Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

PHASE3RecruitingINTERVENTIONAL
Enrollment

12,800

Participants

Timeline

Start Date

July 25, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

September 29, 2030

Conditions
Atherosclerotic Cardiovascular DiseaseOverweightObesity
Interventions
DRUG

Maridebart Cafraglutide

Maridebart cafraglutide will be administered SC.

DRUG

Placebo

Placebo will be administered SC.

Trial Locations (162)

3170

RECRUITING

Advara HeartCare Mulgrave, Mulgrave

3220

RECRUITING

Barwon Health Geelong Hospital, Geelong

4064

RECRUITING

Core Research Group Pty Ltd, Milton

4066

RECRUITING

Advara HeartCare Wesley, Auchenflower

5068

RECRUITING

Advara HeartCare Leabrook, Leabrook

6027

RECRUITING

Advara HeartCare Joondalup, Joondalup

8091

RECRUITING

Universitaetsspital Zuerich, Zurich

12866

RECRUITING

Saratoga Clinical Research, LLC, Saratoga Springs

13905

RECRUITING

Velocity Clinical Research - Binghamton, Binghamton

14609

RECRUITING

Rochester Clinical Research, Rochester

15009

RECRUITING

Heritage Valley Multispecialty Group Inc, Beaver

17011

RECRUITING

Capital Area Research LLC, Camp Hill

19044

RECRUITING

Abington Medical Specialists, Horsham

19805

RECRUITING

Family Practice Associates, Wilmington

20745

RECRUITING

MD Medical Research, Oxon Hill

20854

RECRUITING

Velocity Clinical Research - Rockville, Rockville

21229

RECRUITING

Ascension Saint Agnes Heart Care, Baltimore

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

25827

RECRUITING

Vaught Neurological Services, Crab Orchard

26426

RECRUITING

Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon-do

27609

RECRUITING

Accellacare of Raleigh, Raleigh

27701

RECRUITING

Velocity Clinical Research - Durham, Durham

28112

RECRUITING

Monroe Biomedical Research, Monroe

28557

RECRUITING

West Clinical Research, Morehead City

28625

RECRUITING

Accellacare of Piedmont Healthcare, Statesville

28655

RECRUITING

Burke Primary Care Family Practice, Morganton

29464

RECRUITING

Accellacare Charleston, Mt. Pleasant

30114

RECRUITING

East Coast Institute for Research LLC at Canton Georgia, Canton

31210

RECRUITING

The Jones Center Clinical Research, Macon

31419

RECRUITING

Velocity Clinical Research - Savannah, Savannah

32086

RECRUITING

Saint Johns Center for Clinical Research, Saint Augustine

32127

RECRUITING

Progressive Medical Research, Port Orange

32132

RECRUITING

Velocity Clinical Research - New Smyrna Beach, Edgewater

32216

RECRUITING

East Coast Institute for Research, LLC, Jacksonville

33012

RECRUITING

Indago Research and Health Center, Hialeah

33013

RECRUITING

Elite Cardiac Research Center LLC, Hialeah

33014

RECRUITING

Panax Clinical Research, Miami Lakes

RECRUITING

San Marcus Research Clinic Inc, Miami Lakes

33021

RECRUITING

Zenith Clinical Research, Hollywood

33024

RECRUITING

Encore Medical Research LLC, Hollywood

33063

RECRUITING

South Florida Clinical Research, Margate

33126

RECRUITING

Finlay Medical Research, Miami

33135

RECRUITING

Suncoast Research Group LLC, Miami

33165

RECRUITING

New Horizon Research Center, Miami

33410

RECRUITING

Cardiology Partners Clinical Research Institute, Palm Beach Gardens

33434

RECRUITING

Excel Medical Clinical Trials, Boca Raton

33912

RECRUITING

Alliance for Multispecialty Research - Fort Myers, Fort Myers

33952

RECRUITING

Peace River Cardiovascular Center, Port Charlotte

34239

RECRUITING

Intercoastal Medical Group, Sarasota

34761

RECRUITING

West Orange Endocrinology, Ocoee

35660

RECRUITING

Syed Research Consultants LLC, Sheffield

