A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

PHASE3RecruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

August 18, 2025

Primary Completion Date

January 4, 2029

Study Completion Date

July 15, 2029

Conditions
Small-cell Lung CancerExtensive Stage Small-cell Lung Cancer
Interventions
DRUG

Tarlatamab

Tarlatamab will be administered as an intravenous (IV) infusion.

DRUG

Durvalumab

Durvalumab will be administered as an IV infusion.

DRUG

Carboplatin

Carboplatin will be administered as an IV infusion.

DRUG

Etoposide

Etoposide will be administered as an IV infusion.

Trial Locations (53)

1211

RECRUITING

Hopitaux universitaires de Geneve, Geneva

2045

RECRUITING

Reformatus Pulmonologiai Centrum, Törökbálint

2050

RECRUITING

Chris OBrien Lifehouse, Camperdown

2100

RECRUITING

Rigshospitalet, Copenhagen

3168

RECRUITING

Monash Medical Centre, Clayton

3200

RECRUITING

Matrai Gyogyintezet, Gyöngyös

3500

RECRUITING

Universitaetsklinikum Krems, Krems

4052

RECRUITING

Universitaetsspital Basel, Basel

7400

RECRUITING

Regionshospitalet Godstrup, Herning

10408

RECRUITING

National Cancer Center, Goyang-si Gyeonggi-do

11217

RECRUITING

Taipei Veterans General Hospital, Taipei

22927

RECRUITING

LungenClinic Grosshansdorf GmbH, Großhansdorf

26506

RECRUITING

West Virginia University Health Sciences Center, Morgantown

28644

RECRUITING

Chungbuk National University Hospital, Cheongju Chungbuk

34214

RECRUITING

Bagcilar Medipol Mega Universite Hastanesi, Istanbul

34722

RECRUITING

Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul

37126

RECRUITING

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona

38120

RECRUITING

Baptist Cancer Center, Memphis

44800

RECRUITING

Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec, Saint-Herblain

47014

RECRUITING

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori, Meldola (FC)

54290

RECRUITING

Sakarya Egitim ve Arastirma Hastanesi, Sakarya

57001

RECRUITING

European Interbalkan Medical Center, Thessaloniki

RECRUITING

Iatriko Diavalkaniko Thessalonikis, Thessaloniki

70124

RECRUITING

IRCCS Istituto Tumori Giovanni Paolo II, Bari

70403

RECRUITING

National Cheng Kung University Hospital, Tainan City

97078

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

100080

RECRUITING

Beijing Cancer Hospital, Beijing

100142

RECRUITING

Beijing Cancer Hospital, Beijing

154007

RECRUITING

Jiamusi Cancer Hospital, Jiamusi

200030

RECRUITING

Shanghai Chest Hospital, Shanghai

250117

RECRUITING

Shandong Cancer Hospital, Jinan

300060

RECRUITING

Tianjin Cancer Hospital, Tianjin

315010

RECRUITING

The First Affiliated Hospital Of Ningbo University, Ningbo

330029

RECRUITING

Jiangxi Cancer hospital, Nanchang

330209

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

350011

RECRUITING

Fujian Cancer Hospital, Fuzhou

362002

RECRUITING

The Second Attached Hospital Of Fujian Medical University, Quanzhou

030009

RECRUITING

Shanxi Provincial Cancer Hospital, Taiyuan

Unknown

RECRUITING

Queen Mary Hospital, The University of Hong Kong, Hong Kong

RECRUITING

Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories

00184

RECRUITING

Azienda Ospedaliera San Giovanni Addolorata, Roma

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

830-0011

RECRUITING

Kurume University Hospital, Kurume-shi

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

673-8558

RECRUITING

Hyogo Cancer Center, Akashi-shi

700-8558

RECRUITING

Okayama University Hospital, Okayama

573-1191

RECRUITING

Kansai Medical University Hospital, Hirakata-shi

350-1298

RECRUITING

Saitama Medical University International Medical Center, Hidaka-shi

641-8510

RECRUITING

Wakayama Medical University Hospital, Wakayama

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

08035

RECRUITING

Hospital Universitari Vall d Hebron, Barcelona

06520

RECRUITING

Memorial Ankara Hastanesi, Ankara

06800

RECRUITING

Ankara Bilkent Sehir Hastanesi, Ankara

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Amgen

INDUSTRY