Study Evaluating the Combination of Bemarituzumab + FLOT Chemotherapy in Perioperative Setting for Resectable Stage cT2-T4a or N+ Gastric and GEJ Adenocarcinoma Overexpressing FGFR2b

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

December 30, 2025

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2034

Conditions
Gastric and Gastro-oesophageal Junction (GEJ) AdenocarcinomasOverexpression FGFR2b
Interventions
DRUG

Bemarituzumab + Flot regimen

"Bemarituzumab (IV administration) over 30 min (+/- 10min) at C1D1 to C8D1 + 15 mg/kg of bodyweight + single additional dose of 7,5 mg/kg at C1D8~\+ FLOT regimen~* Fluorouracil for solution for infusion (IV administration) as a continuous IV infusion approximately 24 hours 2600 mg/m²~* Leucovorin (folinic acid) solution for infusion (IV administration) over 120 min on the first day, 200 mg/m²~* Oxaliplatin concentrate for solution for infusion (IV administration) over 120 min on the first day, 85 mg/m²~* Docetaxel concentrated for solution for infusion (IV administration) over 60 min on the first day, 50 mg/m²"

Trial Locations (12)

13273

Institut Paoli Calmette, Marseille

14076

Centre François Baclesse, Caen

21079

Centre Georges François Leclerc, Dijon

29609

CHRU de Brest, Brest

33000

Institut Bergonié, Bordeaux

35000

CHU de Rennes, Rennes

44805

Institut de Cancérologie de l'Ouest, Saint-Herblain

49055

Institut de Cancérologie de l'Ouest, Angers

54519

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

69373

Centre Léon Bérard, Lyon

86021

CHU de Poitiers, Poitiers

94805

Gustave Roussy, Villejuif

All Listed Sponsors
collaborator

Amgen Ltd., United Kingdom

UNKNOWN

lead

Institut Cancerologie de l'Ouest

OTHER