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Clinical Trials for Amgen
Explore 203 clinical trials worldwide
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Showing 1-50 of 203 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Amgen
Clinical Trials (203)
NCT07176546
TAVNEOS for Otolaryngologic Manifestations of Granulomatosis With Polyangiitis
PHASE2/PHASE3
Not yet recruiting
30 participants
Started: Jul 31, 2026 · Completed: Oct 31, 2030
3 conditions
2 sponsors
2 locations
NCT07203053
A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2
PHASE2
Not yet recruiting
48 participants
Started: May 31, 2026 · Completed: Oct 31, 2029
1 condition
2 sponsors
0 locations
NCT07153796
A Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Combination With Low Intensity Chemotherapy in Older Patients With Newly Diagnosed B-cell Acute Lymphoblastic Leukemia
PHASE2
Not yet recruiting
60 participants
Started: Feb 28, 2026 · Completed: Sep 30, 2033
1 condition
2 sponsors
1 location
NCT07192237
Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Patients With Measurable Residual Disease Positive B-cell Acute Lymphoblastic Leukemia
PHASE2
Not yet recruiting
40 participants
Started: Feb 27, 2026 · Completed: Oct 12, 2032
3 conditions
2 sponsors
1 location
NCT07178912
Phase II Study of the Combination of Subcutaneous Blinatumomab and Olverembatinib in Patients With Philadelphia Chromosome (ph)-Positive and/or BCR::ABL1 Positive Acute Lymphoblastic Leukemia (ALL)
PHASE2
Not yet recruiting
60 participants
Started: Feb 27, 2026 · Completed: Sep 30, 2031
5 conditions
3 sponsors
1 location
NCT06081153
Mechanistic Clinical Trial of PCSK9 Inhibition for AAA
EARLY_PHASE1
Not yet recruiting
44 participants
Started: Feb 1, 2026 · Completed: Jan 31, 2028
1 condition
3 sponsors
0 locations
NCT06967987
Study Evaluating the Combination of Bemarituzumab + FLOT Chemotherapy in Perioperative Setting for Resectable Stage cT2-T4a or N+ Gastric and GEJ Adenocarcinoma Overexpressing FGFR2b
PHASE2
Not yet recruiting
49 participants
Started: Dec 30, 2025 · Completed: Jun 30, 2034
2 conditions
2 sponsors
12 locations
NCT07134088
A Study of Subcutaneous Blinatumomab in Children With R/R and and MRD+ B-Cell Precursor Acute Lymphoblastic Leukemia
PHASE1/PHASE2
Not yet recruiting
104 participants
Started: Nov 21, 2025 · Completed: Jun 18, 2030
2 conditions
1 sponsor
0 locations
NCT07213674
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
PHASE3
Recruiting
750 participants
Started: Nov 1, 2025 · Completed: Aug 30, 2032
1 condition
1 sponsor
4 locations
NCT07102394
Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1
PHASE1
Not yet recruiting
10 participants
Started: Nov 1, 2025 · Completed: Dec 31, 2027
6 conditions
3 sponsors
1 location
NCT07172919
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation
PHASE2
Not yet recruiting
14 participants
Started: Oct 20, 2025 · Completed: Oct 20, 2027
1 condition
1 sponsor
0 locations
NCT07140900
Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer
PHASE1
Recruiting
60 participants
Started: Oct 7, 2025 · Completed: Mar 30, 2030
1 condition
1 sponsor
4 locations
NCT07037758
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
PHASE1
Recruiting
380 participants
Started: Sep 16, 2025 · Completed: Jan 4, 2031
1 condition
2 sponsors
4 locations
NCT06814496
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
PHASE1/PHASE2
Recruiting
30 participants
Started: Sep 8, 2025 · Completed: May 31, 2030
11 conditions
2 sponsors
1 location
NCT07061080
Refractory Advanced diGestive Neuroendocrine Carcinomas Treated With tARlatamab
PHASE2
Not yet recruiting
87 participants
Started: Aug 31, 2025 · Completed: Dec 31, 2028
2 conditions
2 sponsors
19 locations
NCT06987539
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)
PHASE2
Not yet recruiting
15 participants
Started: Aug 29, 2025 · Completed: Jan 4, 2030
1 condition
1 sponsor
0 locations
NCT07142642
A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Teprotumumab (AMG 632) Administered Intravenously in Healthy Chinese Participants
PHASE1
Active, not recruiting
20 participants
Started: Aug 26, 2025 · Completed: Nov 22, 2025
1 condition
1 sponsor
1 location
NCT07136012
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
PHASE3
Recruiting
11,000 participants
Started: Aug 22, 2025 · Completed: Oct 20, 2031
1 condition
1 sponsor
138 locations
NCT06776250
Study of How Safe and Effective Tarlatamab is in Brain Cancers
PHASE2
Recruiting
44 participants
Started: Aug 18, 2025 · Completed: Mar 3, 2028
2 conditions
2 sponsors
1 location
NCT07005128
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
PHASE3
Recruiting
330 participants
Started: Aug 18, 2025 · Completed: Jul 15, 2029
2 conditions
2 sponsors
53 locations
NCT07143513
Real World Evaluation of Sotorasib Among Chinese Non-Small Cell Lung Cancer Patients
N/A
Recruiting
115 participants
Started: Aug 11, 2025 · Completed: Jun 30, 2026
1 condition
1 sponsor
3 locations
NCT07160257
A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus
PHASE1
Recruiting
70 participants
Started: Aug 5, 2025 · Completed: Dec 13, 2026
1 condition
1 sponsor
1 location
NCT07094113
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
PHASE1
Recruiting
434 participants
Started: Jul 31, 2025 · Completed: Sep 9, 2030
1 condition
1 sponsor
4 locations
NCT07111507
A Study of Tarlatamab for People With Prostate Cancer
PHASE2
Recruiting
32 participants
Started: Jul 31, 2025 · Completed: Aug 31, 2027
1 condition
2 sponsors
7 locations
NCT07037433
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
PHASE3
Recruiting
12,800 participants
Started: Jul 25, 2025 · Completed: Sep 29, 2030
3 conditions
1 sponsor
162 locations
NCT07013578
TIDHI Mental Health in IBD Patients Study
NA
Recruiting
100 participants
Started: Jul 22, 2025 · Completed: Jul 1, 2027
3 conditions
3 sponsors
1 location
NCT06570798
A Phase 2a Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
PHASE2
Recruiting
98 participants
Started: Jul 16, 2025 · Completed: Jun 23, 2029
2 conditions
1 sponsor
44 locations
NCT06973109
Romosozumab Effects on Bone Density, Muscle Mass, and Spine Surgery Outcomes
PHASE2
Not yet recruiting
36 participants
Started: Jun 30, 2025 · Completed: Jun 30, 2027
1 condition
3 sponsors
1 location
NCT07037459
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
PHASE3
Recruiting
5,056 participants
Started: Jun 25, 2025 · Completed: Sep 29, 2030
3 conditions
1 sponsor
199 locations
NCT07016230
Study Investigating Tarlatamab (AMG 757) in Patients With Metastatic/Locally Advanced Small-Cell Lung Cancer (SCLC) and Other Poorly Differentiated Neuroendocrine Carcinomas (NECs), With Biomarker Analysis to Characterize Response/Resistance (UNLOCK TARLATAMAB)
PHASE2
Recruiting
40 participants
Started: Jun 24, 2025 · Completed: Jan 15, 2030
3 conditions
2 sponsors
1 location
NCT06987695
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants in Japan Who Have Obesity Disease
PHASE3
Recruiting
272 participants
Started: Jun 13, 2025 · Completed: Oct 19, 2027
1 condition
1 sponsor
30 locations
NCT06588153
A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With Glucocorticoid-induced Osteoporosis in Mainland China
PHASE4
Recruiting
100 participants
Started: May 24, 2025 · Completed: May 24, 2027
1 condition
1 sponsor
10 locations
NCT06898957
Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)
PHASE1
Recruiting
200 participants
Started: May 16, 2025 · Completed: Apr 23, 2031
1 condition
2 sponsors
15 locations
NCT06816394
Tarlatamab for Advanced Extrapulmonary Small Cell Carcinoma and Neuroendocrine Carcinoma (TAURUS)
PHASE2
Not yet recruiting
32 participants
Started: May 15, 2025 · Completed: Apr 30, 2029
1 condition
2 sponsors
1 location
NCT06910709
Single and Multiple Ascending Dose Study of AMG 378 in Healthy Participants
PHASE1
Recruiting
92 participants
Started: Apr 8, 2025 · Completed: Oct 4, 2028
1 condition
1 sponsor
2 locations
NCT06878261
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
PHASE3
Recruiting
990 participants
Started: Mar 25, 2025 · Completed: Jun 5, 2029
1 condition
2 sponsors
260 locations
NCT06788938
Tarlatamab in Advanced Delta-like 3 (DLL3)-Expressing Tumors Including Neuroendocrine Neoplasms
PHASE2
Recruiting
29 participants
Started: Mar 21, 2025 · Completed: Apr 24, 2029
2 conditions
2 sponsors
5 locations
NCT06883305
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD
PHASE3
Recruiting
990 participants
Started: Mar 18, 2025 · Completed: Jun 5, 2029
1 condition
2 sponsors
292 locations
NCT06858878
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
PHASE3
Active, not recruiting
1,105 participants
Started: Mar 17, 2025 · Completed: Apr 25, 2027
1 condition
1 sponsor
187 locations
NCT06858839
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
PHASE3
Active, not recruiting
3,853 participants
Started: Mar 12, 2025 · Completed: Apr 16, 2027
1 condition
1 sponsor
243 locations
NCT06680622
Bemarituzumab in FGFR2b+ Patients With Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction, Who Failed at Least One Prior Line of Palliative Chemotherapy
PHASE2
Recruiting
126 participants
Started: Mar 3, 2025 · Completed: Mar 31, 2028
1 condition
4 sponsors
35 locations
NCT06660810
Neoadjuvant Intralesional Injection of Talimogene Laherparepvec
PHASE2
Active, not recruiting
2 participants
Started: Mar 3, 2025 · Completed: Mar 31, 2030
2 conditions
2 sponsors
1 location
NCT06745323
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC
PHASE2
Recruiting
240 participants
Started: Feb 26, 2025 · Completed: Feb 13, 2029
1 condition
1 sponsor
75 locations
NCT06747949
A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)
PHASE3
Recruiting
844 participants
Started: Feb 25, 2025 · Completed: Aug 26, 2029
1 condition
1 sponsor
74 locations
NCT06807619
A Study of Sotorasib in People With Brain Tumors
PHASE1
Recruiting
16 participants
Started: Jan 29, 2025 · Completed: Jan 31, 2028
1 condition
2 sponsors
7 locations
NCT06533748
Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma
PHASE2
Recruiting
128 participants
Started: Jan 23, 2025 · Completed: May 31, 2034
2 conditions
3 sponsors
2 locations
NCT06700343
Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)
PHASE3
Recruiting
444 participants
Started: Jan 13, 2025 · Completed: Dec 17, 2027
1 condition
1 sponsor
38 locations
NCT06649006
Study to Investigate Intravenous Blinatumomab in Japanese Adult Participants With Newly Diagnosed Philadelphia-negative B-precursor Acute Lymphoblastic Leukemia (B-ALL)
PHASE1
Active, not recruiting
6 participants
Started: Jan 8, 2025 · Completed: Dec 15, 2025
1 condition
1 sponsor
6 locations
NCT06593522
A Phase 2 Study of AMG 193 in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
PHASE2
Recruiting
200 participants
Started: Dec 26, 2024 · Completed: Sep 11, 2029
1 condition
1 sponsor
87 locations
NCT06691984
Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)
PHASE3
Recruiting
675 participants
Started: Dec 9, 2024 · Completed: Jul 30, 2029
1 condition
1 sponsor
147 locations
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