Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

PHASE3RecruitingINTERVENTIONAL
Enrollment

324

Participants

Timeline

Start Date

August 3, 2022

Primary Completion Date

June 26, 2025

Study Completion Date

December 17, 2026

Conditions
CarcinomaNon-Small-Cell Lung
Interventions
DRUG

Savolitinib

300 mg savolitinib (3 × 100 mg tablets twice daily) Administrative route : oral

DRUG

Osimertinib

"80 mg osimertinib~(1 × 80 mg tablet once daily) Administrative route : oral"

DRUG

Pemetrexed

Pemetrexed (500 mg/m2) Administrative route : IV infusion

DRUG

Cisplatin

Cisplatin (75 mg/m2) or Administrative route : IV infusion

DRUG

Carboplatin

Carboplatin (AUC5) Administrative route : IV infusion

Trial Locations (283)

100

RECRUITING

Research Site, Taipei

300

RECRUITING

Research Site, Hsinchu

404

RECRUITING

Research Site, Taichung

736

RECRUITING

Research Site, Liuying

1000

RECRUITING

Research Site, Brussels

NOT_YET_RECRUITING

Research Site, Manila

1100

RECRUITING

Research Site, Quezon City

1104

RECRUITING

Research Site, Quezon City

1112

NOT_YET_RECRUITING

Research Site, Quezon City

1140

WITHDRAWN

Research Site, Vienna

1200

WITHDRAWN

Research Site, Brussels

1370

RECRUITING

Research Site, Adana

1407

WITHDRAWN

Research Site, Sofia

1502

RECRUITING

Research Site, San Juan City

2000

RECRUITING

Research Site, Rosario

2123

RECRUITING

Research Site, Rosario

2145

NOT_YET_RECRUITING

Research Site, Westmead

2170

RECRUITING

Research Site, Liverpool

2298

RECRUITING

Research Site, Waratah NSW

2600

RECRUITING

Research Site, Baguio City

3000

RECRUITING

Research Site, Vratsa

3010

WITHDRAWN

Research Site, Bern

3168

RECRUITING

Research Site, Clayton

3220

WITHDRAWN

Research Site, Geelong

3500

RECRUITING

Research Site, Hasselt

4000

RECRUITING

Research Site, San Miguel de Tucumán

4002

RECRUITING

Research Site, Plovdiv

4031

RECRUITING

Research Site, Basel

4215

RECRUITING

Research Site, Southport

5020

RECRUITING

Research Site, Salzburg

5800

RECRUITING

Research Site, Pleven

6000

RECRUITING

Research Site, Cebu

WITHDRAWN

Research Site, Cebu City

6006

RECRUITING

Research Site, Badajoz

6100

RECRUITING

Research Site, Bacolod

6124

RECRUITING

Research Site, Perugia

6160

RECRUITING

Research Site, Fremantle

6300

RECRUITING

Research Site, Haskovo

6591

RECRUITING

Research Site, Seoul

6800

RECRUITING

Research Site, Ankara

7000

RECRUITING

Research Site, Mons

8000

RECRUITING

Research Site, Davao City

8035

RECRUITING

Research Site, Barcelona

8036

WITHDRAWN

Research Site, Graz

8063

RECRUITING

Research Site, Zurich

8401

WITHDRAWN

Research Site, Winterthur

8800

RECRUITING

Research Site, Roeselare

8916

RECRUITING

Research Site, Badalona

9000

RECRUITING

Research Site, Ghent

9010

WITHDRAWN

Research Site, Varna

9100

RECRUITING

Research Site, Sint-Niklaas

10000

RECRUITING

Research Site, Hanoi

10032

RECRUITING

Research Site, New York

10043

RECRUITING

Research Site, Orbassano

10210

RECRUITING

Research Site, Bangkok

10300

RECRUITING

Research Site, Dusit

10408

RECRUITING

Research Site, Goyang-si

10700

RECRUITING

Research Site, Bangkok

10990

RECRUITING

Research Site, Pulau Pinang

11259

RECRUITING

Research Site, Taipei

11527

RECRUITING

Research Site, Athens

13353

RECRUITING

Research Site, Berlin

13620

RECRUITING

Research Site, Gyeonggi-do

13915

RECRUITING

Research Site, Marseille

14004

RECRUITING

Research Site, Córdoba

14165

RECRUITING

Research Site, Berlin

15006

RECRUITING

Research Site, A Coruña

15586

RECRUITING

Research Site, Kota Bharu

16247

RECRUITING

Research Site, Suwon

17007

RECRUITING

Research Site, Girona

18341

RECRUITING

Research Site, Afula

20133

RECRUITING

Research Site, Milan

20141

RECRUITING

Research Site, Milan

21079

RECRUITING

Research Site, Dijon

21431

NOT_YET_RECRUITING

Research Site, Incheon

22000

RECRUITING

Research Site, Chanthaburi

22030

RECRUITING

Research Site, Edirne

28040

RECRUITING

Research Site, Madrid

NOT_YET_RECRUITING

Research Site, Madrid

28041

RECRUITING

Research Site, Madrid

28222

RECRUITING

Research Site, Majadahonda

29010

RECRUITING

Research Site, Málaga

29200

RECRUITING

Research Site, Brest

31100

RECRUITING

Research Site, Treviso

32763

WITHDRAWN

Research Site, Orange City

32804

RECRUITING

Research Site, Orlando

33076

RECRUITING

Research Site, Bordeaux

33081

RECRUITING

Research Site, Aviano

34214

RECRUITING

Research Site, Istanbul

34298

WITHDRAWN

Research Site, Montpellier

34376

RECRUITING

Research Site, Immenhausen

34722

RECRUITING

Research Site, Istanbul

35033

RECRUITING

Research Site, Rennes

35100

RECRUITING

Research Site, Izmir

35128

RECRUITING

Research Site, Padua

36312

RECRUITING

Research Site, Pontevedra

37019

RECRUITING

Research Site, Peschiera del Garda

37232

RECRUITING

Research Site, Nashville

38100

RECRUITING

Research Site, Hadera

40002

RECRUITING

Research Site, Muang

40705

RECRUITING

Research Site, Taichung

41003

RECRUITING

Research Site, Changsha

41009

RECRUITING

Research Site, Seville

41110

RECRUITING

Research Site, Larissa

41124

RECRUITING

Research Site, Modena

43126

RECRUITING

Research Site, Parma

44033

WITHDRAWN

Research Site, Ulsan

44718

WITHDRAWN

Research Site, Canton

44800

RECRUITING

Research Site, Saint-Herblain

46026

RECRUITING

Research Site, Valencia

47014

RECRUITING

Research Site, Meldola

47500

RECRUITING

Research Site, Petaling Jaya

48149

RECRUITING

Research Site, Münster

48202

WITHDRAWN

Research Site, Detroit

49933

RECRUITING

Research Site, Angers

50009

RECRUITING

Research Site, Zaragoza

50200

RECRUITING

Research Site, Chiang Mai

54622

RECRUITING

Research Site, Thessaloniki

59100

RECRUITING

Research Site, Kuala Lumpur

60590

RECRUITING

Research Site, Frankfurt A. Main

60805

WITHDRAWN

Research Site, Evergreen Park

62247

RECRUITING

Research Site, Chiayi City

66424

WITHDRAWN

Research Site, Homburg

67091

RECRUITING

Research Site, Strasbourg

70000

RECRUITING

Research Site, Ho Chi Minh City

70300

RECRUITING

Research Site, Be’er Ya‘aqov

70376

WITHDRAWN

Research Site, Stuttgart

71030

RECRUITING

Research Site, Baoding

71110

RECRUITING

Research Site, Heraklion

74245

RECRUITING

Research Site, Löwenstein

75005

RECRUITING

Research Site, Paris

75018

RECRUITING

Research Site, Paris

76000

RECRUITING

Research Site, Rouen

80138

RECRUITING

Research Site, Napoli

81925

RECRUITING

Research Site, München

82131

RECRUITING

Research Site, Gauting

83100

RECRUITING

Research Site, Avellino

83301

NOT_YET_RECRUITING

Research Site, Kaohsiung City

86021

RECRUITING

Research Site, Poitiers

88239

RECRUITING

Research Site, Wangen

88996

RECRUITING

Research Site, Sabak Bernam

90110

RECRUITING

Research Site, Hat Yai

91031

RECRUITING

Research Site, Jerusalem

92093

WITHDRAWN

Research Site, La Jolla

92151

RECRUITING

Research Site, Suresnes

93000

RECRUITING

Research Site, Bobigny

94010

RECRUITING

Research Site, Créteil

95123

RECRUITING

Research Site, Catania

96819

RECRUITING

Research Site, Honolulu

100000

RECRUITING

Research Site, Hanoi

100036

RECRUITING

Research Site, Beijing

101149

RECRUITING

Research Site, Beijing

110001

RECRUITING

Research Site, Shenyang

119881

WITHDRAWN

Research Site, Moscow

130012

RECRUITING

Research Site, Changchun

150040

RECRUITING

Research Site, Harbin

169610

RECRUITING

Research Site, Singapore

197022

WITHDRAWN

Research Site, Saint Petersburg

200030

RECRUITING

Research Site, Shanghai

230031

RECRUITING

Research Site, Hefei

233060

RECRUITING

Research Site, Bengbu

250022

RECRUITING

Research Site, Jinan

266035

RECRUITING

Research Site, Qingdao

276000

RECRUITING

Research Site, Linyi

308433

RECRUITING

Research Site, Singapore

310022

RECRUITING

Research Site, Hangzhou

330006

RECRUITING

Research Site, Nanchang

350001

RECRUITING

Research Site, Fuzhou

350011

RECRUITING

Research Site, Fuzhou

400016

RECRUITING

Research Site, Chongqing

410011

RECRUITING

Research Site, Changsha

410013

WITHDRAWN

Research Site, Changsha

430022

RECRUITING

Research Site, Hankou,Wuhan

430079

RECRUITING

Research Site, Wuhan

441021

RECRUITING

Research Site, Xiangyang

443003

RECRUITING

Research Site, Yichang

450008

RECRUITING

Research Site, Zhengzhou

454087

WITHDRAWN

Research Site, Chelyabinsk

518020

RECRUITING

Research Site, Shenzhen

610041

RECRUITING

Research Site, Chengdu

634050

WITHDRAWN

Research Site, Tomsk

700000

RECRUITING

Research Site, Ho Chi Minh City

710061

RECRUITING

Research Site, Xi'an

710100

RECRUITING

Research Site, Xi'an

900000

RECRUITING

Research Site, Can Tho

999077

RECRUITING

Research Site, Hong Kong

4800827

WITHDRAWN

Research Site, Temuco

6423906

RECRUITING

Research Site, Tel Aviv

7500000

WITHDRAWN

Research Site, Santiago

7500713

RECRUITING

Research Site, Santiago

7747629

RECRUITING

Research Site, Ashdod

02114

RECRUITING

Research Site, Boston

02215

WITHDRAWN

Research Site, Boston

07932

WITHDRAWN

Research Site, Florham Park

08903

RECRUITING

Research Site, New Brunswick

B1884BBF

RECRUITING

Research Site, Berazategui

C1125ABD

RECRUITING

Research Site, Buenos Aires

C1019ABS

RECRUITING

Research Site, CABA

X5004APD

WITHDRAWN

Research Site, Córdoba

B1602DQD

RECRUITING

Research Site, Florida

F5300COE

RECRUITING

Research Site, La Rioja

R8500ACE

RECRUITING

Research Site, Viedma

B-2650

RECRUITING

Research Site, Edegem

30110-022

RECRUITING

Research Site, Belo Horizonte

70390-700

RECRUITING

Research Site, Brasília

29308-014

RECRUITING

Research Site, Cachoeiro de Itapemirim

80810-050

RECRUITING

Research Site, Curitiba

98700-000

RECRUITING

Research Site, Ijuí

35162-189

RECRUITING

Research Site, Ipatinga

90035-903

RECRUITING

Research Site, Porto Alegre

90050-170

RECRUITING

Research Site, Porto Alegre

90540-140

RECRUITING

Research Site, Porto Alegre

20231-050

RECRUITING

Research Site, Rio de Janeiro

22793-080

RECRUITING

Research Site, Rio de Janeiro

41253-190

RECRUITING

Research Site, Salvador

41950-610

RECRUITING

Research Site, Salvador

04014-002

RECRUITING

Research Site, São Paulo

04538-132

RECRUITING

Research Site, São Paulo

04556-100

RECRUITING

Research Site, São Paulo

29043-260

RECRUITING

Research Site, Vitória

T2N 4N2

WITHDRAWN

Research Site, Calgary

L5M 2N1

WITHDRAWN

Research Site, Mississauga

M4N 3M5

RECRUITING

Research Site, Toronto

M5G 2M9

RECRUITING

Research Site, Toronto

H3T 1E2

RECRUITING

Research Site, Montreal

H3T 1M5

RECRUITING

Research Site, Montreal

02321

RECRUITING

Research Site, Saint-Quentin

09113

RECRUITING

Research Site, Chemnitz

115 27

RECRUITING

Research Site, Athens

124 62

RECRUITING

Research Site, Chaïdári

265 04

RECRUITING

Research Site, Rio

546 39

RECRUITING

Research Site, Thessaloniki

Unknown

RECRUITING

Research Site, Kowloon

RECRUITING

Research Site, Taipei

09042

RECRUITING

Research Site, Monserrato

00144

RECRUITING

Research Site, Roma

00152

RECRUITING

Research Site, Roma

113-8603

RECRUITING

Research Site, Bunkyō City

104-0045

RECRUITING

Research Site, Chūōku

812-8582

RECRUITING

Research Site, Fukuoka

036-8563

RECRUITING

Research Site, Hirosaki-shi

730-8518

RECRUITING

Research Site, Hiroshima

740-8510

RECRUITING

Research Site, Iwakuni-shi

920-8641

RECRUITING

Research Site, Kanazawa

277-8577

RECRUITING

Research Site, Kashiwa

650-0017

RECRUITING

Research Site, Kobe

650-0046

RECRUITING

Research Site, Kobe

860-8556

RECRUITING

Research Site, Kumamoto

830-0011

RECRUITING

Research Site, Kurume-shi

791-0288

WITHDRAWN

Research Site, Matsuyama

852-8501

RECRUITING

Research Site, Nagasaki

700-8558

RECRUITING

Research Site, Okayama

534-0021

RECRUITING

Research Site, Osaka

589-8511

RECRUITING

Research Site, Osakasayama-shi

591-8555

RECRUITING

Research Site, Sakaishi

003-0804

RECRUITING

Research Site, Sapporo

060-8638

RECRUITING

Research Site, Sapporo

980-0873

RECRUITING

Research Site, Sendai

411-8777

RECRUITING

Research Site, Sunto-gun

320-0834

RECRUITING

Research Site, Utsunomiya

641-8510

RECRUITING

Research Site, Wakayama

241-8515

RECRUITING

Research Site, Yokohama

1066CX

WITHDRAWN

Research Site, Amsterdam

15-003

RECRUITING

Research Site, Bialystok

30-727

WITHDRAWN

Research Site, Krakow

93-338

RECRUITING

Research Site, Lodz

10-357

RECRUITING

Research Site, Olsztyn

660-702

RECRUITING

Research Site, Jinju

06273

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08308

NOT_YET_RECRUITING

Research Site, Seoul

138-736

RECRUITING

Research Site, Seoul

08036

RECRUITING

Research Site, Barcelona

08208

RECRUITING

Research Site, Sabadell

CH-5405

RECRUITING

Research Site, Baden

BS2 8HW

NOT_YET_RECRUITING

Research Site, Bristol

LE1 5WW

WITHDRAWN

Research Site, Leicester

L7 3EW

WITHDRAWN

Research Site, Liverpool

SE1 9RT

RECRUITING

Research Site, London

M20 4BX

RECRUITING

Research Site, Manchester

NP10 8FZ

WITHDRAWN

Research Site, Newport

RG2 9LH

WITHDRAWN

Research Site, Reading

WV10 0QP

RECRUITING

Research Site, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY