Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

PHASE3RecruitingINTERVENTIONAL
Enrollment

675

Participants

Timeline

Start Date

December 9, 2024

Primary Completion Date

January 2, 2029

Study Completion Date

July 30, 2029

Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG

Xaluritamig

Short-term IV infusion

DRUG

Abiraterone

Oral tablets

DRUG

Enzalutamide

Oral tablets

DRUG

Cabazitaxel

IV infusion

Trial Locations (147)

1011

RECRUITING

Centre Hospitalier Universitaire Vaudois, Lausanne

1020

RECRUITING

Krankenhaus der Barmherzigen Brueder Wien, Vienna

1090

RECRUITING

Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna

1200

RECRUITING

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels

2050

RECRUITING

Chris OBrien Lifehouse, Camperdown

2109

RECRUITING

Macquarie University, North Ryde

3004

RECRUITING

The Alfred Hospital, Melbourne

3010

RECRUITING

Inselspital Bern, Bern

3100

RECRUITING

Universitaetsklinikum Sankt Poelten, Sankt Pölten

3168

RECRUITING

Monash Medical Centre, Clayton

4000

RECRUITING

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège

4020

RECRUITING

Ordensklinikum Linz Elisabethinen, Linz

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

5020

RECRUITING

Landeskrankenhaus Salzburg, Salzburg

6020

RECRUITING

Medizinische Universitaet Innsbruck, Innsbruck

6150

RECRUITING

Fiona Stanley Hospital, Murdoch

6500

RECRUITING

Istituto Oncologico della Svizzera Italiana, Bellinzona

7000

RECRUITING

Kantonsspital Graubuenden, Chur

7100

RECRUITING

Vejle Sygehus, Vejle

8036

RECRUITING

Medizinische Universitaet Graz, Graz

8200

RECRUITING

Aarhus University Hospital, Aarhus N

8500

RECRUITING

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk

9000

RECRUITING

Universitair Ziekenhuis Gent, Ghent

9007

RECRUITING

Kantonsspital Sankt Gallen, Sankt Gallen

10002

RECRUITING

National Taiwan University Hospital, Taipei

10043

RECRUITING

Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10117

RECRUITING

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin

10408

RECRUITING

National Cancer Center, Goyang-si, Gyeonggi-do

10467

RECRUITING

Montefiore Medical Center, The Bronx

11528

RECRUITING

Alexandra Hospital, Athens

13009

RECRUITING

Institut Paoli Calmettes, Marseille

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

15125

RECRUITING

Athens Medical Center S.A - Iatriko Amarousiou, Athens

15232

RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

15562

RECRUITING

Metropolitan General, Athens

16132

RECRUITING

Ospedale Policlinico San Martino IRCCS, Genova

18547

RECRUITING

Metropolitan Hospital, Athens

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20132

RECRUITING

IRCCS Ospedale San Raffaele, Milan

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20246

RECRUITING

Universitaetsklinikum Hamburg Eppendorf, Hamburg

23502

RECRUITING

Virginia Oncology Associates, Norfolk

23538

RECRUITING

Universitaetsklinikum Schleswig-Holstein - Luebeck, Lübeck

27710

RECRUITING

Duke University, Durham

28040

RECRUITING

Hospital Clinico San Carlos, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28204

RECRUITING

Levine Cancer Institute, Charlotte

29011

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

31059

RECRUITING

Institut Universitaire du Cancer Toulouse Oncopole, Toulouse

32610

RECRUITING

University of Florida, College of Medicine, Gainesville

32804

RECRUITING

AdventHealth Orlando, Orlando

33075

RECRUITING

Centre Hospitalier Universitaire de Bordeaux - Hopital Saint Andre, Bordeaux

33136

RECRUITING

Sylvester Comprehensive Cancer Center-Fox Building, Miami

33305

RECRUITING

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District

34214

RECRUITING

Bagcilar Medipol Mega Universite Hastanesi, Istanbul

35015

RECRUITING

Chungnam National University Hospital, Daejeon

35575

RECRUITING

Izmir Ekonomi Universitesi Medical Point Hastanesi, Izmir

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

RECRUITING

Tennessee Oncology PLLC, Nashville

38122

RECRUITING

Ospedale Santa Chiara Azienda Provinciale per i Servizi Sanitari Provincia Autonoma di Trento, Trento

38700

RECRUITING

Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon, La Tronche

40202

RECRUITING

University of Louisville Health - James Graham Brown Cancer Center, Louisville

40207

RECRUITING

Norton Cancer Institute, Louisville

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

43210

RECRUITING

The Ohio State University, Columbus

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45147

RECRUITING

Universitaetsklinikum Essen, Essen

46009

RECRUITING

Instituto Valenciano de Oncologia, Valencia

46202

RECRUITING

Indiana University, Indianapolis

48149

RECRUITING

Universitaetsklinikum Muenster, Münster

48202

RECRUITING

Henry Ford Hospital, Henry Ford Health Systems, Detroit

53705

RECRUITING

University of Wisconsin Carbone Cancer Center, Madison

55236

RECRUITING

Saint Luke Hospital, Thessaloniki

55455

RECRUITING

University of Minnesota, Minneapolis

57001

RECRUITING

European Interbalkan Medical Center, Thessaloniki

57104

RECRUITING

Sanford Oncology Clinic and Pharmacy, Sioux Falls

58122

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

60637

RECRUITING

University of Chicago, Chicago

63011

RECRUITING

Centre Jean Perrin, Clermont-Ferrand

63110

RECRUITING

Washington University, St Louis

69120

RECRUITING

Universitaetsklinikum Heidelberg, Heidelberg

70403

RECRUITING

National Cheng Kung University Hospital, Tainan City

71122

RECRUITING

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, Foggia

72000

RECRUITING

Clinique Victor Hugo - Centre Jean Bernard, Le Mans

73014

RECRUITING

Ospedale Sacro Cuore di Gesù Azienda Sanitaria Locale di Lecce, Gallipoli

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

80756

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

81675

RECRUITING

Klinikum rechts der Isar der TUM, München

91010

RECRUITING

City of Hope National Medical Center, Duarte

92697

RECRUITING

University of California Irvine, Irvine

92835

RECRUITING

Providence Saint Jude Medical Center, Fullerton

94163

RECRUITING

Hopital d Instruction des Armees - Hopital Begin, Saint-Mandé

94805

RECRUITING

Gustave Roussy, Villejuif

97078

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

98104

RECRUITING

Swedish Medical Center, Seattle

119074

RECRUITING

National University Hospital, Singapore

168583

RECRUITING

National Cancer Centre Singapore, Singapore

308433

RECRUITING

Tan Tock Seng Hospital, Singapore

02114

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana-Farber Cancer Institute, Boston

V5Z 4E6

RECRUITING

BC Cancer Vancouver, Vancouver

M5G 1Z5

RECRUITING

Princess Margaret Cancer Centre, Toronto

H3T 1E2

RECRUITING

Sir Mortimer B Davis - Jewish General Hospital, Montreal

G1R 2J6

RECRUITING

CHU de Quebec-Universite Laval, Québec

06189

RECRUITING

Centre Antoine Lacassagne, Nice

01307

RECRUITING

Universitaetsklinikum Dresden, Dresden

07747

RECRUITING

Universitaetsklinikum Jena, Jena

Unknown

RECRUITING

Queen Mary Hospital, The University of Hong Kong, Hong Kong

466-8560

RECRUITING

Nagoya University Hospital, Nagoya

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center, Matsuyama

371-8511

RECRUITING

Gunma University Hospital, Maebashi

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

920-8641

RECRUITING

Kanazawa University Hospital, Kanazawa

232-0024

RECRUITING

Yokohama City University Medical Center, Yokohama

541-8567

RECRUITING

Osaka International Cancer Institute, Osaka

565-0871

RECRUITING

The University of Osaka Hospital, Suita-shi

343-8555

RECRUITING

Dokkyo Medical University Saitama Medical Center, Koshigaya-shi

113-8603

RECRUITING

Nippon Medical School Hospital, Bunkyo-ku

135-8550

RECRUITING

The Cancer institute Hospital of Japanese Foundation for Cancer Research, Koto-ku

160-8582

RECRUITING

Keio University Hospital, Shinjuku-ku

2625 AD

RECRUITING

Reinier de Graaf Gasthuis, Delft

9713 GZ

RECRUITING

Universitair Medisch Centrum Groningen, Groningen

6525 GA

RECRUITING

Radboud Universitair Medisch Centrum, Nijmegen

3015 GD

RECRUITING

Erasmus Medisch Centrum, Rotterdam

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

31-501

RECRUITING

SPZOZ Szpital Uniwersytecki w Krakowie, Krakow

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

08035

RECRUITING

Hospital Universitari Vall d Hebron, Barcelona

08036

RECRUITING

Hospital Clinic i Provincial de Barcelona, Barcelona

08041

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08908

RECRUITING

Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, Barcelona

413 45

RECRUITING

Sahlgrenska Universitetssjukhuset, Gothenburg

221 85

RECRUITING

Skanes Universitetssjukhus, Lund

171 76

RECRUITING

Karolinska Universitetssjukhuset, Stockholm

901 85

RECRUITING

Norrlands Universitetssjukhus, Umeå

G12 0YN

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

NW1 2PG

RECRUITING

University College London Hospital, London

SE1 9RY

RECRUITING

Guys Hospital, London

W1G 6AD

RECRUITING

Sarah Cannon Research Institute UK, London

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY