Start Date

October 12, 2022

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Zimberelimab

Administered intravenously

DRUG

Domvanalimab

Administered intravenously

DRUG

Pembrolizumab

Administered intravenously

DRUG

Carboplatin

Administered intravenously

DRUG

Cisplatin

Administered intravenously

DRUG

Paclitaxel

Administered intravenously

DRUG

Nab-paclitaxel

Administered intravenously

DRUG

Pemetrexed

Administered intravenously

Trial Locations (227)

100

RECRUITING

National Taiwan University Hospital, Taipei

736

RECRUITING

Chi Mei Hospital, Liouying, Tainan City

807

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

824

ACTIVE_NOT_RECRUITING

E-DA Hospital, Kaohsiung City

1089

ACTIVE_NOT_RECRUITING

Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon

1426

WITHDRAWN

Centro Medico Barrio Parque, Ciudad Autanoma Buenos Aires

2000

RECRUITING

Sanatorio Britanico de Rosario, Rosario

2100

ACTIVE_NOT_RECRUITING

Centre Hospitalier de Saint-Quentin, Saint-Quentin

2800

ACTIVE_NOT_RECRUITING

AZ Sint-Maarten, Mechelen

3100

RECRUITING

Health Pharma Professional Research S.A. de C.V., México

4000

WITHDRAWN

CAIPO - Centro para la Atención Integral del Paciente Oncológico, San Miguel de Tucumán

4020

ACTIVE_NOT_RECRUITING

Ordensklinikum Linz GmbH, Elisabethinen, Linz

4600

ACTIVE_NOT_RECRUITING

Klinikum Wels-Grieskirchen, Wels

5000

RECRUITING

Sanatorio Allende, Córdoba

ACTIVE_NOT_RECRUITING

CHU UCL Namur / Site Sainte Elisabeth, Namur

6000

ACTIVE_NOT_RECRUITING

Grand Hopital de Charleroi asbl (GHdC), Charleroi

6189

WITHDRAWN

Centre Antoine Lacassagne, Nice

6200

ACTIVE_NOT_RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara

6351

RECRUITING

Samsung Medical Center, Gangnam-Gu

8028

ACTIVE_NOT_RECRUITING

Hospital Universitari Dexeus (USP Institut Universitari Dexeus/Hospital Universitari Quiron Dexeus), Barcelona

8035

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall D'Hebron, Barcelona

8208

ACTIVE_NOT_RECRUITING

Hospital Parc Tauli, Barcelona

8500

RECRUITING

Clínica Viedma, Viedma

9116

WITHDRAWN

Klinikum Chemnitz gGmbH, Chemnitz

9300

ACTIVE_NOT_RECRUITING

Algemeen Ziekenhuis Sint-Lucas, Aalst

10002

RECRUITING

Taipei Veterans General Hospital, Taipei

10060

WITHDRAWN

IRCCS Fondazoine del Piemonte per l'Oncologia, Candiolo

13005

ACTIVE_NOT_RECRUITING

Hopital Nord, Marseille

14000

WITHDRAWN

CHU de Caen, Caen

14004

ACTIVE_NOT_RECRUITING

Hospital Universitario Reina Sofia, Córdoba

15212

RECRUITING

AHN Allegheny General Hospital, Pittsburgh

16132

ACTIVE_NOT_RECRUITING

Ospedale Policlinico San Martino, Genova

16247

RECRUITING

The Catholic University of Korea, Saint Vincent's Hospital, Suwon

16499

WITHDRAWN

Ajou University Hospital, Suwon

17007

ACTIVE_NOT_RECRUITING

Hospital Doctor Josep Trueta, Girona

20052

RECRUITING

George Washington Medical Faculty Associates, Washington D.C.

20132

ACTIVE_NOT_RECRUITING

Ospedale San Raffaele, Milan

21075

ACTIVE_NOT_RECRUITING

Asklepios Kliniken Hamburg, Hamburg

21565

RECRUITING

Gachon University Gil Medical Center, Inchon

22030

ACTIVE_NOT_RECRUITING

Trakya University Faculty of Medicine, Edirne

22087

ACTIVE_NOT_RECRUITING

Katholisches Marienkrankenhaus gGmbH, Hamburg

22205

WITHDRAWN

US Oncology Investigational Products Center (IPC), Arlington

22332

WITHDRAWN

Inha University Hospital, Incheon

22927

ACTIVE_NOT_RECRUITING

LungenClinic Grosshansdorf, Großhansdorf

23007

ACTIVE_NOT_RECRUITING

Hospital Universitario de Jaen, Jaén

23538

ACTIVE_NOT_RECRUITING

Universitatsklinikum Schleswig-Holstein, Lübeck

24047

WITHDRAWN

ASST Bergamo Ovest- ospedale di Treviglio, Treviglio

24060

ACTIVE_NOT_RECRUITING

Oncology and Hematology Associates of Southwest Virginia, Inc, Blacksburg

26100

ACTIVE_NOT_RECRUITING

Azienda Socio Sanitaria Territoriale di Cremona, Cremona

27100

ACTIVE_NOT_RECRUITING

IRCCS Policlinico S. Matteo, Dipartimento Oncologia Ematologia-Oncologia Medica, Pavia

28020

ACTIVE_NOT_RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28027

ACTIVE_NOT_RECRUITING

Clinica Universidad de Navarra, Madrid

28046

ACTIVE_NOT_RECRUITING

Hospital Universitario La Paz, Madrid

28222

ACTIVE_NOT_RECRUITING

Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda

28806

ACTIVE_NOT_RECRUITING

Messino Cancer Centers, Asheville

29011

ACTIVE_NOT_RECRUITING

Hospital Regional Universitario de Malaga, Rincón de la Victoria

29100

ACTIVE_NOT_RECRUITING

Ospedale Guglielmo da Saliceto AUSL di Piacenza, Piacenza

30318

WITHDRAWN

Peachtree Hematology Oncology Consultants, Atlanta

32024

WITHDRAWN

Lake City Cancer Care, Lake City

32429

ACTIVE_NOT_RECRUITING

Johannes Wesling Klinikum Minden, Minden

33081

ACTIVE_NOT_RECRUITING

Centro di Riferimento Oncologico, Pordenone

33305

RECRUITING

Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan

33612

RECRUITING

Moffitt Cancer Center, Tampa

34093

ACTIVE_NOT_RECRUITING

Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi, Istanbul

34098

ACTIVE_NOT_RECRUITING

Istanbul University Cerrahpasa Medical Faculty Hospital, Fatih

34125

WITHDRAWN

Klinikum Kassel, Kassel

34232

WITHDRAWN

Florida Cancer Specialists, Sarasota

34303

ACTIVE_NOT_RECRUITING

Acibadem Mehmet Ali Aydinlar Universitesi Atakent Hastanesi, Kaakaekmece

34928

ACTIVE_NOT_RECRUITING

Institut de Cancer de Montpellier (ICM) - Val d'Aurelle, Montpellier

35016

ACTIVE_NOT_RECRUITING

Hospital Universitario de Canarias, Las Palmas de Gran Canaria

41009

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen Macarena, Seville

41014

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen del Rocio, Seville

41124

WITHDRAWN

Azienda Ospedaliero Universitaria di Modena, Modena

43204

ACTIVE_NOT_RECRUITING

Hospital Sant Joan de Reus, Reus

44300

ACTIVE_NOT_RECRUITING

Turgut Ozal Medical Faculty, Malatya

44791

WITHDRAWN

Augusta-Kranken-Anstalt gGmbh Klinik für Hämatologie Onkologie und Palliativmedizin, Bochum

44805

ACTIVE_NOT_RECRUITING

Institut de cancerologie de l'ouest (ICO), Saint-Herblain

45122

ACTIVE_NOT_RECRUITING

Universitatsklinikum Essen / Westdeutsches Tumorzentrum, Innere Klinik (Tumorforschung), Essen

45242

ACTIVE_NOT_RECRUITING

Oncology Hematology Care, Inc., Cincinnati

46009

ACTIVE_NOT_RECRUITING

Instituto Valenciano De Oncologia (IVO), Valencia

46015

ACTIVE_NOT_RECRUITING

Hospital Universitari i Politecnic La Fe, Valencia

ACTIVE_NOT_RECRUITING

Hospital Vithas Valencia 9 de Octubre, Valencia

49100

ACTIVE_NOT_RECRUITING

Rabin Medical Center, Petah Tikva

49267

WITHDRAWN

Kosin University Gospel Hospital, Seogu

51109

ACTIVE_NOT_RECRUITING

Kliniken der Stadt Köln ggmbh, Krankenhaus Koln-Merheim/Lungenklinik, Cologne

58675

ACTIVE_NOT_RECRUITING

Lungenklinik Hemer, Zentrum fur Pneumologie and Thoraxchirurgie, Hemer

61122

ACTIVE_NOT_RECRUITING

Azienda Sanitaria Territoriale Pesaro e Urbino (AST), Pesaro

61615

ACTIVE_NOT_RECRUITING

Illinois Cancer Care, Peoria

63069

ACTIVE_NOT_RECRUITING

Sana Klinikum Offenbach GmbH, Medizinische Klinik IV, Hämatologie und Internistische Onkologie, Offenbach

64239

ACTIVE_NOT_RECRUITING

Tel-Aviv Sourasky Medical Center, Tel Aviv

64460

ACTIVE_NOT_RECRUITING

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Mitras Centro

67033

WITHDRAWN

Institut de Cancerologie Strasbourg Europe (ICANS), Strasbourg

68000

ACTIVE_NOT_RECRUITING

Oaxaca Site Management Organization, Oaxaca City

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca, Oaxaca City

70403

WITHDRAWN

National Cheng Kung University Hospital, Tainan City

72000

ACTIVE_NOT_RECRUITING

Clinique Victor Hugo, Centre de Cancerologie de la Sarthe, Le Mans

72530

RECRUITING

Clinica Integral Internacional de Oncologia S de RL de CV, Puebla City

75090

WITHDRAWN

Texas Oncology- Denison, Sherman

75246

WITHDRAWN

Texas Oncology, Dallas

76012

WITHDRAWN

Arlington Cancer Center, Arlington

76100

WITHDRAWN

Kaplan Medical Center, Rehovot

76137

ACTIVE_NOT_RECRUITING

Vincentius-Diakonissen-Kliniken gAG, St. Vincentius-Kliniken, Medizinische Klinik 2, Karlsruhe

78745

RECRUITING

Texas Oncology - Austin, Austin

79106

WITHDRAWN

Universitätsklinikum Freiburg, Klinik für Innere Medizin I Hämatologie, Onkologie und Stammzelltransplantation, Freiburg im Breisgau

80131

ACTIVE_NOT_RECRUITING

AORN Cardarelli, Naples

WITHDRAWN

Azienda Ospedaliera dei Colli, Napoli

81925

WITHDRAWN

Munchen Klinik Bogenhausen, Klinik fur Pneumologie und Pneumologische Onkologie, München

83056

ACTIVE_NOT_RECRUITING

CHI de Toulon la Seyne-sur-Mer Hopital Sainte Musse, Toulon

83301

RECRUITING

Chang Gung Memorial Hospital Kaohsiung, Kaohsiung City

84101

WITHDRAWN

Soroka University Medical Center, Itzchak Rager Blvd., Beersheba

85304

WITHDRAWN

Palo Verde Hematology Oncology Ltd, Glendale

90606

RECRUITING

Innovative Clinical Research Institute, Whittier

91900

RECRUITING

FAICIC Clínical Research, Veracruz

92069

WITHDRAWN

California Cancer Associates for Research and Excellence, San Marcos

92100

ACTIVE_NOT_RECRUITING

Ambroise-Pare Hospital, Assistance Publique - Hopitaux de Paris, Boulogne-Billancourt

92150

ACTIVE_NOT_RECRUITING

Hôpital Foch, Suresnes

93105

WITHDRAWN

Texas Oncology, Santa Barbara

94160

ACTIVE_NOT_RECRUITING

Hopital d'Instruction des Armees (HIA) Begin, Saint-Mandé

94300

RECRUITING

Clinical Medical Research SC., Orizaba Centro

97401

RECRUITING

Hematology & Oncology Associates, Eugene

98684

RECRUITING

Northwest Cancer Specialists, PC, Vancouver

188770

WITHDRAWN

Raffles Hospital, Singapore

200030

RECRUITING

Shanghai Chest Hospital, Shanghai

200120

RECRUITING

Shanghai East Hospital, Shanghai

200433

ACTIVE_NOT_RECRUITING

Shanghai Pulmonary Hospital, Shanghai

210008

RECRUITING

Nanjing Drum Tower Hospital, Nanjing

230022

WITHDRAWN

Anhui Chest Hospital, Hefei

250021

ACTIVE_NOT_RECRUITING

Shandong Cancer Hospital, Jinan

300181

RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

308433

RECRUITING

Tang Tock Seng Hospital, Singapore

310005

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

330006

RECRUITING

The Second Affiliated Hospital of Nanchang University, Jiangxi

RECRUITING

Jiangxi Chest Hospital, Nanchang

350014

ACTIVE_NOT_RECRUITING

Fujian Cancer Hospital, Fuzhou

400030

RECRUITING

Chongqing University Cancer Hospital, Chongqing

410769

RECRUITING

National Cancer Center, Goyang

430022

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

430030

RECRUITING

Tongji Hospital Tongji Medical College of Hust, Wuhan

450008

RECRUITING

Henan Cancer Hospital, Zhengzhou

453100

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of Xinxiang Medical College, Xinxiang

510120

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

510180

RECRUITING

Guangzhou First People's Hospital, Guangzhou

510515

WITHDRAWN

Nanfang Hospital, Southern Medical University, Guangzhou

530021

RECRUITING

Guangxi Medical University Cancer Hospital, Nanning

610041

RECRUITING

West China Hospital Sichuan University, Chengdu

618000

RECRUITING

Deyang People's Hospital, Deyang

710049

RECRUITING

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

999077

RECRUITING

Queen Elizabeth Hospital, Hong Kong

RECRUITING

Queen Mary Hospital, Hong Kong

2520612

RECRUITING

Oncocentro APYS, Viña del Mar

2720276

ACTIVE_NOT_RECRUITING

Hospital Prof. Doutor Fernando Fonseca, Amadora

4800827

RECRUITING

James Lind Centro de Investigacion del Cancer, Temuco

5500243

RECRUITING

Clinica Puerto Montt, Port Montt

7500006

RECRUITING

Orlandioncologia, Providencia

7510035

RECRUITING

Oncovida- Santiago, Providencia

7550000

RECRUITING

Clinica Alemana de Santiago, Las Condes

8331143

RECRUITING

Biocinetic, Santiago

9103102

ACTIVE_NOT_RECRUITING

Shaare Zedek Medical Center, Jerusalem

17210080

RECRUITING

Centro Des Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho, São Paulo

06360

WITHDRAWN

Eastern CT Hematology and Oncology Associates, Norwich

F5300COE

RECRUITING

Investigaciones CORI S.R.L., Capital

X5008HHW

RECRUITING

Centro Médico Privado Centro de Especialidades Médicas Ambulatorias e Investigación Clínica, Cardoba

S2000DSV

RECRUITING

Sanatorio Parque de Rosario, Rosario

S2002KDS

RECRUITING

Hospital Provincial del Centenario, Rosario

S2013DTC

RECRUITING

Instituto Medico de la Fundacion Estudios Clinicos, Rosario

Unknown

WITHDRAWN

Klinikum Klagenfurt am Woerthersee, Klagenfurt

RECRUITING

Prince of Wales Hospital, New Territories

ACTIVE_NOT_RECRUITING

Oncology Institute, Galilee Medical Center, Route 89 Nahariya-Cabri, Nahariya

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera San Giuseppe Moscati, Avellino

ACTIVE_NOT_RECRUITING

TweeSteden Ziekenhuis, Tilburg

RECRUITING

Centro Hospitalar Universitário Lisboa Norte - Hospital Pulido Valente, Lisbon

ACTIVE_NOT_RECRUITING

Medipol Mega University Hospital, Istanbul

A-1140

ACTIVE_NOT_RECRUITING

Krankenhaus Nord - Klinik Floridsdorf, Vienna

30130-090

RECRUITING

Cenantron Centro Avançado de Tratamento Oncologico Ltda, Belo Horizonte

29308-014

RECRUITING

Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim

95070-560

RECRUITING

Fundacao Universidade De Caxias Do Sul - FUCS/RS, Caxias do Sul

60430-230

ACTIVE_NOT_RECRUITING

Instituto do Câncer do Ceará - ICC, Fortaleza

98700-000

RECRUITING

Oncosite - Centro de Pesquisa Clinica em Oncologia LTDA, Ijuí

90020-090

RECRUITING

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90035-903

RECRUITING

Hospital de Clínicas de Porto Alegre, Porto Alegre

90610-000

RECRUITING

Hospital São Lucas da PUCRS, Porto Alegre

96810-110

RECRUITING

Hospital Ana Nery Santa Cruz do Sul, Santa Cruz do Sul

03102002

RECRUITING

Instituto Brasiliero de Controle do Cancer IBCC, São Paulo

J4V 2H1

RECRUITING

Centre Integre de sante et de services sociaux de la Monteregie Centre, Greenfield Park

E1C 6Z8

RECRUITING

Moncton Hospital, Moncton

J7Z 2V4

ACTIVE_NOT_RECRUITING

CISSS des Laurentides, Québec

G5L5T1

RECRUITING

Centre de santé et services sociaux de Rimouski-Neigette, Rimouski

V8R 6V5

WITHDRAWN

BC Cancer - Victoria, Victoria

0754-88555844

RECRUITING

Cancer Hospital of Shantou University Medical College, Shantou

06120

ACTIVE_NOT_RECRUITING

Krankenhaus Martha-Maria Halle Dölau, Halle

00144

ACTIVE_NOT_RECRUITING

Regina Elena Institute for Cancer Research, Rome

277-0882

RECRUITING

National Cancer Center Hospital East, Chiba

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center, Ehime

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

830-0011

RECRUITING

Kurume University Hospital, Fukuoka

670-8520

RECRUITING

National Hospital Organization Himeji Medical Center, Hyōgo

673-8558

RECRUITING

Hyogo Cancer Center, Hyōgo

920-8641

RECRUITING

Kanazawa University Hospital, Ishikawa

241-0815

RECRUITING

Kanagawa Cancer Center, Kanagawa

981-0914

ACTIVE_NOT_RECRUITING

Sendai Kousei Hospital, Miyagi

951-8566

RECRUITING

Niigata Cancer Center Hospital, Niigata

545-8586

RECRUITING

Osaka Metropolitan University Hospital, Osaka

569-8686

RECRUITING

Osaka Medical and Pharmaceutical University Hospital, Osaka

589-8511

ACTIVE_NOT_RECRUITING

Kindai University Hospital, Osaka

591-8555

RECRUITING

National Hospital Organization Kinki Chuo Chest Medical Center, Osaka

350-1298

RECRUITING

Saitama Medical University, Saitama

4818 CK

ACTIVE_NOT_RECRUITING

Amphia Ziekenhuis, Breda

6716 RP

RECRUITING

Ziekenhuis Gelderse Vallei, Ede

9713 GZ

ACTIVE_NOT_RECRUITING

Universitair Medisch Centrum Groningen, Groningen

3844 DG

ACTIVE_NOT_RECRUITING

Ziekenhuis St Jansdal, Harderwijk

1400-038

RECRUITING

Fundacao Champalimaud, Lisbon

2674-514

RECRUITING

Hospital Beatriz Angelo. Hospital de Loures., Lisbon

4202-451

WITHDRAWN

Centro Hospitalar Universitario Sao Joao, EPE, Porto

4464-513

RECRUITING

Unidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano SA, Senhora da Hora

07061

WITHDRAWN

SMG - SNU Boramae Medical Center, Dongjak-Gu

361-711

RECRUITING

Chungbuk National University Hospital, Heungdeok-Gu

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

05505

WITHDRAWN

Asan Medical Center, Seoul

06591

RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

08036

ACTIVE_NOT_RECRUITING

Hospital Clinic de Barcelona, Barcelona

08041

ACTIVE_NOT_RECRUITING

Hospital de la Santa Creu i de Sant Pau, Barcelona

500-06

RECRUITING

Changhua Christian Hospital, Changhua

06550

ACTIVE_NOT_RECRUITING

Ankara Bilkent Sehir Hastanesi, Ankara

CO4 5JL

WITHDRAWN

Colchester General Hospital, Colchester

EC1A 7BE

ACTIVE_NOT_RECRUITING

St Bartholomew's Hospital, Barts Health NHS Trust, London

M20 4BX

WITHDRAWN

The Christie NHS Foundation Trust, Department of Medical Oncology, Manchester

SO16 6YD

WITHDRAWN

University Hospital Southampton Nhs Foundation Trust, Southampton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Arcus Biosciences, Inc.

INDUSTRY

lead

Gilead Sciences

INDUSTRY