Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,105

Participants

Timeline

Start Date

March 17, 2025

Primary Completion Date

January 30, 2027

Study Completion Date

April 25, 2027

Conditions
Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Interventions
DRUG

Maridebart cafraglutide

Maridebart cafraglutide will be adminstered SC.

DRUG

Placebo

Placebo will be adminstered SC.

Trial Locations (187)

1033

Clinexpert Kft, Budapest

1036

Obudai Egeszsegugyi Centrum Kft, Budapest

1089

ClinDiab Kft, Budapest

1120

Centro Medico Viamonte, CABA

1132

MED-TIMA Kft, Budapest

1404

Diagnostic - Consultative Center XX - Sofia EOOD, Sofia

1407

Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD, Sofia

1750

University Multiprofile Hospital for Active Treatment Sofiamed OOD, Sofia

2900

Komaromi Selye Janos Korhaz, Komárom

4025

Borvo Clinic Kft, Debrecen

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4405

Borbanya Praxis Egeszsegugyi Kft, Nyíregyháza

5801

Ambulatory for specialized outpatient medical aid in endocrinology-Dr Albena Dinkova EOOD, Pleven

6000

Prevencia-2000-Medical center for outpatient medical aid OOD, Stara Zagora

6500

Lausmed Kft, Baja

8230

DRC Gyogyszervizsgalo Kozpont Kft, Balatonfüred

8600

Medical Center Berbatov EOOD, Yambol

9700

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz, Szombathely

10117

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin

10787

Velocity Clinical Research GmbH, Berlin

12203

Albany Medical College, Albany

13187

Diabetespraxis Dr. Hermann Braun, Berlin

13597

Mvz am Bahnhof Spandau, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

14612

Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin, Falkensee

15355

Korea University Ansan Hospital, Ansan-si, Gyeonggi-do

20110

Manassas Clinical Research Center Inc, Manassas

20122

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan

20138

IRCCS Centro Cardiologico Monzino, Milan

20157

Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan

21401

Annapolis Internal Medicine, LLC, Annapolis

22607

Diabeteszentrum Hamburg West, Hamburg

22767

Endokrinologikum Hamburg, Hamburg

23758

Red-Institut GmbH, Oldenburg

26426

Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon-do

26505

Ima Clinical Research - West Virginia, Morgantown

27834

Physicians East, Greenville

28557

Carteret Medical Group, Morehead City

West Clinical Research, Morehead City

28803

Asheville Clinical Research, Asheville

32545

Universitaetsklinikum der Ruhr-Universitaet Bochum, Bad Oeynhausen

32789

Conquest Research - Winter Park, Winter Park

32825

Florida Institute for Clinical Research, Orlando

33012

Indago Research and Health Center, Hialeah

33014

San Marcus Research Clinic Inc, Miami Lakes

33135

Optimus U Corporation, Miami

33165

New Horizon Research Center, Miami

33331

Encore Medical Research of Weston LLC, Weston

36608

Alliance for Multispecialty Research Mobile, Mobile

37643

Medical Care LLC, Elizabethton

40138

IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola, Bologna

42001

Advanced Internal Medicine, Paducah

42415

Yeungnam University Medical Center, Daegu

45136

InnoDiab Forschung, Essen

45242

Velocity Clinical Research - Cincinnati, Blue Ash

45246

Velocity Clinical Research - Springdale, Cincinnati

46410

Indiana Medical Research Institute, Merrillville

48145

Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster, Münster

50134

Azienda Ospedaliero Universitaria Careggi, Florence

50266

Iowa Diabetes Research, West Des Moines

52074

Universitatsklinikum Aachen, Aachen

55416

International Diabetes Center - HealthPartners Institute, Minneapolis

60077

Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie, Skokie

60523

Alliance For Multispecialty Research - Oak Brook, Oak Brook

64114

Alliance for Multispecialty Research - Kansas City, Kansas City

66068

Alliance for Multispecialty Research, LLC - Park Ridge, Park Ridge

66100

Universita degli Studi Gabriele D Annunzio di Chieti e Pescara, Chieti

67114

Alliance for Multispecialty Research Newton, Newton

67207

Alliance for Multispecialty Research LLC, Wichita

71201

Ima Clinical Research- Monroe, Monroe

75020

Soma Clinical Trials, LLC, Denison

75069

Tekton Research, McKinney

75251

Cedar Health Research, LLC, Dallas

76040

Cedar Health Research, LLC, Euless

77040

Juno Research LLC, Houston

77054

Juno Research LLC, Houston

78233

Northeast Clinical Research of San Antonio LLC, San Antonio

78414

Osvaldo A Brusco MD PA, Corpus Christi

78701

Elligo Clinical Research Center, Austin

79189

Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen

80809

Centrum für Diagnostik und Gesundheit, München

84041

Alliance for Multispecialty Research - Layton, Layton

85044

Avacare Foothills Research Center, Phoenix

85213

Desert Clinical Research, Mesa

85296

Gilbert Center for Family Medicine, Gilbert

89128

Palm Research Center Inc, Las Vegas

89436

Vector Clinical Trials, Sparks

90127

Ospedale Civico, Di Cristina e Benfratelli, Palermo

90703

Core Healthcare Group, Cerritos

91304

San Fernando Valley Health Institute, Canoga Park

91325

Flourish Research, Northridge

91767

Empire Clinical Research, Pomona

91911

Velocity Clinical Research Chula Vista, Chula Vista

92025

Headlands Research California, Escondido

92108

Infinity Clinical Trials, San Diego

92868

University of California Irvine, Orange

95355

Paradigm Clinical Research, Modesto

97980

Diabetespraxis Bad Mergentheim, Bad Mergentheim

98108

VA Puget Sound Healthcare System, Seattle

06878

Greenwich Clinical Trials, Riverside

02115

Brigham and Womens Hospital, Boston

08611

Premier Research, Trenton

02818

Velocity Clinical Research - Providence, East Greenwich

C1060ABN

Cedic Centro de Investigacion Clinica, CABA

C1407GTN

Cemedic Centro de Especialidades Medicas, CABA

C1425AGC

Maffei Centro Medico, CABA

C1426ABP

Consultorios Medicos Dr Besada, CABA

C1056ABI

Cinme - Centro de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires

C1061AAT

Ciprec Centro de Investigacion y Prevencion Cardiovascular, Ciudad Autonoma de Buenos Aires

V3T 2V6

tlc Diabetes and Endocrinology, Surrey

R2V 3M3

Chronic Disease Innovation Centre, Winnipeg

B3H 2Y9

Nova Scotia Health Authority, Queen Elizabeth ii Health Sciences Centre, Halifax

L6S 0C6

Centricity Research Brampton, Brampton

L6T 0G1

Aggarwal and Associates Ltd, Brampton

L4K 4M2

Centricity Research Vaughan, Concord

L8J 0B6

Winterberry Family Medicine, Hamilton

L8L 5G4

Premier Clinical Trial Network, Hamilton

N5W 6A2

Milestone Research, London

K2J 0V2

Centricity Research Ottawa LMC, Nepean

L2H 1H5

Your Research Network Inc., Niagara Falls

M6B 3H7

North York Diagnostic and Cardiac Centre, North York

N7T 4X3

Bluewater Clinical Research Group Incorporated, Sarnia

M9V 4B4

Albion Finch Medical Centre, Toronto

G6W 0M5

Centricity Research Quebec City, Lévis

H2W 1R7

Institut de recherches cliniques de Montreal, Montreal

H4N 2W2

Centre Medical Acadie, Montreal

H9R 4S3

Centricity Research Pointe-Claire, Pointe-Claire

G9A 4P3

Diex Recherche Trois Rivieres, Trois-Rivières

625 00

Fakultni nemocnice Brno, Brno

702 00

CCR Ostrava sro, Ostrava

530 02

Diahelp sro, Pardubice

Pratia Pardubice as, Pardubice

100 34

Fakultni nemocnice Kralovske Vinohrady, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Prague

140 21

Institut klinicke a experimentalni mediciny, Prague

149 00

Milan Kvapil sro, Prague

181 00

Restrial sro, Prague

198 00

Endokrinologie Cerny Most sro, Prague

261 01

Milan Kvapil sro, Pribram VIII

04910

Zentrum fuer Klinische Studien Suedbrandenburg GmbH, Elsterwerda

06679

Diabetologische Schwerpunktpraxis Hohenmoelsen, Hohenmölsen

04103

Universitaetsklinikum Leipzig, Leipzig

04107

AmBeNet GmbH, Leipzig

04416

Kardiologische Praxis Doktor Jens Taggeselle, Markkleeberg

790-0034

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism, Matsuyama

807-0072

Morizono Medical Clinic, Kitakyusyu-shi

735-8585

Mazda Hospital of Mazda Motor Corporation, Aki-gun

310-0826

Nakamoto Medical Clinic, Mito

311-0113

Nakakinen Clinic, Naka

300-0835

Ohishi Naika Clinic, Tsuchiura-shi

860-0863

Morinaga Ueno Clinic, Kumamoto

582-0005

Shiraiwa Medical Clinic, Kashiwara-shi

424-0855

Suruga Clinic, Shizuoka

153-0053

Yutenji Medical Clinic, Meguro-ku

181-0013

Medical Corporation Ouitsukai Kanno Naika, Mitaka-shi

40-772

Salvia-Lekston i Madej Spolka Jawna, Katowice

90-338

Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna, Lodz

20-011

Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski, Lublin

20-718

Ekamed Spolka z Ograniczona Odpowiedzialnoscia, Lublin

32-600

Medicome Spolka z Ograniczona Odpowiedzialnoscia, Oświęcim

24-100

Velocity Nova Sp zoo Velocity Pulawy, Puławy

41-709

NZOZ Przychodnia Specjalistyczna A Wittek H Rudzki spolka jawna, Ruda Śląska

28-200

Velocity Nova Sp zoo Velocity Staszow, Staszów

21-040

Tomasz Blicharski Lubelskie Centrum Diagnostyczne, Świdnik

00-710

Nbr Polska Tomasz Klodawski, Warsaw

02-507

Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji, Warsaw

51-685

Wromedica I Bielicka A Strzalkowska SC, Wroclaw

00909

Latin Clinical Trial Center, San Juan

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05278

KyungHee University Gangdong Hospital, Seoul

05505

Asan Medical Center, Seoul

06591

The Catholic University of Korea Seoul St Marys Hospital, Seoul

07441

Hallym University Kangnam Sacred Heart Hospital, Seoul

BT28BG

Ormeau Clinical Trials Ltd, Belfast

B21 9RY

FutureMeds Birmingham, Birmingham

FY3 7EN

Layton Medical Centre, Blackpool

FY4 3AD

Waterloo Medical Centre, Blackpool

BS10 5NB

Southmead Hospital, Bristol

CB7 5JD

Staploe Medical Centre, Ely

G20 7BE

FutureMeds Glasgow, Glasgow

HU3 2JZ

Hull Royal Infirmary, Hull

LE5 4PW

NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre, Leicester

L9 7AL

Aintree University Hospital, Liverpool

S65 1DA

Clifton Medical Centre, Rotherham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY