Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

3,853

Participants

Timeline

Start Date

March 12, 2025

Primary Completion Date

January 21, 2027

Study Completion Date

April 16, 2027

Conditions
Obesity
Interventions
DRUG

Maridebart Cafraglutide

Maridebart cafraglutide will be administered SC.

DRUG

Placebo

Placebo will be administered SC.

Trial Locations (243)

1060

Cedic - Centro de Investigacion Clinica, CABA

1120

Centro Medico Viamonte, CABA

1211

Hopitaux Universitaires de Geneve, Geneva

2019

Emeritus Research Sydney, Botany

2065

Royal North Shore Hospital, St Leonards

2228

Canopy Clinical Sutherland, Miranda

2290

Novatrials, Charlestown

2500

Canopy Clinical Wollongong, Wollongong

2650

Universitair Ziekenhuis Antwerpen, Edegem

Hvidovre Hospital, Hvidovre

2730

Sanos Clinic, Herlev

Steno Diabetes Center Copenhagen, Herlev

2800

Algemeen Ziekenhuis Sint-Maarten, Mechelen

2900

Gentofte Hospital, Hellerup

3000

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven

3025

Canopy Clinical Altona North, North Altona

3081

Austin Health, Heidelberg Repatriation Hospital, Heidelberg West

3124

Emeritus Research Camberwell, Camberwell

4000

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège

4031

Universitaetsspital Basel, Basel

4131

Logan Hospital, Meadowbrook

5046

Southern Adelaide Diabetes and Endocrine Services, Oaklands Park

5067

Fusion Clinical Research, Norwood

7000

Centres Hospitaliers Universitaires HELORA - Hôpital de Mons - Site Constantinople, Mons

7400

Regionshospitalet Godstrup, Herning

8091

Universitaetsspital Zuerich, Zurich

8500

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk

9000

Universitair Ziekenhuis Gent, Ghent

9007

Kantonsspital Sankt Gallen, Sankt Gallen

9016

Stoffwechselzentrum Sankt Gallen, Sankt Gallen

9362

Sanos Gandrup, Gandrup

10117

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin

10326

Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do

10787

Velocity Clinical Research GmbH, Berlin

11540

Hospital Virgen del Camino, Sanlúcar de Barrameda

13187

Diabetespraxis Dr. Hermann Braun, Berlin

13597

Mvz am Bahnhof Spandau, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

13850

Velocity Clinical Research- Binghamton, Vestal

14068

Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do

14609

Rochester Clinical Research, Rochester

14612

Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin, Falkensee

14647

The Catholic University of Korea Bucheon St Marys Hospital, Bucheon, Gyeonggi-do

15006

Hospital Medico Quirurgico San Rafael, A Coruña

15355

Korea University Ansan Hospital, Ansan-si, Gyeonggi-do

16499

Ajou University Hospital, Suwon-si Gyeonggi-do

17074

Capital Area Research LLC, Newport

20138

IRCCS Centro Cardiologico Monzino, Milan

20157

Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milan

21007

Hospital Infanta Elena, Huelva

21565

Gachon University Gil Medical Center, Incheon

22206

Washington Center for Weight Management and Research, Inc, Arlington

22601

Selma Medical Associates, Winchester

22607

Diabeteszentrum Hamburg West, Hamburg

22767

Endokrinologikum Hamburg, Hamburg

23538

Universitaetsklinikum Schleswig-Holstein - Luebeck, Lübeck

23606

Health Research of Hampton Roads, Newport News

23758

Red-Institut GmbH, Oldenburg

27157

Wake Forest University Health Sciences, Winston-Salem

28150

Carolina Research Center Inc, Shelby

28223

Clinica Ruber SA, Pozuelo de Alarcón

28601

Accellacare of Hickory, Hickory

29607

Tribe Clinical Research LLC Dba Mountain View Clinical Research, Greenville

30291

Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group, Union City

30501

Center for Advanced Research and Education, Gainesville

31008

Clinica Universidad de Navarra, Pamplona

32216

Jacksonville Center for Clinical Research, Jacksonville

32256

Clinical Neuroscience Solutions - Jacksonville, Jacksonville

32545

Universitaetsklinikum der Ruhr-Universitaet Bochum, Bad Oeynhausen

32801

Clinical Neuroscience Solutions - Orlando, Orlando

32807

Combined Research Orlando Phase I IV, Orlando

32825

Florida Institute for Clinical Research, Orlando

33012

Indago Research and Health Center, Hialeah

33063

South Florida Wellness and Clinical Research Institute, Margate

33135

Optimus U Corporation, Miami

33173

Research Institute of South Florida, Miami

33331

Encore Medical Research of Weston LLC, Weston

34121

Braun Ambulantes Herzzentrum Kassel, Kassel

34470

Renstar Medical Research, Ocala

35233

Daejeon Eulji Medical Center, Eulji University, Daejeon

35365

Konyang University Hospital, Daejeon

36207

Pinnacle Research Group LLC, Anniston

36526

Alliance For Multispecialty Research - Daphne, Daphne

36608

Alliance for Multispecialty Research Mobile, Mobile

37909

New Phase Research and Development, Knoxville

37938

Accellacare US Inc., d/b/a Accellacare of Knoxville, Knoxville

39069

Prime Health and Wellness Sky Clinical Research Network Group, Fayette

40138

IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola, Bologna

40213

Louisville Metabolic and Atherosclerosis Research Center, Louisville

41003

Nuevas Tecnologias en Diabetes y Endocrinologia, Seville

41010

Hospital Quironsalud Infanta Luisa, Seville

41944

Kyungpook National University Hospital, Daegu

41950

Hospital Vithas Sevilla, Castilleja de la Cuesta

42415

Yeungnam University Medical Center, Daegu

45136

InnoDiab Forschung, Essen

45212

Clinical Trial Investigator Clinical Research Center, Cincinnati

45219

Velocity Clinical Research - Cincinnati, Cincinnati

45355

Praxis am Markt Dr. Bernd Becker, Essen

46017

Hospital Universitario Doctor Peset, Valencia

48034

Headlands Research - Detroit, Southfield

48145

Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster, Münster

49201

Dong-A University Hospital, Busan

50134

Azienda Ospedaliero Universitaria Careggi, Florence

50612

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnam-do

52074

Universitaetsklinikum Aachen, Aachen

53226

Allegiance Research Specialists, Milwaukee

55131

Marienhaus Klinikum Mainz, Mainz

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

60077

Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie, Skokie

Evanston Premier Healthcare Research LLC, Skokie

60596

ClinPhenomics CVC GmbH, Frankfurt am Main

60640

Flourish Research - Great Lakes Clinical Trials, Chicago

61348

Kardiologische Praxis Dr med Wolfgang Jungmair, Bad Homburg

64114

Alliance for Multispecialty Research - Kansas City, Kansas City

66100

Universita degli Studi Gabriele D Annunzio di Chieti e Pescara, Chieti

66386

Praxis Segner - Dr. Braun - Kirsch, Oberwürzbach

67114

Alliance for Multispecialty Research Newton, Newton

70072

Tandem Clinical Research - Marrero, Marrero

70211

Health Step Finland, Kuopio

70809

Velocity Clinical Research - Baton Rouge, Baton Rouge

73069

Alliance for Multispecialty Research - Norman, Norman

75115

Epic Medical Research - Texas, DeSoto

75149

Southern Endocrinology Associates PA, Mesquite

75251

Cedar Health Research, LLC, Dallas

76040

Cedar Health Research, LLC, Euless

77040

Juno Research LLC, Houston

77043

Biopharma Informatic, LLC, Houston

77054

Juno Research LLC, Houston

77479

Sugar Lakes Family Practice, Sugar Land

78048

Gemeinschaftspraxis Prof Jacob/ Dr Jacob, Villingen-Schwenningen

78229

Clinical Trials of Texas, San Antonio

78557

Great Lakes Research Institute - McAllen Research, Pharr

78704

Elligo Clinical Research Center, Austin

79189

Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen

79936

Great Lakes Research Institute El Paso Research, El Paso

80809

Centrum für Diagnostik und Gesundheit, München

83646

Solaris Clinical Research, Meridian

84010

Pantheon Clinical Research, Bountiful

84041

Alliance for Multispecialty Research Layton Research Center, Layton

84770

Chrysalis Clinical Research, LLC, St. George

85044

Avacare Foothills Research Center, Phoenix

88239

Zentrum fuer klinische Forschung Allgaeu Oberschwaben, Wangen

89128

Palm Research Center Inc, Las Vegas

Vector Clinical Trials, Las Vegas

90127

Ospedale Civico, Di Cristina e Benfratelli, Palermo

90220

Oulu University Hospital, Oulu

90806

Long Beach Clinical Trials Services Inc, Long Beach

90815

Ark Clinical Research- Long Beach, Long Beach

91763

Catalina Research Institute, Montclair

92103

Artemis Institute for Clinical Research, San Diego

92120

Apex Clinical Research, San Diego

92503

Artemis Institute for Clinical Research, Riverside

92701

Southern California Clinical Research, Santa Ana

92708

Ark Clinical Research- Tustin, Fountain Valley

94598

Diablo Clinical Research, Walnut Creek

96814

East-West Medical Research, Honolulu

97980

Diabetespraxis Bad Mergentheim, Bad Mergentheim

06520

Yale School of Medicine, New Haven

06708

Chase Medical Research LLC, Waterbury

02818

Velocity Clinical Research - Providence, East Greenwich

C1407GTN

Cemedic Centro de Especialidades Medicas, CABA

C1425AGC

Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada, CABA

C1426ABP

Consultorios Medicos Dr Besada, CABA

Fundacion Respirar, CABA

C1056ABI

Cinme - Centro de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires

C1061AAT

Ciprec - Centro de Investigacion y Prevencion Cardiovascular, Ciudad Autonoma de Buenos Aires

V3T 2V6

tlc Diabetes and Endocrinology, Surrey

L8L 5G8

Wharton Medical Clinic, Hamilton

M6B 3H7

North York Diagnostic and Cardiac Centre, North York

L1J 2K9

Centricity Research Oshawa Multispecialty, Oshawa

M1B 4Z8

Heart Health Institute Research Incorporated, Scarborough Village

P7B 5N3

Curans Heart Center, Thunder Bay

M4G 3E8

Centricity Research Toronto, Toronto

M6G 1M2

Diabetes Heart Research Centre, Toronto

G7H 7K9

Ecogene-21, Chicoutimi

G1V 4G5

Institut Universitaire de cardiologie et de pneumologie de Quebec, Québec

J3A 1J2

CardioVasc HR Incorporated, Saint-Jean-sur-Richelieu

J6X 4P7

Centre de Medecine Metabolique de Lanaudiere, Terrebonne

250 01

Medicus Services sro, Brandýs nad Labem

625 00

Fakultni nemocnice Brno, Brno

736 01

Endohope Havirov sro, Havířov

779 00

PreventaMed sro, Olomouc

702 00

CCR Ostrava sro, Ostrava

100 34

Fakultni nemocnice Kralovske Vinohrady, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Prague

130 00

Ob klinika as, Prague

140 21

Institut klinicke a experimentalni mediciny, Prague

150 00

Endohope klinika sro, Prague

198 00

Endokrinologie Cerny Most sro, Prague

02290

Obesity Research Unit, Helsinki

01307

Universitaetsklinikum Dresden, Dresden

04190

Zentrum fuer Klinische Studien Suedbrandenburg GmbH, Elsterwerda

06679

Diabetologische Schwerpunktpraxis Hohenmoelsen, Hohenmölsen

04103

Universitaetsklinikum Leipzig, Leipzig

04107

AmBeNet GmbH, Leipzig

04416

Kardiologische Praxis Doktor Jens Taggeselle, Markkleeberg

00133

Fondazione Policlinico Tor Vergata, Roma

231-0023

Medical Corporation Hitomikai Motomachi Takatsuka Naika Clinic, Yokohama

101-0041

Doujin Memorial Foundation, Meiwa Hospital, Chiyoda-ku

104-0031

Tokyo Asbo Clinic, Chuo-ku

192-0046

Medical Corp Seikoukai New Medical Research System Clinic, Hachioji-shi

108-0075

Medical Corporation AOT Shinagawa Strings Clinic, Minato-ku

160-0004

Clinical Research Hospital Tokyo, Shinjuku-ku

166-0003

Medical Corporation Hanabusakai Shinei Medical Healthcare Clinic, Suginami-ku

15-281

Gabinet Leczenia Otylosci i Chorob Dietozaleznych dr hab n med Lucyna Ostrowska, Bialystok

15-481

Kresmed Spolka z Ograniczona Odpowiedzialnoscia, Bialystok

39-200

Etg Lublin Spzoo, Dębica

81-384

Futuremeds Spolka z ograniczona odpowiedzialnoscia, Gdynia

40-752

Uniwersyteckie Centrum Kliniczne im Prof K Gibinskiego Slaskiego UM w Katowicach, Katowice

40-772

Salvia-Lekston i Madej Spolka Jawna, Katowice

90-338

Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna, Lodz

20-718

Ekamed Spolka z Ograniczona Odpowiedzialnoscia, Lublin

60-589

Centrum Zdrowia Metabolicznego Pawel Bogdanski, Poznan

61-731

Clinical Research Center Spzoo Medic-R Spolka Komandytowa, Poznan

00-215

Futuremeds Spolka z ograniczona odpowiedzialnoscia, Warsaw

00-710

Clinical Best Solutions Sp zoo Spolka komandytowa, Warsaw

00716

Ponce Medical School Foundation Inc, Ponce

00717

Puerto Rico Medical Research Inc., Ponce

00909

Latin Clinical Trial Center, San Juan

00694

Wellness Clinical Research Vega Baja, Vega Baja

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05278

KyungHee University Gangdong Hospital, Seoul

07061

Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul

07345

The Catholic University of Korea Yeouido St Marys Hospital, Seoul

04009

Centro Periferico de Especialidades Bola Azul, Almería

07014

Clinica Juaneda, Palma

BT28BG

Ormeau Clinical Trials Ltd, Belfast

B21 9RY

FutureMeds Birmingham, Birmingham

FY3 7EN

Layton Medical Centre, Blackpool

FY4 3AD

Waterloo Medical Centre, Blackpool

BS10 5NB

Southmead Hospital, Bristol

PL11 2TB

The Rame Group Practice, Cornwall

CB7 5JD

Staploe Medical Centre, Ely

G20 7BE

FutureMeds Glasgow, Glasgow

HU3 2JZ

Hull Royal Infirmary, Hull

LE5 4PW

NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre, Leicester

L9 7AL

Aintree University Hospital, Liverpool

NE6 1SG

FutureMeds Newcastle, Newcastle upon Tyne

TR183DX

Atlantic Medical Group, Penzance

S65 1DA

Clifton Medical Centre, Rotherham

CW11 1EQ

Ashfields Primary Care Centre, Sandbach

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY