Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

PHASE1RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

May 16, 2025

Primary Completion Date

April 23, 2031

Study Completion Date

April 23, 2031

Conditions
Small Cell Lung Cancer
Interventions
DRUG

YL201

YL201 will be administered as an IV infusion.

DRUG

Tarlatamab

Tarlatamab will be administered as an IV infusion.

DRUG

Atezolizumab

Atezolizumab will be administered as an IV infusion.

DRUG

Durvalumab

Durvalumab will be administered as an IV infusion.

Trial Locations (15)

33612

RECRUITING

Moffitt Cancer Center, Tampa

54104

RECRUITING

Sanford Oncology Clinic and Pharmacy, Sioux Falls

58122

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

63110

RECRUITING

Siteman Cancer Center, St Louis

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

92618

RECRUITING

City of Hope Orange County Lennar Foundation Cancer Center, Irvine

98104

RECRUITING

Swedish Medical Center, Seattle

250117

RECRUITING

Shandong Cancer Hospital, Jinan

350011

RECRUITING

Fujian Cancer Hospital, Fuzhou

611135

RECRUITING

West China Hospital of Sichuan University, Chengdu

06510

RECRUITING

Yale New Haven Hospital, New Haven

02215

RECRUITING

Dana Farber Cancer Institute, Boston

G1J 1Z4

RECRUITING

CHU de Quebec Hopital de l Enfant Jesus, Québec

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

MediLink

UNKNOWN

lead

Amgen

INDUSTRY