AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

434

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

September 6, 2027

Study Completion Date

September 9, 2030

Conditions
KRAS Altered Advanced or Metastatic Solid Tumors
Interventions
DRUG

AMG 410

Administered as an oral tablet.

DRUG

Pembrolizumab

Administered as an intravenous (IV) infusion.

DRUG

Panitumumab

Administered as an IV infusion.

Trial Locations (4)

3050

RECRUITING

Peter MacCallum Cancer Centre, Parkville

22031

RECRUITING

Next Virginia, Fairfax

78229

RECRUITING

Next Oncology, San Antonio

91010

RECRUITING

City of Hope National Medical Center, Duarte

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY