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Clinical Trials for AstraZeneca
Explore 800 clinical trials worldwide
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Showing 451-500 of 800 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: AstraZeneca
Clinical Trials (800)
NCT05517265
Acalabrutinib in Patients With Chronic Lymphocytic Leukemia With Direct Oral Anticoagulation (CICERO)
N/A
Active, not recruiting
45 participants
Started: Oct 12, 2022 · Completed: Mar 31, 2026
1 condition
2 sponsors
1 location
NCT05306743
PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
NA
Recruiting
126 participants
Started: Sep 23, 2022 · Completed: Dec 31, 2026
1 condition
4 sponsors
3 locations
NCT05514132
A Study to Evaluate the Safety and Pharmacokinetics of Ceralasertib in Combination With Durvalumab in Chinese Patients With Advanced Solid Tumours
PHASE1
Active, not recruiting
14 participants
Started: Sep 23, 2022 · Completed: Oct 1, 2025
1 condition
1 sponsor
2 locations
NCT05450692
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
PHASE3
Active, not recruiting
594 participants
Started: Sep 15, 2022 · Completed: Oct 6, 2025
1 condition
2 sponsors
193 locations
NCT05437250
National Acalabrutinib Observational Study
N/A
Active, not recruiting
350 participants
Started: Sep 13, 2022 · Completed: Nov 15, 2026
1 condition
1 sponsor
61 locations
NCT05057494
A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
PHASE3
Active, not recruiting
607 participants
Started: Sep 12, 2022 · Completed: Apr 10, 2029
1 condition
1 sponsor
38 locations
NCT05489211
Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
PHASE2
Recruiting
582 participants
Started: Sep 6, 2022 · Completed: Aug 19, 2026
7 conditions
2 sponsors
95 locations
NCT05061134
A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition
PHASE2
Active, not recruiting
194 participants
Started: Aug 11, 2022 · Completed: Nov 2, 2026
1 condition
1 sponsor
66 locations
NCT05261399
Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
PHASE3
Recruiting
324 participants
Started: Aug 3, 2022 · Completed: Dec 17, 2026
2 conditions
1 sponsor
283 locations
NCT05047172
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
PHASE3
Recruiting
1,683 participants
Started: Aug 2, 2022 · Completed: May 31, 2028
2 conditions
6 sponsors
129 locations
NCT05457257
Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations
PHASE4
Active, not recruiting
43 participants
Started: Jul 29, 2022 · Completed: Sep 30, 2025
1 condition
4 sponsors
35 locations
NCT05315674
Markers of COPD Exacerbations
N/A
Recruiting
150 participants
Started: Jul 25, 2022 · Completed: Dec 31, 2025
2 conditions
2 sponsors
1 location
NCT05257551
Tempus Sculptor Study: Small Cell Lung Cancer (SCLC) Observational Study
N/A
Recruiting
50 participants
Started: Jul 13, 2022 · Completed: Mar 31, 2026
1 condition
2 sponsors
11 locations
NCT05246514
A Single Arm Phase 2 Study to Evaluate Efficacy and Safety of Trastuzumab Deruxtecan for Patients With HER2 Mutant NSCLC
PHASE2
Active, not recruiting
72 participants
Started: Jul 13, 2022 · Completed: Mar 16, 2026
1 condition
2 sponsors
28 locations
NCT05460273
A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02)
PHASE1/PHASE2
Active, not recruiting
119 participants
Started: Jul 11, 2022 · Completed: Dec 31, 2025
2 conditions
2 sponsors
21 locations
NCT05267613
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
PHASE3
Recruiting
50 participants
Started: Jul 1, 2022 · Completed: Sep 6, 2027
1 condition
9 sponsors
55 locations
NCT05417594
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
PHASE1/PHASE2
Recruiting
695 participants
Started: Jun 24, 2022 · Completed: Jun 1, 2027
1 condition
1 sponsor
33 locations
NCT05236114
GEMINI-NSCLC: NSCLC Biomarker Study
N/A
Recruiting
1,200 participants
Started: Jun 22, 2022 · Completed: Jun 30, 2029
1 condition
2 sponsors
57 locations
NCT05367440
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
PHASE1/PHASE2
Recruiting
175 participants
Started: Jun 2, 2022 · Completed: Apr 17, 2031
1 condition
2 sponsors
27 locations
NCT05454787
Ondexxya for Intravenous Injection 200mg Drug Use Result Investigation (All Case Investigation)
N/A
Recruiting
300 participants
Started: Jun 2, 2022 · Completed: Nov 30, 2025
2 conditions
1 sponsor
89 locations
NCT05456867
A Multi-center, Non-interventional, Prospective Study of Durvalumab in Unresectable Locally Advanced NSCLC in Routine Clinical Practice in Russia
N/A
Recruiting
250 participants
Started: May 31, 2022 · Completed: Nov 30, 2026
1 condition
1 sponsor
24 locations
NCT05388370
PASS of Paediatric Patients Initiating Selumetinib
N/A
Recruiting
125 participants
Started: May 23, 2022 · Completed: May 23, 2028
1 condition
1 sponsor
45 locations
NCT05293249
dMAbs for Prevention of COVID-19
PHASE1
Active, not recruiting
61 participants
Started: May 19, 2022 · Completed: Dec 31, 2025
1 condition
4 sponsors
1 location
NCT05374512
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
PHASE3
Active, not recruiting
644 participants
Started: May 16, 2022 · Completed: Dec 3, 2025
1 condition
2 sponsors
227 locations
NCT04918186
Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer
PHASE2
Recruiting
60 participants
Started: May 3, 2022 · Completed: Dec 31, 2026
1 condition
4 sponsors
7 locations
NCT05303532
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
PHASE3
Enrolling by invitation
61 participants
Started: Apr 19, 2022 · Completed: Dec 31, 2026
1 condition
1 sponsor
130 locations
NCT05197192
A Phase-3-trial of Acalabrutinib, Obinutuzumab & Venetoclax Compared to Obinutuzumab and Venetoclax in Previously Untreated Patients With High Risk CLL
PHASE3
Recruiting
202 participants
Started: Apr 19, 2022 · Completed: May 31, 2028
1 condition
2 sponsors
30 locations
NCT05061550
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
PHASE2
Recruiting
630 participants
Started: Apr 14, 2022 · Completed: May 9, 2030
1 condition
2 sponsors
98 locations
NCT04397003
Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer
PHASE2
Active, not recruiting
6 participants
Started: Mar 30, 2022 · Completed: Sep 30, 2029
1 condition
3 sponsors
1 location
NCT04985266
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer
PHASE2
Recruiting
1,100 participants
Started: Mar 30, 2022 · Completed: Sep 1, 2030
2 conditions
7 sponsors
49 locations
NCT05301842
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
PHASE3
Active, not recruiting
760 participants
Started: Mar 28, 2022 · Completed: Feb 26, 2027
1 condition
1 sponsor
171 locations
NCT04106115
DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
PHASE1/PHASE2
Recruiting
64 participants
Started: Mar 25, 2022 · Completed: May 31, 2029
1 condition
3 sponsors
5 locations
NCT05348577
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
PHASE3
Active, not recruiting
1,035 participants
Started: Mar 25, 2022 · Completed: Mar 4, 2026
1 condition
1 sponsor
217 locations
NCT04711824
Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases
PHASE1/PHASE2
Recruiting
41 participants
Started: Mar 9, 2022 · Completed: Nov 30, 2026
2 conditions
3 sponsors
7 locations
NCT05182905
AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients
EARLY_PHASE1
Recruiting
97 participants
Started: Mar 9, 2022 · Completed: Sep 30, 2027
4 conditions
4 sponsors
1 location
NCT05215340
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
PHASE3
Recruiting
740 participants
Started: Mar 4, 2022 · Completed: Apr 30, 2028
1 condition
3 sponsors
242 locations
NCT05092412
Low-dose Radiotherapy Combined With Durvalumab, Chemotherapy(EP) in the Treatment of ES-SCLC
PHASE2
Active, not recruiting
30 participants
Started: Mar 2, 2022 · Completed: Jun 30, 2025
3 conditions
2 sponsors
3 locations
NCT03733535
Evaluating the Effect of Benralizumab in Severe, Poorly-controlled Eosinophilic Asthma Using Inhaled Hyperpolarized 129-Xenon MRI
NA
Active, not recruiting
29 participants
Started: Mar 1, 2022 · Completed: Dec 31, 2026
1 condition
2 sponsors
1 location
NCT05120349
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
PHASE3
Active, not recruiting
390 participants
Started: Feb 21, 2022 · Completed: Nov 1, 2032
1 condition
1 sponsor
139 locations
NCT05211895
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
PHASE3
Recruiting
860 participants
Started: Feb 18, 2022 · Completed: Sep 12, 2030
1 condition
2 sponsors
260 locations
NCT05138133
Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis
PHASE3
Recruiting
360 participants
Started: Feb 15, 2022 · Completed: Jul 7, 2028
1 condition
1 sponsor
233 locations
NCT05311488
Early Detection of Neuropathy in ATTRv
N/A
Active, not recruiting
47 participants
Started: Feb 14, 2022 · Completed: Feb 14, 2029
1 condition
3 sponsors
1 location
NCT05221840
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
PHASE3
Active, not recruiting
1,027 participants
Started: Feb 7, 2022 · Completed: Jul 2, 2030
1 condition
1 sponsor
202 locations
NCT05158387
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.
PHASE3
Active, not recruiting
1,172 participants
Started: Feb 7, 2022 · Completed: Mar 23, 2026
1 condition
1 sponsor
212 locations
NCT04430452
Hypofractionated Radiotherapy Followed by Durvalumab With or Without Tremelimumab for Liver Cancer After Progression on PD-1 Inhibition
PHASE2
Recruiting
21 participants
Started: Feb 4, 2022 · Completed: Feb 28, 2027
7 conditions
2 sponsors
1 location
NCT05251259
Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma
PHASE2
Active, not recruiting
622 participants
Started: Jan 27, 2022 · Completed: Jan 29, 2026
1 condition
1 sponsor
267 locations
NCT05309668
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
PHASE1/PHASE2
Active, not recruiting
36 participants
Started: Jan 21, 2022 · Completed: Apr 28, 2028
1 condition
2 sponsors
16 locations
NCT05089916
Radiation During Osimertinib Treatment: a Safety and Efficacy Cohort Study
PHASE2
Active, not recruiting
40 participants
Started: Jan 20, 2022 · Completed: Dec 31, 2026
3 conditions
2 sponsors
1 location
NCT05166889
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
PHASE3
Active, not recruiting
1,132 participants
Started: Jan 3, 2022 · Completed: Mar 23, 2026
1 condition
1 sponsor
212 locations
NCT04912687
Implementing Circulating Tumor DNA Analysis at Initial Diagnosis to Improve Management of Advanced NSCLC Patients
NA
Recruiting
580 participants
Started: Jan 1, 2022 · Completed: Aug 1, 2027
2 conditions
2 sponsors
9 locations
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