A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

196

Participants

Timeline

Start Date

November 6, 2019

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Advanced Pancreatic Cancer
Interventions
DRUG

AB680

AB680 is a Cluster of Differentiation (CD)73 Inhibitor.

DRUG

Zimberelimab

Zimberelimab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody targeting human PD-1.

DRUG

Nab-paclitaxel

Nab-paclitaxel is a chemotherapy agent. Chemotherapy agents are medicines that kill cancer cells.

DRUG

Gemcitabine

Gemcitabine is a chemotherapy agent. Chemotherapy agents are medicines that kill cancer cells.

Trial Locations (16)

10016

NYU Cancer Institute, New York

10032

Columbia University, New York

10065

Memorial Sloan Kettering Cancer Center, New York

15232

UPMC Hillman Cancer Center, Pittsburgh

19104

University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

33322

BRCR Global, Plantation

37203

Sarah Canon Research Institute, Nashville

53792

UW Health - UW Carbone Cancer Center - Medical Oncology Clinic, Madison

63110

Washington University School of Medicine - Siteman Cancer Center, St Louis

73104

Stephenson Cancer Center, Oklahoma City

77030

The University of Texas MD Anderson Cancer Center, Houston

78229

START San Antonio, San Antonio

90025

The Angeles Clinic, Los Angeles

90404

UCLA Hematology Oncology, Santa Monica

06520

Yale Cancer Center, New Haven

Sponsors
All Listed Sponsors
lead

Arcus Biosciences, Inc.

INDUSTRY