35801

RECRUITING

Heart Center Research LLC, Huntsville

36526

RECRUITING

Alliance For Multispecialty Research - Daphne, Daphne

36532

RECRUITING

Eastern Shore Research Institute, Fairhope

36608

RECRUITING

Mobile Heart Specialists PC, Mobile

37388

RECRUITING

Tennessee Center for Clinical Trials, Tullahoma

37849

RECRUITING

Cardiovascular Research of Knoxville North Knoxville Medical Center, Powell

37912

RECRUITING

Accellacare of Knoxville, Knoxville

40213

RECRUITING

Louisville Metabolic and Atherosclerosis Research Center, Louisville

42601

RECRUITING

Keimyung University Dongsan Medical Center, Daegu

43201

RECRUITING

Endocrinology Associates Inc, Columbus

44033

RECRUITING

Ulsan University Hospital, Ulsan

44122

RECRUITING

Velocity Clinical Research - Cleveland, Beachwood

45219

RECRUITING

Velocity Clinical Research - Auburn, Cincinnati

45801

RECRUITING

Nexgen Research, Lima

46321

RECRUITING

Cardiovascular Research of Northwest Indiana LLC, Munster

46383

RECRUITING

Velocity Clinical Research - Valparaiso, Valparaiso

50010

RECRUITING

McFarland Clinic PC, Ames

52801

RECRUITING

Midwest Cardiovascular Research Foundation, Davenport

54401

RECRUITING

Aspirus Cardiovascular Associates, Wausau

55109

RECRUITING

Fairview Health Services M Health Fairview St Johns Hospital, Maplewood

57701

RECRUITING

Monument Health Clinical Research, Rapid City

60523

RECRUITING

Alliance For Multispecialty Research - Oak Brook, Oak Brook

60621

RECRUITING

Eagle Clinical Research, Chicago

62701

RECRUITING

Prarie Education and Research, Springfield

63136

RECRUITING

Saint Louis Heart and Vascular PC, St Louis

63303

RECRUITING

StudyMetrix Research, City of Saint Peters

64114

RECRUITING

Alliance for Multispecialty Research - Kansas City, Kansas City

66606

RECRUITING

Cotton-ONeil Diabetes and Endocrinology Center, Topeka

68046

RECRUITING

Primary Clinical Research, Papillion

68198

RECRUITING

University of Nebraska Medical Center, Omaha

68506

RECRUITING

Bryan Heart, Lincoln

70072

RECRUITING

Tandem Clinical Research - Marrero, Marrero

70433

RECRUITING

Cardiovascular Associates Research, LLC, Covington

73069

RECRUITING

Alliance for Multispecialty Research - Norman, Norman

75057

RECRUITING

Epic Clinical Research, Lewisville

75149

RECRUITING

Southern Endocrinology Associates PA, Mesquite

75208

RECRUITING

Thyroid Endocrinology and Diabetes, Dallas

75230

RECRUITING

Zenos Clinical Research, Dallas

76180

RECRUITING

North Hills Medical Research, North Richland Hills

76301

RECRUITING

Wichita Falls Heart Clinic, Wichita Falls

77043

RECRUITING

Biopharma Informatic, LLC, Houston

77070

RECRUITING

Cardiovascular Specialists of Willowbrook, Houston

77079

RECRUITING

PlanIt Research, PLLC, Houston

77089

RECRUITING

Research Physicians Network, LLC, Houston

77338

RECRUITING

Vital Heart and Vein, Humble

77339

RECRUITING

Tcr Institute Llc, Kingwood

77479

RECRUITING

Sugar Lakes Family Practice, Sugar Land

77566

RECRUITING

Helium Research Group, Lake Jackson

78231

RECRUITING

Consano Clinical Research - Shavano Park, Shavano Park

78249

RECRUITING

Bandera Family Health Care, San Antonio

78503

RECRUITING

Biopharma Informatic-McAllen, McAllen

78759

RECRUITING

Velocity Clinical Research - Austin, Austin

79106

RECRUITING

PharmaTex Research, LLC, Amarillo

79905

RECRUITING

David Turbay, MD, El Paso

79935

RECRUITING

Academy of Diabetes Thyroid and Endocrine, El Paso

83642

RECRUITING

Velocity Clinical Research - Boise, Meridian

84088

RECRUITING

Velocity Clinical Research - Salt Lake City, West Jordan

84604

RECRUITING

Boeson Research, Provo

85020

RECRUITING

Synexus Clinical Research US, Inc., Phoenix

85044

RECRUITING

Medical Advancement Centers of Arizona, Phoenix

89109

RECRUITING

Excel Clinical Research, Las Vegas

89128

RECRUITING

Vector Clinical Trials, Las Vegas

90255

RECRUITING

Velocity Clinical Research- Huntington Park, Huntington Park

91307

RECRUITING

Focus Clinical Research, West Hills

91726

RECRUITING

Valley Clinical Trials, LLC dba Flourish Research, Covina

91942

RECRUITING

Velocity Clinical Research- Los Angeles, La Mesa

91978

RECRUITING

Encompass Clinical Research, Spring Valley

92120

RECRUITING

Acclaim Clinical Research, San Diego

92630

RECRUITING

Orange County Research Center, Lake Forest

94598

RECRUITING

Diablo Clinical Research, Walnut Creek

96001

RECRUITING

Biopharma Informatic - The Cardiovascular Center, Redding

99218

RECRUITING

Velocity Clinical Research - Spokane, Spokane

119074

RECRUITING

National University Hospital, Singapore

169609

RECRUITING

National Heart Centre Singapore, Singapore

308433

RECRUITING

Tan Tock Seng Hospital, Singapore

529889

RECRUITING

Changi General Hospital, Singapore

544886

RECRUITING

Sengkang General Hospital, Singapore

690606

RECRUITING

Ng Teng Fong General Hospital, Singapore

02740

RECRUITING

Btc of New Bedford, New Bedford

02818

RECRUITING

Velocity Clinical Research - Providence, East Greenwich

V8T 5G4

RECRUITING

Discovery Clinical Services Ltd, Victoria

E1G 1A7

RECRUITING

G A Research Associates Limited, Moncton

L6S 0C6

RECRUITING

Centricity Research Brampton, Brampton

L6T 0G1

RECRUITING

Aggarwal and Associates Ltd, Brampton

M6B 3H7

RECRUITING

North York Diagnostic and Cardiac Centre, North York

M1B 4Z8

RECRUITING

Heart Health Institute Research Incorporated, Scarborough Village

L8J 3W2

RECRUITING

KMH Cardiology Centres Incorporated Hamilton, Stoney Creek

M6G 1M2

RECRUITING

Diabetes Heart Research Centre, Toronto

G7H 7K9

RECRUITING

Ecogene-21, Chicoutimi

H1T 1C8

RECRUITING

Montreal Heart Institute, Montreal

G1V 4G5

RECRUITING

Institut Universitaire de cardiologie et de pneumologie de Quebec, Québec

Unknown

RECRUITING

Queen Mary Hospital, The University of Hong Kong, Hong Kong

063-0826

RECRUITING

Miyanosawa Clinic of Internal Medicine and Cardiology, Sapporo

300-0028

RECRUITING

Tsuchiura Kyodo General Hospital, Tsuchiura-shi

920-8650

RECRUITING

National Hospital Organization Kanazawa Medical Center, Kanazawa

760-0017

RECRUITING

Takamatsu Red Cross Hospital, Takamatsu

892-0822

RECRUITING

Tenyoukai Central Clinic, Kagoshima

870-0033

RECRUITING

Oita Red Cross Hospital, Ōita

565-0862

RECRUITING

Saiseikai Senri Hospital, Suita-shi

434-8533

RECRUITING

Japanese Red Cross Hamamatsu Hospital, Hamamatsu

192-0918

RECRUITING

Medical Corporation Kenshinkai Minamino Cardiovascular Hospital, Hachioji-shi

108-0073

RECRUITING

Tokyo Saiseikai Central Hospital, Minato-ku

168-0065

RECRUITING

NewHeart Watanabe Institute, Suginami-ku

683-8605

RECRUITING

Sanin Rosai Hospital, Yonago-shi

745-8522

RECRUITING

Tokuyama Central Hospital, Shunan-shi

00717

RECRUITING

Research and Cardiovascular, Ponce

02841

RECRUITING

Korea University Anam Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

05278

RECRUITING

Kyung Hee University Hospital at Gangdong, Seoul

FY4 3AD

RECRUITING

Waterloo Medical Centre, Blackpool

NE1 4LP

RECRUITING

Newcastle NIHR Commercial Research Delivery Centre, Newcastle

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY