Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

169

Participants

Timeline

Start Date

February 8, 2021

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Non Small Cell Lung CancerNonsquamous Non Small Cell Lung CancerSquamous Non Small Cell Lung CancerLung Cancer
Interventions
DRUG

Domvanalimab

Domvanalimab is a humanized monoclonal antibody targeting human TIGIT

DRUG

Zimberelimab

Zimberelimab is a fully human anti-PD-1 monoclonal antibody

DRUG

Carboplatin

Participants receive carboplatin, pemetrexed, and paclitaxel at a target area under the curve.

DRUG

Paclitaxel

Participants receive carboplatin, pemetrexed, and paclitaxel at a target area under the curve.

DRUG

Pemetrexed

Participants receive carboplatin, pemetrexed, and paclitaxel at a target area under the curve.

DRUG

Pembrolizumab

Pembrolizumab is a humanized Immunoglobulin G4 monoclonal antibody targeting the PD-1 receptor

Trial Locations (92)

60521

Hope and Healing Cancer Service, Hinsdale

Unknown

General hospital of Athens, chest diseases Sotiria, Athens

"University General Hospital Attikon", Chaïdári

"General Oncology Hospital of Kifissia Agioi Anargyroi", Kifissia

General Hospital of Patra Agios Andreas, Pátrai

Hong Kong Integrated Oncology Centre, Hong Kong

Hong Kong United Oncology Centre, Hong Kong

Humanity and Health Clinical Trial Centre, Hong Kong

Princess Margaret Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

Hospital Sultan Ismail, Johor Bahru

Hospital Kuala Lumpur, Kuala Lumpur

Pantai Hospital Kuala Lumpur, Kuala Lumpur

Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur

University Malaya Medical Centre, Kuala Lumpur

Hospital Tengku Ampuan Afzan, Kuantan

Hospital Umum Sarawak, Kuching

Hospital Pulau Pinang, Pulau Pinang

Mount Miriam Cancer Hospital, Pulau Pinang

Institut Kanser Negara, Putrajaya

Health Pharma Professional Research, Benito Juárez

Hospital Civil Fray Antonio Alcalde, Guadalajara

Chong Hua Hospital, Cebu

Metro Davao Medical and Research Centre, Davao City

Makati Medical Centre, Manila

Philippine General Hospital, Manila

St. Luke Medical Centre Quezon City, Quezon City

Exellentis Clinical Trial Consultants, George

Cancercare PE, Johannesburg

The Medical Oncology Centre of Rosebank, Johannesburg

Wits Clinical Research CMJAH Clinical Trial Site, Johannesburg

Port Elizabeth Oncology Centre-Cancercare, Port Elizabeth

University of Pretoria Medical Oncology, Pretoria

Wilgers Oncology Centre, Pretoria

Dong-A University Hospital, Busan

Kosin University Gospel Hospital, Busan

Keimyung University Dongsan Hospital, Daegu

Gachon University Gil Medical Center, Incheon

Inha University Hospital, Incheon

The Catholic University of Korea Incheon St. Mary's Hospital, Incheon

Jeonbuk National University Hospital, Jeonju

Gyeongsang National University Hospital, Jinju

Cha University Bundang Medical Center, Seongnam

Asan Medical Center, Seoul

Gangnam Severance Hospital Yonsei University Health System, Seoul

Kangbuk Samsung Hospital, Seoul

Korea University Anam Hospital, Seoul

Samsung Medical Center, Seoul

The Catholic University of Korea Eunpyeong St. Mary's Hospital, Seoul

Ajou University Hospital., Suwon

The Catholic University of Korea St. Vincent Hospital, Suwon

Pusan National University Yangsan Hospital, Yangsan

Chang Gung Medical Foundation Kaohsiung, Kaohsiung City

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

China Medical University Hospital, Taichung

Chung Shan Medical University Hospital, Taichung

Taipei Medical University Hospital, Taipei

King Chulalongkorn Memorial Hospital, Bangkok

Phramongkutklao Hospital, Bangkok

Police General Hospital, Bangkok

Rajavithi Hospital, Bangkok

Siriraj Hospital, Bangkok

Vajira Hospital, Bangkok

Saraburi Hospital, Changwat Sara Buri

Prapokklao Hospital, Chanthaburi

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

Nakornping Hospital, Chiang Mai

Srinagarind Hospital, Khon Kaen

Lampang Hospital, Lampang

HRH Princess Maha Chakri Sirindhorn Medical Centre, Nakhon Nayok

Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima

Buddhachinaraj Phitsanulok Hospital, Phitsanulok

Naresuan University Hospital, Phitsanulok

Songkhlanagarind Hospital, Songkhla

Sunpasitthiprasing Hospital, Ubon Ratchathani

Udon Thani Hospital, Udon Thani

Adana City Hospital, Adana

Ankara City Hospital, Adana

Gazi University Medical Faculty, Ankara

Memorial Ankara Hospital, Ankara

Gazi University Medical Faculty, Çankaya

Trakya University Medical Faculty, Edirne

Acibadem Atakent Hospital, Istanbul

Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul

Medipol University Medical Facility, Istanbul

Medipol University Medical Faculty, Istanbul

Kocaeli Universitesi Tip Fakultesi, Kocaeli

Kocaeli Universitiesi Tip Fakultesi, Kocaeli

Dicle University, Medical faculty, Sur

103 Military Hospital, Hanoi

National Lung Hospital, Hanoi

Hue Central Hospital, Huế

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Arcus Biosciences, Inc.

INDUSTRY